LANRAPLENIB
Lanraplenib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target tyrosine-protein kinase SYK.
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Commercial
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Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 1 | 2 | — | — | — | 2 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | 2 | — | — | — | 2 |
| Mantle-cell lymphoma | D020522 | — | — | 1 | 2 | — | — | — | 2 |
| Leukemia | D007938 | — | C95 | 2 | 2 | — | — | — | 2 |
| Hematologic neoplasms | D019337 | — | — | — | 1 | — | — | — | 1 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | — | 1 | — | — | — | 1 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | — | 1 | — | — | — | 1 |
| Recurrence | D012008 | — | — | 1 | 1 | — | — | — | 1 |
| Anemia | D000740 | HP_0001903 | D64.9 | 1 | 1 | — | — | — | 1 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
| Inflammation | D007249 | MP_0001845 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | LANRAPLENIB |
| INN | lanraplenib |
| Description | Lanraplenib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target tyrosine-protein kinase SYK. |
| Classification | Small molecule |
| Drug class | spleen tyrosine kinase (Syk) inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1cncc(-c2cn3ccnc3c(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)n1 |
Identifiers
| PDB | — |
| CAS-ID | 1800046-95-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3986824 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | A6U64OU57E (ChemIDplus, GSRS) |
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Safety
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