Isradipine
Isradipine (isradipine) is a small molecule pharmaceutical. Isradipine was first approved as Dynacirc on 1990-12-20. It is used to treat hypertension and variant angina pectoris in the USA. It is known to target voltage-dependent L-type calcium channel subunit alpha-1F, voltage-dependent L-type calcium channel subunit alpha-1D, voltage-dependent L-type calcium channel subunit alpha-1S, and voltage-dependent L-type calcium channel subunit alpha-1C.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Isradipine (discontinued: Dynacirc, Isradipine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Isradipine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DYNACIRC CR | GSK | N-020336 DISCN | 1994-06-01 | 2 products, RLD |
| DYNACIRC | Smithkline Beecham | N-019546 DISCN | 1990-12-20 | 2 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| isradipine | ANDA | 2023-11-30 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hypertension | EFO_0000537 | D006973 | I10 |
| variant angina pectoris | — | D000788 | I20.1 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
16 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | — | 1 | 1 | — | 4 | 5 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 2 | 1 | — | 1 | 4 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | 2 | 1 | — | — | — | 2 |
| Depression | D003863 | — | F33.9 | — | 1 | — | — | — | 1 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | — | 1 |
| Tobacco use disorder | D014029 | — | F17 | 1 | — | — | — | — | 1 |
| Cigarette smoking | D000073865 | — | — | 1 | — | — | — | — | 1 |
| Smoking | D012907 | EFO_0004318 | — | 1 | — | — | — | — | 1 |
| Smoking cessation | D016540 | EFO_0004319 | — | 1 | — | — | — | — | 1 |
| Craving | D066249 | — | — | 1 | — | — | — | — | 1 |
| Smoking reduction | D000074264 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | — | — | — | — | — | 1 | 1 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | — | — | — | — | 1 | 1 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | — | — | 1 | 1 |
| Psychotic disorders | D011618 | — | F20.81 | — | — | — | — | 1 | 1 |
| Disease progression | D018450 | — | — | — | — | — | — | 1 | 1 |
| Recurrence | D012008 | — | — | — | — | — | — | 1 | 1 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | — | — | — | 1 | 1 |
| Ovarian epithelial carcinoma | D000077216 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Isradipine |
| INN | isradipine |
| Description | Isradipine is an isopropyl ester, a methyl ester, a dihydropyridine and a benzoxadiazole. |
| Classification | Small molecule |
| Drug class | phenylpyridine vasodilators; tricyclic compounds |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc2nonc12 |
Identifiers
| PDB | — |
| CAS-ID | 75695-93-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1648 |
| ChEBI ID | — |
| PubChem CID | 3784 |
| DrugBank | DB00270 |
| UNII ID | YO1UK1S598 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CACNA1F
CACNA1F
CACNA1D
CACNA1D
CACNA1S
CACNA1S
CACNA1C
CACNA1C
Organism
Homo sapiens
Gene name
CACNA1F
Gene synonyms
CACNAF1
NCBI Gene ID
Protein name
voltage-dependent L-type calcium channel subunit alpha-1F
Protein synonyms
calcium channel, voltage-dependent, L type, alpha 1F subunit, Voltage-gated calcium channel subunit alpha Cav1.4
Uniprot ID
Mouse ortholog
Cacna1f (54652)
voltage-dependent L-type calcium channel subunit alpha-1F (Q9JIS7)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Isradipine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,139 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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317 adverse events reported
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