Itacitinib
Itacitinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against tyrosine-protein kinase JAK1. In addition, it is known to target tyrosine-protein kinase JAK2.
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54 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Graft vs host disease | D006086 | — | D89.81 | 6 | 5 | 2 | — | — | 11 |
| Bronchiolitis obliterans syndrome | D000092122 | — | D89.811 | 1 | 5 | 1 | — | — | 5 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 6 | 4 | — | — | — | 7 |
| Primary myelofibrosis | D055728 | — | D47.4 | — | 4 | — | — | — | 4 |
| B-cell lymphoma | D016393 | — | — | 3 | 3 | — | — | — | 4 |
| Syndrome | D013577 | — | — | 2 | 2 | — | — | — | 3 |
| Hematologic neoplasms | D019337 | — | — | 1 | 2 | — | — | — | 3 |
| Hodgkin disease | D006689 | — | C81 | 2 | 1 | — | — | — | 3 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 3 | — | — | — | 3 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 1 | 2 | — | — | — | 3 |
| Cytokine release syndrome | D000080424 | — | D89.83 | 1 | 1 | — | — | — | 2 |
| Polycythemia vera | D011087 | — | D45 | — | 2 | — | — | — | 2 |
Show 15 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Melanoma | D008545 | — | — | 2 | — | — | — | — | 2 |
| Leukemia | D007938 | — | C95 | 2 | — | — | — | — | 2 |
| Myelodysplastic syndromes | D009190 | — | D46 | 2 | — | — | — | — | 2 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | — | — | — | — | 1 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 1 | — | — | — | — | 1 |
| Mantle-cell lymphoma | D020522 | — | C83.1 | 1 | — | — | — | — | 1 |
| Refractory anemia with excess of blasts | D000754 | — | D46.2 | 1 | — | — | — | — | 1 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | — | — | — | — | 1 |
| Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | — | 1 |
Show 17 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anemia | D000740 | EFO_0004272 | D64.9 | — | — | — | — | 1 | 1 |
| Aplastic anemia | D000741 | — | D61.9 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Itacitinib |
| INN | itacitinib |
| Description | Itacitinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against tyrosine-protein kinase JAK1. In addition, it is known to target tyrosine-protein kinase JAK2. |
| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors: tyrosine kinase inhibitors; janus kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N#CCC1(n2cc(-c3ncnc4[nH]ccc34)cn2)CN(C2CCN(C(=O)c3ccnc(C(F)(F)F)c3F)CC2)C1 |
Identifiers
| PDB | — |
| CAS-ID | 1334298-90-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3622820 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 19J3781LPM (ChemIDplus, GSRS) |
Target
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247 adverse events reported
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