Taltz(ixekizumab)
Taltz (ixekizumab) is an antibody pharmaceutical. Ixekizumab was first approved as Taltz on 2016-03-22. It is used to treat psoriasis in the USA. It has been approved in Europe to treat psoriasis. The pharmaceutical is active against interleukin-17A.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| skin and connective tissue diseases | D017437 |
Trade Name
FDA
EMA
Taltz
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| taltz | Biologic Licensing Application | 2024-08-20 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| psoriasis | EFO_0000676 | D011565 | L40 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
63 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Psoriasis | D011565 | EFO_0000676 | L40 | 2 | 2 | 16 | 8 | 6 | 33 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | 2 | 1 | 5 | 3 | 2 | 13 |
| Psoriatic arthritis | D015535 | EFO_0003778 | L40.5 | — | — | 6 | 3 | 2 | 11 |
| Spondylitis | D013166 | — | M46.9 | — | — | 7 | 1 | 1 | 9 |
| Spondylarthritis | D025241 | — | — | — | — | 6 | 1 | 1 | 8 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 2 | 1 | — | 1 | 1 | 5 |
| Uveitis | D014605 | HP_0000554 | H20.9 | — | — | — | 1 | — | 1 |
| Intermediate uveitis | D015867 | EFO_1000986 | — | — | — | — | 1 | — | 1 |
| Anterior uveitis | D014606 | EFO_1000811 | — | — | — | — | 1 | — | 1 |
| Posterior uveitis | D015866 | EFO_1001119 | — | — | — | — | 1 | — | 1 |
Show 2 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Axial spondyloarthritis | D000089183 | — | — | — | — | 5 | — | — | 5 |
| Ankylosing spondylitis | D013167 | EFO_0003898 | M45 | — | — | 2 | — | 1 | 3 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | 2 | — | — | 2 |
| Overweight | D050177 | — | E66.3 | — | — | 2 | — | — | 2 |
| Covid-19 | D000086382 | — | — | — | — | 1 | — | — | 1 |
| Juvenile arthritis | D001171 | EFO_1002007 | M08 | — | — | 1 | — | — | 1 |
| Enthesopathy | D000070676 | — | M77.9 | — | — | 1 | — | — | 1 |
| Non-radiographic axial spondyloarthritis | D000089202 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | 1 | — | — | — | 1 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 1 | — | — | — | 1 |
| Pityriasis rubra pilaris | D010916 | — | L44.0 | — | 1 | — | — | — | 1 |
| Exfoliative dermatitis | D003873 | — | L26 | — | 1 | — | — | — | 1 |
| Pityriasis | D010915 | — | — | — | 1 | — | — | — | 1 |
| Pyoderma gangrenosum | D017511 | EFO_0006835 | L88 | — | 1 | — | — | — | 1 |
| Pyoderma | D011711 | HP_0000999 | L08.0 | — | 1 | — | — | — | 1 |
| Bullous pemphigoid | D010391 | EFO_0007187 | L12 | — | 1 | — | — | — | 1 |
| Depression | D003863 | — | F33.9 | — | 1 | — | — | — | 1 |
| Treatment-resistant depressive disorder | D061218 | — | — | — | 1 | — | — | — | 1 |
Show 4 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | — | — | — | — | 4 |
| Lichen planus | D008010 | — | L43 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | — | — | — | 1 | 1 |
| Dermatitis | D003872 | HP_0011123 | L30.9 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ixekizumab |
| INN | ixekizumab |
| Description | Ixekizumab (humanized mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >6NOV:A,C|Fab Heavy Chain
QVQLVQSGAEVKKPGSSVKVSCKASGYSFTDYHIHWVRQAPGQGLEWMGVINPMYGTTDYNQRFKGRVTITADESTSTAY
MELSSLRSEDTAVYYCARYDYFTGTGVYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW
NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH
>6NOV:B,D|Fab Light Chain
DIVMTQTPLSLSVTPGQPASISCRSSRSLVHSRGNTYLHWYLQKPGQSPQLLIYKVSNRFIGVPDRFSGSGSGTDFTLKI
SRVEAEDVGVYYCSQSTHLPFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQ
SGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Identifiers
| PDB | 6NOU, 6NOV |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1743034 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB11569 |
| UNII ID | BTY153760O (ChemIDplus, GSRS) |
Target
Agency Approved
IL17A
IL17A
Organism
Homo sapiens
Gene name
IL17A
Gene synonyms
CTLA8, IL17
NCBI Gene ID
Protein name
interleukin-17A
Protein synonyms
CTLA-8, Cytotoxic T-lymphocyte-associated antigen 8, cytotoxic T-lymphocyte-associated protein 8, interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8), interleukin-17
Uniprot ID
Mouse ortholog
Il17a (16171)
interleukin-17A (Q62386)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
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£
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Taltz – Eli Lilly
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Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 4,055 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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28,108 adverse events reported
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