
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SPORANOX | Johnson & Johnson | N-020083 RX | 1992-09-11 | 1 products, RLD, RS |
| TOLSURA | Mayne Group | N-208901 RX | 2018-12-11 | 1 products, RLD, RS |
Brand Name | Status | Last Update |
|---|---|---|
| ciclopirox 3% / itraconazole 5% / urea 20% | unapproved drug other | 2019-05-20 |
| fluconazole 4% / ibuprofen 2% / itraconazole 1% / terbinafine hcl 4% | unapproved drug other | 2019-04-24 |
| itraconazole | ANDA | 2025-07-16 |
| itraconazole oral | ANDA | 2023-08-05 |
| sporanox | New Drug Application | 2024-12-30 |
| tolsura | New Drug Application | 2025-04-23 |
Code | Description |
|---|---|
| J1835 | Injection, itraconazole, 50 mg |

Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neutropenia | D009503 | — | D70 | — | 1 | — | 1 | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coccidioidomycosis | D003047 | EFO_0007211 | B38 | — | 1 | — | — | — | 1 |
| Coccidiosis | D003048 | EFO_0007212 | — | — | 1 | — | — | — | 1 |
| Drug common name | Itraconazole |
| INN | itraconazole |
| Description | Itraconazole is an N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis. It has a role as a P450 inhibitor, an EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor and a Hedgehog signaling pathway inhibitor. It is a member of triazoles, a dioxolane, a N-arylpiperazine, a dichlorobenzene, a cyclic ketal, a conazole antifungal drug, a triazole antifungal drug and an aromatic ether. |
| Classification | Small molecule |
| Drug class | systemic antifungals (miconazole type) |
| Image (chem structure or protein) | ![]() |
| Structure (InChI/SMILES or Protein Sequence) | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O |
| PDB | — |
| CAS-ID | 84625-61-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL64391 |
| ChEBI ID | — |
| PubChem CID | 55283 |
| DrugBank | DB01167 |
| UNII ID | 304NUG5GF4 (ChemIDplus, GSRS) |






