Ivermectin
Ivermectin, Sklice, Soolantra, Stromectol (ivermectin) is an unknown pharmaceutical. Ivermectin was first approved as Stromectol on 1996-11-22. It is used to treat ascariasis, elephantiasis, enterobiasis, lice infestations, and mansonelliasis amongst others in the USA. It is known to target P2X purinoceptor 4, neuronal acetylcholine receptor subunit alpha-7, and P2X purinoceptor 7.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Ivermectin, Sklice, Soolantra, Stromectol (discontinued: Ivermectin, Stromectol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ivermectin
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SKLICE | Arbor Pharmaceuticals | N-202736 OTC | 2012-02-07 | 1 products, RLD, RS |
| SOOLANTRA | Galderma | N-206255 RX | 2014-12-19 | 1 products, RLD, RS |
| STROMECTOL | Merck & Co | N-050742 RX | 1998-10-08 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 171083 ivermectin 1% / metronidazole 1% / niacinamide 4% | unapproved drug other | 2020-07-02 |
| 2-oak mix, red/white pollen 3-oak mix, black/blackjack/post pollen 3-ragweed mix, giant/short/western pollen 4-pine mix, austrian/loblolly/scotch/w... | Biologic Licensing Application | 2011-03-11 |
| brimonidine tartrate 0.25% / ivermectin 1% / metronidazole 1% / niacinamide 4% | unapproved drug other | 2019-05-15 |
| ivermectin | ANDA | 2024-10-29 |
| ivermectin 1% / metronidazole 1% | unapproved drug other | 2019-04-24 |
| ivermectin 1% / metronidazole 1% / niacinamide 4% | unapproved drug other | 2020-06-04 |
| sklice | New Drug Application | 2024-07-11 |
| soolantra | New Drug Application | 2024-10-24 |
| stromectol | New Drug Application | 2023-12-10 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Ivermectin, Soolantra, Galderma Labs Lp | |||
| 9089587 | 2034-03-13 | U-1631 | |
| 9233117 | 2034-03-13 | U-1631 | |
| 9233118 | 2034-03-13 | U-1631 | |
| 9782425 | 2034-03-13 | U-1631 | |
| 10206939 | 2034-03-13 | U-1631 | |
| 7550440 | 2024-04-22 | DP | U-1631 |
| 8080530 | 2024-04-22 | DP | U-1631 |
| 8093219 | 2024-04-22 | DP | U-1631 |
| 8415311 | 2024-04-22 | DP | U-1631 |
| 8470788 | 2024-04-22 | DP | U-1631 |
| 8815816 | 2024-04-22 | DP | U-1631 |
| 11033565 | 2024-04-22 | DP | |
ATC Codes
D: Dermatologicals
— D11: Other dermatological preparations in atc
— D11A: Other dermatological preparations in atc
— D11AX: Other dermatological preparations in atc
— D11AX22: Ivermectin
P: Antiparasitic products, insecticides and repellents
— P02: Anthelmintics
— P02C: Antinematodal agents
— P02CF: Avermectines
— P02CF01: Ivermectin
HCPCS
No data
Clinical
Clinical Trials
233 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | — | 9 | 36 | 36 | 7 | 17 | 86 |
| Infections | D007239 | EFO_0000544 | — | 3 | 11 | 5 | 3 | 5 | 24 |
| Filarial elephantiasis | D004605 | EFO_0007272 | B74.0 | 1 | 4 | 5 | 4 | 9 | 22 |
| Filariasis | D005368 | — | B74 | 1 | 4 | 5 | 4 | 9 | 22 |
| Elephantiasis | D004604 | EFO_0004711 | — | 1 | 4 | 5 | 4 | 9 | 22 |
| Scabies | D012532 | — | B86 | 1 | 4 | 6 | 2 | 4 | 17 |
| Onchocerciasis | D009855 | EFO_0007402 | B73 | — | 5 | 5 | 2 | 5 | 17 |
| Rosacea | D012393 | — | L71 | 3 | 3 | 7 | 2 | 1 | 15 |
| Lice infestations | D010373 | — | B85.2 | 3 | 2 | 5 | 1 | 2 | 13 |
| Malaria | D008288 | EFO_0001068 | B54 | 2 | 3 | 7 | 1 | 1 | 12 |
Show 13 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Strongyloidiasis | D013322 | EFO_0007501 | B78 | — | 2 | 6 | — | 2 | 10 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | 2 | 5 | 1 | — | 1 | 8 |
| Severe acute respiratory syndrome | D045169 | EFO_0000694 | J12.81 | 3 | 4 | 1 | — | 1 | 7 |
| Parasitic diseases | D010272 | EFO_0001067 | B88 | 1 | — | 2 | — | 4 | 7 |
| Trichuriasis | D014257 | EFO_0007524 | — | — | 4 | 4 | — | 1 | 7 |
| Pediculus | D010374 | — | — | 1 | 1 | 5 | — | — | 7 |
| Ascariasis | D001196 | EFO_0007154 | B77 | — | 2 | 2 | — | 1 | 4 |
| Hookworm infections | D006725 | EFO_0007314 | B76 | — | 2 | 2 | — | 1 | 4 |
| Ancylostomiasis | D000724 | EFO_0007145 | B76.0 | — | 2 | 2 | — | 1 | 4 |
| Dengue | D003715 | — | A90 | — | 2 | 1 | — | — | 2 |
