Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Graft vs host disease | D006086 | — | D89.81 | 8 | 8 | 2 | — | — | 15 |
Bronchiolitis obliterans syndrome | D000092122 | — | D89.811 | 1 | 5 | 1 | — | — | 5 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Neoplasms | D009369 | — | C80 | 6 | 5 | — | — | — | 8 |
Primary myelofibrosis | D055728 | — | D47.4 | — | 6 | — | — | — | 6 |
Non-small-cell lung carcinoma | D002289 | — | — | 1 | 5 | — | — | — | 5 |
Myeloproliferative disorders | D009196 | — | D47.1 | 1 | 4 | — | — | — | 5 |
Syndrome | D013577 | — | — | 3 | 3 | — | — | — | 4 |
Leukemia | D007938 | — | C95 | 2 | 2 | — | — | — | 4 |
Myelodysplastic syndromes | D009190 | — | D46 | 2 | 2 | — | — | — | 4 |
Hematologic neoplasms | D019337 | — | — | 1 | 3 | — | — | — | 4 |
Hodgkin disease | D006689 | — | C81 | 3 | 2 | — | — | — | 4 |
B-cell lymphoma | D016393 | — | — | 3 | 3 | — | — | — | 4 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Melanoma | D008545 | — | — | 2 | — | — | — | — | 2 |
Prolymphocytic leukemia t-cell | D015461 | — | C91.6 | 2 | — | — | — | — | 2 |
B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | — | — | — | — | 1 |
Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 1 | — | — | — | — | 1 |
Mantle-cell lymphoma | D020522 | — | C83.1 | 1 | — | — | — | — | 1 |
Refractory anemia with excess of blasts | D000754 | — | D46.2 | 1 | — | — | — | — | 1 |
Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | — | — | — | — | 1 |
Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | — | 1 |
Endometrial neoplasms | D016889 | EFO_0004230 | — | 1 | — | — | — | — | 1 |
Head and neck neoplasms | D006258 | — | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Anemia | D000740 | EFO_0004272 | D64.9 | — | — | — | — | 1 | 1 |
Aplastic anemia | D000741 | — | D61.9 | — | — | — | — | 1 | 1 |
Drug common name | Itacitinib |
INN | itacitinib |
Description | Itacitinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against tyrosine-protein kinase JAK1. In addition, it is known to target tyrosine-protein kinase JAK2. |
Classification | Small molecule |
Drug class | tyrosine kinase inhibitors: tyrosine kinase inhibitors; janus kinase inhibitors |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | N#CCC1(n2cc(-c3ncnc4[nH]ccc34)cn2)CN(C2CCN(C(=O)c3ccnc(C(F)(F)F)c3F)CC2)C1 |
PDB | — |
CAS-ID | 1334298-90-6 |
RxCUI | — |
ChEMBL ID | CHEMBL3622820 |
ChEBI ID | — |
PubChem CID | — |
DrugBank | — |
UNII ID | 19J3781LPM (ChemIDplus, GSRS) |