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Drug ReportsIvermectin
Ivermectin
Ivermectin, Sklice, Soolantra, Stromectol (ivermectin) is an unknown pharmaceutical. Ivermectin was first approved as Stromectol on 1996-11-22. It is used to treat ascariasis, elephantiasis, enterobiasis, lice infestations, and mansonelliasis amongst others in the USA. It is known to target P2X purinoceptor 4, neuronal acetylcholine receptor subunit alpha-7, and P2X purinoceptor 7.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
hemic and lymphatic diseasesD006425
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
Ivermectin, Sklice, Soolantra, Stromectol (discontinued: Ivermectin, Stromectol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ivermectin
Tradename
Company
Number
Date
Products
SKLICEArbor PharmaceuticalsN-202736 OTC2012-02-07
1 products, RLD, RS
SOOLANTRAGaldermaN-206255 RX2014-12-19
1 products, RLD, RS
STROMECTOLMerck & CoN-050742 RX1998-10-08
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
171083 ivermectin 1% / metronidazole 1% / niacinamide 4%unapproved drug other2020-07-02
2-oak mix, red/white pollen 3-oak mix, black/blackjack/post pollen 3-ragweed mix, giant/short/western pollen 4-pine mix, austrian/loblolly/scotch/w...Biologic Licensing Application2011-03-11
brimonidine tartrate 0.25% / ivermectin 1% / metronidazole 1% / niacinamide 4%unapproved drug other2019-05-15
ivermectinANDA2024-11-19
ivermectin 1% / metronidazole 1%unapproved drug other2019-04-24
ivermectin 1% / metronidazole 1% / niacinamide 4%unapproved drug other2020-06-04
skliceNew Drug Application2024-07-11
soolantraNew Drug Application2024-10-24
stromectolNew Drug Application2024-11-05
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
lice infestations—D010373B85.2
scabies—D012532B86
strongyloidiasisEFO_0007501D013322B78
onchocerciasisEFO_0007402D009855B73
mansonelliasisEFO_0007357D008368B74.4
trichuriasisEFO_0007524D014257—
ascariasisEFO_0007154D001196B77
enterobiasis—D017229B80
elephantiasisEFO_0004711D004604—
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Ivermectin, Soolantra, Galderma Labs Lp
90895872034-03-13U-1631
92331172034-03-13U-1631
92331182034-03-13U-1631
97824252034-03-13U-1631
102069392034-03-13U-1631
75504402024-04-22DPU-1631
80805302024-04-22DPU-1631
80932192024-04-22DPU-1631
84153112024-04-22DPU-1631
84707882024-04-22DPU-1631
88158162024-04-22DPU-1631
110335652024-04-22DP
ATC Codes
D: Dermatologicals
— D11: Other dermatological preparations in atc
— D11A: Other dermatological preparations in atc
— D11AX: Other dermatological preparations in atc
— D11AX22: Ivermectin
P: Antiparasitic products, insecticides and repellents
— P02: Anthelmintics
— P02C: Antinematodal agents
— P02CF: Avermectines
— P02CF01: Ivermectin
HCPCS
No data
Clinical
No data
Drug
General
Drug common nameIvermectin
INNivermectin
Description
Ivermectin is an antiparasitic drug. After its discovery in 1975, its first uses were in veterinary medicine to prevent and treat heartworm and acariasis. Approved for human use in 1987, it is used to treat infestations including head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis and lymphatic filariasis. It works through many mechanisms to kill the targeted parasites, and can be taken by mouth, or applied to the skin for external infestations. It belongs to the avermectin family of medications.
Classification
Small molecule
Drug classantiparasitics (ivermectin type)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(CC[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O
Identifiers
PDB—
CAS-ID70288-86-7
RxCUI6069
ChEMBL IDCHEMBL1200633
ChEBI ID—
PubChem CID9812710
DrugBankDB00602
UNII ID8883YP2R6D (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
P2RX4
P2RX4
CHRNA7
CHRNA7
P2RX7
P2RX7
Organism
Homo sapiens
Gene name
P2RX4
Gene synonyms
NCBI Gene ID
5025
Protein name
P2X purinoceptor 4
Protein synonyms
ATP receptor, ATP-gated cation channel protein, P2X receptor, subunit 4, Purinergic receptor, purinergic receptor P2X, ligand gated ion channel, 4, purinergic receptor P2X4, purinoceptor P2X4
Uniprot ID
Q9UBG9
Mouse ortholog
P2rx4 (18438)
P2X purinoceptor 4 (Q9JJX6)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Ivermectin
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
No data
Safety
Black-box Warning
Black-box warning for: 2-oak mix, red/white pollen 3-oak mix, black/blackjack/post pollen 3-ragweed mix, giant/short/western pollen 4-pine mix, austrian/loblolly/scotch/w...
Adverse Events
0 adverse events reported
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