Show 13 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Severe acute respiratory syndrome-related coronavirus | D045473 | NCBITaxon_227859 | — | 2 | 2 | — | — | — | 3 |
| Neoplasms | D009369 | — | C80 | — | 2 | — | — | — | 2 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | 1 | — | — | 1 | 2 |
| Poisoning | D011041 | EFO_0008546 | T65.91 | 1 | 1 | — | — | 1 | 2 |
| Ocular onchocerciasis | D015827 | EFO_0007398 | B73 | — | 2 | — | — | — | 2 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | 2 | — | — | — | 2 |
| Eczema | D004485 | HP_0000964 | L30.9 | — | 2 | — | — | — | 2 |
| Dermatitis | D003872 | HP_0011123 | L30.9 | — | 2 | — | — | — | 2 |
| Inflammation | D007249 | MP_0001845 | — | 1 | 1 | — | — | — | 1 |
| Wounds and injuries | D014947 | — | T14.8 | — | 1 | — | — | — | 1 |
Show 9 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Wuchereria bancrofti | D014958 | — | — | 1 | — | — | — | — | 1 |
| Combination drug therapy | D004359 | — | — | 1 | — | — | — | — | 1 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
| Therapeutic equivalency | D013810 | — | — | 1 | — | — | — | — | 1 |
| Visceral leishmaniasis | D007898 | — | B55.0 | 1 | — | — | — | — | 1 |
| Leishmaniasis | D007896 | EFO_0005044 | B55 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ventilator-associated pneumonia | D053717 | EFO_1001865 | J95.851 | — | — | — | — | 1 | 1 |
| Bacterial infections | D001424 | — | A49 | — | — | — | — | 1 | 1 |
| Respiratory insufficiency | D012131 | HP_0002093 | J96.9 | — | — | — | — | 1 | 1 |
| Hypoxia | D000860 | HP_0012418 | R09.02 | — | — | — | — | 1 | 1 |
| Urinalysis | D016482 | — | — | — | — | — | — | 1 | 1 |
| Neurotoxicity syndromes | D020258 | — | G92 | — | — | — | — | 1 | 1 |
| Dna sequence analysis | D017422 | — | — | — | — | — | — | 1 | 1 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | — | — | 1 | 1 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | — | — | — | — | 1 | 1 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | — | — | — | 1 | 1 |
Show 25 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ivermectin |
| INN | ivermectin |
| Description | Ivermectin is an antiparasitic drug. After its discovery in 1975, its first uses were in veterinary medicine to prevent and treat heartworm and acariasis. Approved for human use in 1987, it is used to treat infestations including head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis and lymphatic filariasis. It works through many mechanisms to kill the targeted parasites, and can be taken by mouth, or applied to the skin for external infestations. It belongs to the avermectin family of medications.
|
| Classification | Small molecule |
| Drug class | antiparasitics (ivermectin type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(CC[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 70288-86-7 |
| RxCUI | 6069 |
| ChEMBL ID | CHEMBL1200633 |
| ChEBI ID | — |
| PubChem CID | 9812710 |
| DrugBank | DB00602 |
| UNII ID | 8883YP2R6D (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
P2RX4
P2RX4
CHRNA7
CHRNA7
P2RX7
P2RX7
Organism
Homo sapiens
Gene name
P2RX4
Gene synonyms
NCBI Gene ID
Protein name
P2X purinoceptor 4
Protein synonyms
ATP receptor, ATP-gated cation channel protein, P2X receptor, subunit 4, Purinergic receptor, purinergic receptor P2X, ligand gated ion channel, 4, purinergic receptor P2X4, purinoceptor P2X4
Uniprot ID
Mouse ortholog
P2rx4 (18438)
P2X purinoceptor 4 (Q9JJX6)
Variants
No data
Financial
Revenue by drug
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Estimated US medical usage
Ivermectin
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 18,415 documents
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Safety
Black-box Warning
Black-box warning for: 2-oak mix, red/white pollen 3-oak mix, black/blackjack/post pollen 3-ragweed mix, giant/short/western pollen 4-pine mix, austrian/loblolly/scotch/w...
Adverse Events
Top Adverse Reactions
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4,533 adverse events reported
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