Ketoprofen
Ketoprofen (ketoprofen) is a small molecule pharmaceutical. Ketoprofen was first approved as Orudis on 1986-01-09. It is used to treat dysmenorrhea, osteoarthritis, and rheumatoid arthritis in the USA. The pharmaceutical is active against prostaglandin G/H synthase 2 and prostaglandin G/H synthase 1. In addition, it is known to target sodium-coupled monocarboxylate transporter 1.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Trade Name
FDA
EMA
Ketoprofen (discontinued: Actron, Ketoprofen, Nexcede, Orudis, Oruvail)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ketoprofen
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| ketophene | unapproved drug other | 2016-07-21 |
| ketoprofen | ANDA | 2025-09-09 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| rheumatoid arthritis | EFO_0000685 | D001172 | M06.9 |
| osteoarthritis | EFO_0002506 | D010003 | M15-M19 |
| dysmenorrhea | — | D004412 | N94.6 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
— M01: Antiinflammatory and antirheumatic products
— M01A: Antiinflammatory and antirheumatic products, non-steroids
— M01AE: Propionic acid derivatives, antiinflammatory and antirheumatic products
— M01AE03: Ketoprofen
— M01AE53: Ketoprofen, combinations
— M02: Topical products for joint and muscular pain
— M02A: Topical products for joint and muscular pain
— M02AA: Antiinflammatory preparations, non-steroids for topical use
— M02AA10: Ketoprofen
HCPCS
No data
Clinical
Clinical Trials
365 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | 6 | 10 | 1 | 3 | 19 |
| Postoperative pain | D010149 | — | G89.18 | — | 1 | 5 | 4 | 9 | 19 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | 8 | 3 | 5 | 17 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 6 | 8 | 2 | — | 15 |
| Malaria | D008288 | EFO_0001068 | B54 | — | — | 1 | 1 | 9 | 11 |
| Low back pain | D017116 | — | M54.5 | — | — | 1 | 3 | 4 | 8 |
| Sprains and strains | D013180 | — | — | — | — | 6 | 2 | — | 8 |
| Back pain | D001416 | — | M54 | — | — | 1 | 1 | 4 | 6 |
| Ankle injuries | D016512 | — | S93.4 | — | — | 3 | 2 | 1 | 6 |
| Emergencies | D004630 | — | — | — | — | — | 2 | 3 | 5 |
Show 30 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Musculoskeletal pain | D059352 | — | — | 1 | — | 3 | — | 4 | 8 |
| Neoplasms | D009369 | — | C80 | — | 1 | 1 | — | 6 | 7 |
| Anesthesia | D000758 | — | — | — | 1 | 1 | — | 5 | 6 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | 1 | 1 | 4 | — | 1 | 6 |
| Shoulder pain | D020069 | — | M25.51 | — | — | 1 | — | 3 | 4 |
| Hiv | D006678 | — | O98.7 | — | 1 | 1 | — | 3 | 4 |
| Tendinopathy | D052256 | EFO_1001434 | M77.9 | — | 1 | 3 | — | — | 4 |
| Acute pain | D059787 | — | R52 | — | 1 | 2 | — | — | 3 |
| Headache | D006261 | — | R51 | 1 | 1 | 2 | — | — | 3 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | 1 | — | 2 | 3 |
Show 15 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lung neoplasms | D008175 | — | C34.90 | — | 2 | — | — | 1 | 3 |
| Myalgia | D063806 | — | M79.1 | 1 | 1 | — | — | — | 2 |
| Head and neck neoplasms | D006258 | — | — | — | 2 | — | — | — | 2 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | 1 | — | — | 1 | 2 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | 1 | — | — | — | 1 |
| Uterine cervical neoplasms | D002583 | — | — | — | 1 | — | — | — | 1 |
| Neurologic manifestations | D009461 | — | — | — | 1 | — | — | — | 1 |
| Neuroinflammatory diseases | D000090862 | — | — | — | 1 | — | — | — | 1 |
| Pneumothorax | D011030 | — | J93.11 | — | 1 | — | — | — | 1 |
| Pleurodesis | D018700 | — | — | — | 1 | — | — | — | 1 |
Show 1 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | 1 | — | — | — | 18 | 19 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 1 | — | — | — | 8 | 9 |
| Covid-19 | D000086382 | — | U07.1 | 1 | — | — | — | 8 | 9 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 1 | — | — | — | 6 | 7 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | 1 | — | — | — | 6 | 7 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | 2 | 4 |
| Somatoform disorders | D013001 | — | F45 | 1 | — | — | — | 2 | 3 |
| Premature birth | D047928 | EFO_0003917 | O60 | 1 | — | — | — | 1 | 2 |
| Primary ovarian insufficiency | D016649 | EFO_0004266 | E28.3 | 1 | — | — | — | 1 | 2 |
| Premature menopause | D008594 | — | E28.31 | 1 | — | — | — | 1 | 2 |
Show 3 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | — | — | — | 9 | 9 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 9 | 9 |
| Aphasia | D001037 | — | R47.01 | — | — | — | — | 7 | 7 |
| Treatment-resistant depressive disorder | D061218 | — | — | — | — | — | — | 6 | 6 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 5 | 5 |
| Occupational stress | D000073397 | — | — | — | — | — | — | 5 | 5 |
| Ischemic stroke | D000083242 | — | — | — | — | — | — | 5 | 5 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 4 | 4 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | — | — | — | — | 4 | 4 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | — | — | 4 | 4 |
Show 229 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Ketoprofen |
| INN | ketoprofen |
| Description | Ketoprofen is an oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2. It has a role as a non-steroidal anti-inflammatory drug, an antipyretic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an environmental contaminant, a xenobiotic and a drug allergen. It is a member of benzophenones and an oxo monocarboxylic acid. It is functionally related to a propionic acid. |
| Classification | Small molecule |
| Drug class | anti-inflammatory/analgesic agents (ibuprofen type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C(=O)O)c1cccc(C(=O)c2ccccc2)c1 |
Identifiers
| PDB | — |
| CAS-ID | 22071-15-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL571 |
| ChEBI ID | 6128 |
| PubChem CID | 3825 |
| DrugBank | DB01009 |
| UNII ID | 90Y4QC304K (ChemIDplus, GSRS) |
Target
Agency Approved
PTGS2
PTGS2
PTGS1
PTGS1
Organism
Homo sapiens
Gene name
PTGS2
Gene synonyms
COX2
NCBI Gene ID
Protein name
prostaglandin G/H synthase 2
Protein synonyms
COX-2, cyclooxygenase 2, cyclooxygenase 2b, Cyclooxygenase-2, PGH synthase 2, PGHS-2, PHS II, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Uniprot ID
Mouse ortholog
Ptgs2 (19225)
prostaglandin G/H synthase 2 (Q543K3)
Alternate
SLC5A8
SLC5A8
Organism
Homo sapiens
Gene name
SLC5A8
Gene synonyms
AIT, SMCT, SMCT1
NCBI Gene ID
Protein name
sodium-coupled monocarboxylate transporter 1
Protein synonyms
Apical iodide transporter, Electrogenic sodium monocarboxylate cotransporter, Sodium iodide-related cotransporter, solute carrier family 5 (iodide transporter), member 8, solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8, Solute carrier family 5 member 8
Uniprot ID
Mouse ortholog
Slc5a8 (216225)
sodium-coupled monocarboxylate transporter 1 (Q8VD01)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Ketoprofen
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 329,821 documents
View more details
Safety
Black-box Warning
Black-box warning for: Ketoprofen
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
8,566 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use