Tradename | Company | Number | Date | Products |
---|---|---|---|---|
SKLICE | Arbor Pharmaceuticals | N-202736 OTC | 2012-02-07 | 1 products, RLD, RS |
SOOLANTRA | Galderma | N-206255 RX | 2014-12-19 | 1 products, RLD, RS |
STROMECTOL | Merck Sharp & Dohme | N-050742 RX | 1998-10-08 | 1 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
brimonidine tartrate 0.25% / ivermectin 1% / metronidazole 1% / niacinamide 4% | unapproved drug other | 2019-05-15 |
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Ivermectin, Soolantra, Galderma Labs Lp | |||
9089587 | 2034-03-13 | U-1631 | |
9233117 | 2034-03-13 | U-1631 | |
9233118 | 2034-03-13 | U-1631 | |
9782425 | 2034-03-13 | U-1631 | |
10206939 | 2034-03-13 | U-1631 | |
7550440 | 2024-04-22 | DP | U-1631 |
8080530 | 2024-04-22 | DP | U-1631 |
8093219 | 2024-04-22 | DP | U-1631 |
8415311 | 2024-04-22 | DP | U-1631 |
8470788 | 2024-04-22 | DP | U-1631 |
8815816 | 2024-04-22 | DP | U-1631 |
11033565 | 2024-04-22 | DP |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Covid-19 | D000086382 | — | U07.1 | 9 | 33 | 30 | 7 | 16 | 78 |
Filarial elephantiasis | D004605 | EFO_0007272 | B74.0 | — | 4 | 4 | 4 | 8 | 19 |
Scabies | D012532 | — | B86 | 1 | 3 | 6 | 2 | 4 | 16 |
Onchocerciasis | D009855 | EFO_0007402 | B73 | — | 5 | 5 | 1 | 5 | 16 |
Rosacea | D012393 | — | L71 | 2 | 3 | 6 | 2 | — | 12 |
Malaria | D008288 | EFO_0001068 | B54 | 2 | 3 | 6 | 1 | 1 | 11 |
Healthy volunteers/patients | — | — | — | 7 | 1 | — | 1 | — | 8 |
Pneumonia | D011014 | EFO_0003106 | — | — | 2 | 3 | 1 | 1 | 5 |
Epilepsy | D004827 | EFO_0000474 | G40.9 | — | — | — | 2 | 2 | 4 |
Trachoma | D014141 | — | A71 | — | — | 1 | 2 | — | 3 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Coronavirus infections | D018352 | EFO_0007224 | B34.2 | 2 | 5 | 1 | — | 1 | 8 |
Trichuriasis | D014257 | EFO_0007524 | B79 | — | 4 | 4 | — | 1 | 7 |
Pediculus | D010374 | — | — | 1 | 1 | 5 | — | — | 7 |
Strongyloidiasis | D013322 | EFO_0007501 | B78 | — | — | 5 | — | 1 | 6 |
Infections | D007239 | EFO_0000544 | — | — | 3 | 4 | — | 1 | 6 |
Lice infestations | D010373 | — | B85.2 | 1 | — | 1 | — | 2 | 4 |
Ascariasis | D001196 | EFO_0007154 | B77 | — | 2 | 2 | — | 1 | 4 |
Hookworm infections | D006725 | EFO_0007314 | B76 | — | 2 | 2 | — | 1 | 4 |
Sarcoidosis | D012507 | EFO_0000690 | D80-D89 | — | 1 | 1 | — | — | 1 |
Dengue | D003715 | — | A90 | — | 1 | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Severe acute respiratory syndrome | D045169 | EFO_0000694 | J12.81 | 2 | 3 | — | — | 1 | 4 |
Helminthiasis | D006373 | EFO_1001342 | B65-B83 | 1 | 1 | — | — | 2 | 4 |
Severe acute respiratory syndrome-related coronavirus | D045473 | NCBITaxon_227859 | — | 2 | 2 | — | — | — | 3 |
Neoplasms | D009369 | — | C80 | — | 2 | — | — | — | 2 |
Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | 1 | — | — | 1 | 2 |
Poisoning | D011041 | EFO_0008546 | T65.91 | 1 | 1 | — | — | 1 | 2 |
Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | 2 | — | — | — | 2 |
Wounds and injuries | D014947 | — | T14.8 | — | 1 | — | — | — | 1 |
Ocular onchocerciasis | D015827 | EFO_0007398 | B73 | — | 1 | — | — | — | 1 |
Severe dengue | D019595 | — | A91 | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Parasitic diseases | D010272 | EFO_0001067 | B88 | — | — | — | — | 4 | 4 |
Bacterial infections | D001424 | — | A49 | — | — | — | — | 1 | 1 |
Respiratory insufficiency | D012131 | HP_0002093 | J96.9 | — | — | — | — | 1 | 1 |
Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
Dna sequence analysis | D017422 | — | — | — | — | — | — | 1 | 1 |
Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | — | — | 1 | 1 |
Tuberculosis | D014376 | EFO_0000774 | A15-A19 | — | — | — | — | 1 | 1 |
Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | — | — | — | 1 | 1 |
Smoking | D012907 | EFO_0004318 | — | — | — | — | — | 1 | 1 |
Radiation exposure | D000069079 | — | — | — | — | — | — | 1 | 1 |
Drug common name | Ivermectin |
INN | ivermectin |
Description | Ivermectin is an antiparasitic drug. After its discovery in 1975, its first uses were in veterinary medicine to prevent and treat heartworm and acariasis. Approved for human use in 1987, it is used to treat infestations including head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis and lymphatic filariasis. It works through many mechanisms to kill the targeted parasites, and can be taken by mouth, or applied to the skin for external infestations. It belongs to the avermectin family of medications.
|
Classification | Small molecule |
Drug class | antiparasitics (ivermectin type) |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(CC[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O |
PDB | — |
CAS-ID | 70288-86-7 |
RxCUI | 6069 |
ChEMBL ID | CHEMBL1200633 |
ChEBI ID | — |
PubChem CID | 9812710 |
DrugBank | DB00602 |
UNII ID | 8883YP2R6D (ChemIDplus, GSRS) |