LANICEMINE
Lanicemine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
11 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | 2 | 3 | — | — | — | 5 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 1 | 4 | — | — | — | 5 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 1 | 3 | — | — | — | 4 |
| Treatment-resistant depressive disorder | D061218 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | — | — | — | — | 4 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | 1 | — | — | — | — | 1 |
| Traumatic stress disorders | D040921 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | LANICEMINE |
| INN | lanicemine |
| Description | Lanicemine (AZD6765) is a low-trapping NMDA receptor antagonist that was under development by AstraZeneca for the management of severe and treatment-resistant depression. Lanicemine differs from ketamine in that it is a low-trapping NMDA receptor antagonist, showing similar rapid-acting antidepressant effects to ketamine in clinical trials but with little or no psychotomimetic side effects. However, lanicemine did not meet study endpoints, and its development was terminated by AstraZeneca in 2013.
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| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N[C@@H](Cc1ccccn1)c1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 153322-05-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL467084 |
| ChEBI ID | — |
| PubChem CID | 9794203 |
| DrugBank | — |
| UNII ID | 9TMU325RK3 (ChemIDplus, GSRS) |
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Trends
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Safety
Black-box Warning
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Adverse Events
0 adverse events reported
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