Corlanor, Procoralan(ivabradine)
Corlanor, Corlentor, Ivabradine, Procoralan (ivabradine) is a small molecule pharmaceutical. Ivabradine was first approved as Procoralan on 2005-10-25. It is used to treat heart failure in the USA. It has been approved in Europe to treat angina pectoris and heart failure. It is known to target potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, and potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.
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Study first post date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Corlanor (generic drugs available since 2022-10-05)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| corlanor | New Drug Application | 2022-02-14 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| heart failure | EFO_0003144 | D006333 | I50 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
IVABRADINE, CORLANOR, AMGEN INC | |||
| 2026-10-22 | PED | ||
| 2026-04-22 | ODE-234 | ||
ATC Codes
C: Cardiovascular system drugs
— C01: Cardiac therapy drugs
— C01E: Other cardiac preparations in atc
— C01EB: Other plain cardiac preparations in atc
— C01EB17: Ivabradine
— C07: Beta-adrenergic blocking agents
— C07F: Beta blocking agents, other combinations
— C07FX: Beta blocking agents, other combinations
— C07FX05: Metoprolol and ivabradine
— C07FX06: Carvedilol and ivabradine
HCPCS
No data
Clinical
Clinical Trials
95 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | HP_0001635 | I50 | 1 | 4 | 5 | 12 | 10 | 30 |
| Coronary artery disease | D003324 | — | I25.1 | — | — | 1 | 5 | 2 | 8 |
| Postural orthostatic tachycardia syndrome | D054972 | — | G90.A | — | 3 | 1 | 1 | 1 | 6 |
| Systolic heart failure | D054143 | EFO_1001207 | I50.20 | — | 1 | 1 | 2 | 1 | 4 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | 2 | 1 | — | 3 |
| Dilated cardiomyopathy | D002311 | HP_0001644 | I42.0 | — | 1 | — | 1 | 1 | 3 |
| Cardiogenic shock | D012770 | — | R57.0 | — | — | 1 | 2 | — | 3 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | — | 1 | 1 | 2 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | 1 | 1 | — | 2 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | — | — | 1 | 1 | 2 |
Show 13 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | 1 | — | 2 | — | 3 | 6 |
| Neoplasms | D009369 | — | C80 | — | 1 | 1 | — | 1 | 3 |
| Left ventricular dysfunction | D018487 | — | — | — | — | 1 | — | 1 | 2 |
| Septic shock | D012772 | — | A48.3 | — | 1 | 1 | — | — | 2 |
| Angina pectoris | D000787 | EFO_0003913 | I20 | — | 1 | 1 | — | — | 2 |
| Non-st elevated myocardial infarction | D000072658 | — | — | — | 1 | 1 | — | — | 1 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | 1 | — | — | 1 |
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | — | 1 | — | — | 1 |
| Vascular stiffness | D059289 | — | — | — | — | 1 | — | — | 1 |
| Aging | D000375 | GO_0007568 | R41.81 | — | — | 1 | — | — | 1 |
Show 4 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diastolic heart failure | D054144 | EFO_1000899 | I50.30 | — | 1 | — | — | 1 | 2 |
| Hypotension | D007022 | EFO_0005251 | I95 | — | 1 | — | — | — | 1 |
| Lymphoma | D008223 | — | C85.9 | — | 1 | — | — | — | 1 |
| Multiple organ failure | D009102 | EFO_1001373 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | — | 1 | 1 |
| Portal hypertension | D006975 | EFO_0000666 | K76.6 | — | — | — | — | 1 | 1 |
| Computed tomography angiography | D000072226 | — | — | — | — | — | — | 1 | 1 |
| Cardiotoxicity | D066126 | EFO_1001482 | — | — | — | — | — | 1 | 1 |
| Bradycardia | D001919 | HP_0001662 | R00.1 | — | — | — | — | 1 | 1 |
| Sinus arrhythmia | D001146 | — | — | — | — | — | — | 1 | 1 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ivabradine |
| INN | ivabradine |
| Description | Ivabradine is a member of the class of benzazepines that is 7,8-dimethoxy-1,3,4,5-tetrahydro-3-benzazepin-2-one in which the amide hydrogen is replaced by a [{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl} group. Used (as its hydrochloride salt) to treat patients with angina who have intolerance to beta blockers and/or heart failure. It has a role as a cardiotonic drug. It is a benzazepine, a tertiary amino compound, a carbobicyclic compound and an aromatic ether. It is a conjugate base of an ivabradine(1+). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1cc2c(cc1OC)CC(=O)N(CCCN(C)C[C@H]1Cc3cc(OC)c(OC)cc31)CC2 |
Identifiers
| PDB | — |
| CAS-ID | 155974-00-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL471737 |
| ChEBI ID | 85966 |
| PubChem CID | 132999 |
| DrugBank | DB09083 |
| UNII ID | 3H48L0LPZQ (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
HCN1
HCN1
HCN2
HCN2
HCN4
HCN4
HCN3
HCN3
Organism
Homo sapiens
Gene name
HCN1
Gene synonyms
BCNG1
NCBI Gene ID
Protein name
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Protein synonyms
BCNG-1, Brain cyclic nucleotide-gated channel 1
Uniprot ID
Mouse ortholog
Hcn1 (15165)
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Q9D613)
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,602 adverse events reported
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