Itacitinib
Itacitinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against tyrosine-protein kinase JAK1. In addition, it is known to target tyrosine-protein kinase JAK2.
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54 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Graft vs host disease | D006086 | — | D89.81 | 8 | 9 | 2 | — | — | 16 |
| Bronchiolitis obliterans syndrome | D000092122 | — | — | 2 | 5 | 1 | — | — | 6 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 6 | 6 | — | — | — | 9 |
| Primary myelofibrosis | D055728 | — | D47.4 | — | 6 | — | — | — | 6 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 5 | — | — | — | 5 |
| Syndrome | D013577 | — | — | 3 | 4 | — | — | — | 5 |
| Leukemia | D007938 | — | C95 | 3 | 2 | — | — | — | 5 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 1 | 4 | — | — | — | 5 |
| B-cell lymphoma | D016393 | — | — | 3 | 4 | — | — | — | 5 |
| Myelodysplastic syndromes | D009190 | — | D46 | 2 | 2 | — | — | — | 4 |
| Hematologic neoplasms | D019337 | — | — | 1 | 3 | — | — | — | 4 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 2 | 3 | — | — | — | 4 |
Show 29 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Melanoma | D008545 | — | — | 2 | — | — | — | — | 2 |
| Prolymphocytic leukemia t-cell | D015461 | — | C91.6 | 2 | — | — | — | — | 2 |
| Prolymphocytic leukemia | D015463 | — | — | 2 | — | — | — | — | 2 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | — | — | — | — | 1 |
| Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | — | 1 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 1 | — | — | — | — | 1 |
| Head and neck neoplasms | D006258 | — | — | 1 | — | — | — | — | 1 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | — | — | — | — | 1 |
| Myeloid leukemia | D007951 | — | C92 | 1 | — | — | — | — | 1 |
| Carcinoma | D002277 | — | C80.0 | 1 | — | — | — | — | 1 |
Show 11 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anemia | D000740 | HP_0001903 | D64.9 | — | — | — | — | 1 | 1 |
| Aplastic anemia | D000741 | HP_0001915 | D61.9 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Itacitinib |
| INN | itacitinib |
| Description | Itacitinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against tyrosine-protein kinase JAK1. In addition, it is known to target tyrosine-protein kinase JAK2. |
| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors: tyrosine kinase inhibitors; janus kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N#CCC1(n2cc(-c3ncnc4[nH]ccc34)cn2)CN(C2CCN(C(=O)c3ccnc(C(F)(F)F)c3F)CC2)C1 |
Identifiers
| PDB | — |
| CAS-ID | 1334298-90-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3622820 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 19J3781LPM (ChemIDplus, GSRS) |
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Safety
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241 adverse events reported
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