Ketoprofen
Ketoprofen (ketoprofen) is a small molecule pharmaceutical. Ketoprofen was first approved as Orudis on 1986-01-09. It is used to treat dysmenorrhea, osteoarthritis, and rheumatoid arthritis in the USA. The pharmaceutical is active against prostaglandin G/H synthase 2 and prostaglandin G/H synthase 1. In addition, it is known to target sodium-coupled monocarboxylate transporter 1.
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Commercial
Trade Name
FDA
EMA
Ketoprofen (discontinued: Actron, Ketoprofen, Nexcede, Orudis, Oruvail)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ketoprofen
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| ketophene | unapproved drug other | 2016-07-21 |
| ketoprofen | ANDA | 2024-07-30 |
| kiprofen | ANDA | 2023-12-04 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
— M01: Antiinflammatory and antirheumatic products
— M01A: Antiinflammatory and antirheumatic products, non-steroids
— M01AE: Propionic acid derivatives, antiinflammatory and antirheumatic products
— M01AE03: Ketoprofen
— M01AE53: Ketoprofen, combinations
— M02: Topical products for joint and muscular pain
— M02A: Topical products for joint and muscular pain
— M02AA: Antiinflammatory preparations, non-steroids for topical use
— M02AA10: Ketoprofen
HCPCS
No data
Clinical
Clinical Trials
338 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | 6 | 10 | 2 | 3 | 20 |
| Postoperative pain | D010149 | — | G89.18 | — | 1 | 3 | 4 | 9 | 17 |
| Pain | D010146 | EFO_0003843 | R52 | — | 2 | 7 | 2 | 5 | 16 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 6 | 8 | 2 | — | 15 |
| Low back pain | D017116 | HP_0003419 | M54.5 | — | — | 1 | 3 | 4 | 8 |
| Back pain | D001416 | HP_0003418 | M54 | — | — | 1 | 3 | 4 | 8 |
| Sprains and strains | D013180 | — | — | — | — | 6 | 2 | — | 8 |
| Emergencies | D004630 | — | — | — | — | 1 | 1 | 3 | 5 |
| Cesarean section | D002585 | — | — | — | — | — | 4 | 1 | 5 |
| Ankle injuries | D016512 | — | S93.4 | — | — | 3 | 2 | — | 5 |
Show 30 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malaria | D008288 | EFO_0001068 | B54 | — | — | 1 | — | 9 | 10 |
| Musculoskeletal pain | D059352 | — | — | 1 | — | 3 | — | 4 | 8 |
| Neoplasms | D009369 | — | C80 | — | 1 | 1 | — | 6 | 7 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | 1 | 1 | 4 | — | 2 | 7 |
| Anesthesia | D000758 | — | — | — | 1 | 1 | — | 4 | 5 |
| Shoulder pain | D020069 | HP_0030834 | M25.51 | — | — | 1 | — | 3 | 4 |
| Headache | D006261 | HP_0002315 | R51 | 1 | 1 | 2 | — | 1 | 4 |
| Hiv | D006678 | — | — | — | 1 | 1 | — | 3 | 4 |
| Tendinopathy | D052256 | EFO_1001434 | M77.9 | — | 1 | 3 | — | — | 4 |
| Acute pain | D059787 | — | R52 | — | 1 | 2 | — | — | 3 |
Show 16 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | 2 | — | — | 1 | 3 |
| Myalgia | D063806 | HP_0003326 | M79.1 | 1 | 1 | — | — | — | 2 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | 1 | — | — | 1 | 2 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | 1 | — | — | — | 1 |
| Head and neck neoplasms | D006258 | — | — | — | 1 | — | — | — | 1 |
| Uterine cervical neoplasms | D002583 | HP_0030159 | — | — | 1 | — | — | — | 1 |
| Sclerosis | D012598 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | 1 | — | — | — | 17 | 18 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 1 | — | — | — | 9 | 10 |
| Covid-19 | D000086382 | — | — | 1 | — | — | — | 9 | 10 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 1 | — | — | — | 6 | 7 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | 3 | 5 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | 1 | — | — | — | 4 | 5 |
| Somatoform disorders | D013001 | — | F45 | 1 | — | — | — | 2 | 3 |
| Premature birth | D047928 | EFO_0003917 | O60 | 1 | — | — | — | 1 | 2 |
| Primary ovarian insufficiency | D016649 | EFO_0004266 | E28.3 | 1 | — | — | — | 1 | 2 |
| Premature menopause | D008594 | HP_0008209 | E28.31 | 1 | — | — | — | 1 | 2 |
Show 2 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | — | — | — | 9 | 9 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 9 | 9 |
| Aphasia | D001037 | HP_0002381 | R47.01 | — | — | — | — | 7 | 7 |
| Treatment-resistant depressive disorder | D061218 | — | — | — | — | — | — | 6 | 6 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 5 | 5 |
| Ischemic stroke | D000083242 | — | — | — | — | — | — | 5 | 5 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 4 | 4 |
| Diarrhea | D003967 | HP_0002014 | R19.7 | — | — | — | — | 4 | 4 |
| Occupational stress | D000073397 | — | — | — | — | — | — | 4 | 4 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | — | 4 | 4 |
Show 214 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ketoprofen |
| INN | ketoprofen |
| Description | Ketoprofen is an oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2. It has a role as a non-steroidal anti-inflammatory drug, an antipyretic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an environmental contaminant, a xenobiotic and a drug allergen. It is a member of benzophenones and an oxo monocarboxylic acid. It is functionally related to a propionic acid. |
| Classification | Small molecule |
| Drug class | anti-inflammatory/analgesic agents (ibuprofen type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C(=O)O)c1cccc(C(=O)c2ccccc2)c1 |
Identifiers
| PDB | — |
| CAS-ID | 22071-15-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL571 |
| ChEBI ID | 6128 |
| PubChem CID | 3825 |
| DrugBank | DB01009 |
| UNII ID | 90Y4QC304K (ChemIDplus, GSRS) |
Target
Agency Approved
PTGS2
PTGS2
PTGS1
PTGS1
Organism
Homo sapiens
Gene name
PTGS2
Gene synonyms
COX2
NCBI Gene ID
Protein name
prostaglandin G/H synthase 2
Protein synonyms
COX-2, cyclooxygenase 2, cyclooxygenase 2b, Cyclooxygenase-2, PGH synthase 2, PGHS-2, PHS II, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Uniprot ID
Mouse ortholog
Ptgs2 (19225)
prostaglandin G/H synthase 2 (Q543K3)
Alternate
SLC5A8
SLC5A8
Organism
Homo sapiens
Gene name
SLC5A8
Gene synonyms
AIT, SMCT, SMCT1
NCBI Gene ID
Protein name
sodium-coupled monocarboxylate transporter 1
Protein synonyms
Apical iodide transporter, Electrogenic sodium monocarboxylate cotransporter, Sodium iodide-related cotransporter, solute carrier family 5 (iodide transporter), member 8, solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8, Solute carrier family 5 member 8
Uniprot ID
Mouse ortholog
Slc5a8 (216225)
sodium-coupled monocarboxylate transporter 1 (Q8VD01)
Variants
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Financial
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Estimated US medical usage
Ketoprofen
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 276,011 documents
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Safety
Black-box Warning
Black-box warning for: Ketoprofen, Kiprofen
Adverse Events
Top Adverse Reactions
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7,242 adverse events reported
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