Isoproterenol - PharmaKB

Isoproterenol

Duo-medihaler, Isoproterenol, Medihaler-iso, Norisodrine (isoproterenol) is a small molecule pharmaceutical. Isoproterenol was first approved as Mucomyst w/ isoproterenol on 1982-01-01. It is used to treat adams-stokes syndrome, bradycardia, heart arrest, hemorrhagic shock, and low cardiac output amongst others in the USA. The pharmaceutical is active against beta-2 adrenergic receptor and beta-1 adrenergic receptor. In addition, it is known to target beta-3 adrenergic receptor.

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Clinical

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Target

Variants

Financial

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Events Timeline

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Events

FDA approval date

EMA approval date

Patent expiration date

Study first post date

Last update post date

Start date

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Completion date

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Commercial

Therapeutic Areas

Therapeutic Area	MeSH
infections	D007239
cardiovascular diseases	D002318
signs and symptoms pathological conditions	D013568

Trade Name

FDA

EMA

Isoproterenol (discontinued: Aerolone, Isoproterenol, Isuprel, Norisodrine, Norisodrine aerotrol, Vapo-iso)

Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Isoproterenol sulfate

Tradename	Company	Number	Date	Products
MEDIHALER-ISO	3M	N-010375 DISCN	1982-01-01	1 products
NORISODRINE	AbbVie	N-006905 DISCN	1982-01-01	2 products

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Isoproterenol hydrochloride

Tradename	Company	Number	Date	Products
ISOPROTERENOL HYDROCHLORIDE	3M	N-010375 DISCN	1982-01-01	1 products
NORISODRINE AEROTROL	Abbott Biotherapeutics	N-016814 DISCN	1982-01-01	1 products
ISUPREL	Bausch Health Companies	N-010515 DISCN	1982-01-01	1 products, RLD
VAPO-ISO	Fisons	N-016813 DISCN	1982-01-01	1 products
AEROLONE	Eli Lilly	N-007245 DISCN	1982-01-01	1 products
ISUPREL	Sanofi	N-006327 DISCN	1982-01-01	2 products
ISUPREL	Sanofi	N-006328 DISCN	1982-01-01	2 products
ISUPREL	Sanofi	N-011178 DISCN	1982-01-01	1 products

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Isoproterenol hydrochloride

Phenylephrine bitartrate

Tradename	Company	Number	Date	Products
DUO-MEDIHALER	3M	N-013296 DISCN	1982-01-01	1 products

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Acetylcysteine

Isoproterenol hydrochloride

Tradename	Company	Number	Date	Products
MUCOMYST W/ ISOPROTERENOL	Mead Johnson Nutrition	N-017366 DISCN	1982-01-01	1 products

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Labels

FDA

EMA

Brand Name	Status	Last Update
isoproterenol	ANDA	2024-01-14
isoproterenol hydrochloride	ANDA	2025-01-06

Indications

FDA

EMA

Indication	Ontology	MeSH	ICD-10
septic shock	—	D012772	A48.3
low cardiac output	—	D002303	—
bradycardia	—	D001919	R00.1
heart arrest	EFO_0009492	D006323	I46
ventricular fibrillation	EFO_0004287	D014693	I49.01
hemorrhagic shock	—	D012771	—
torsades de pointes	EFO_0005307	D016171	I47.21
adams-stokes syndrome	—	D000219	I45.9
hypotension	EFO_0005251	D007022	I95
pruritus ani	—	D011538	L29.0

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Agency Specific

FDA

EMA

No data

Patent Expiration

No data

ATC Codes

C: Cardiovascular system drugs

— C01: Cardiac therapy drugs

— C01C: Cardiac stimulants excl. cardiac glycosides

— C01CA: Adrenergic and dopaminergic cardiac stimulants

— C01CA02: Isoprenaline

R: Respiratory system drugs

— R03: Drugs for obstructive airway diseases

— R03A: Adrenergics, inhalants

— R03AB: Non-selective beta-adrenoreceptor agonist inhalants

— R03AB02: Isoprenaline

— R03AK: Adrenergics inhalants in combination with corticosteroids or other drugs, excl. anticholinergics

— R03AK02: Isoprenaline and other drugs for obstructive airway diseases

— R03C: Adrenergics for systemic use

— R03CB: Non-selective beta-adrenoreceptor agonists for systemic use

— R03CB01: Isoprenaline

— R03CB51: Isoprenaline, combinations

HCPCS

Code	Description
J7657	Isoproterenol hcl, inhalation solution, compounded product, administered through dme, concentrated form, per milligram
J7658	Isoproterenol hcl, inhalation solution, fda-approved final product, non-compounded, administered through dme, concentrated form, per milligram
J7659	Isoproterenol hcl, inhalation solution, fda-approved final product, non-compounded, administered through dme, unit dose form, per milligram
J7660	Isoproterenol hcl, inhalation solution, compounded product, administered through dme, unit dose form, per milligram

Clinical

Clinical Trials

1184 clinical trials

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Indications Phases 4

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Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Chronic obstructive pulmonary disease	D029424	EFO_0000341	J44.9	—	—	1	—	—	1
Lung diseases	D008171	EFO_0003818	J98.4	—	—	1	—	—	1
Obstructive lung diseases	D008173	—	—	—	—	1	—	—	1

Indications Phases 2

No data

Indications Phases 1

No data

Indications Without Phase

No data

Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	Isoproterenol
INN	isoprenaline
Description	Isoprenaline is a secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders. It has a role as a sympathomimetic agent, a beta-adrenergic agonist, a bronchodilator agent and a cardiotonic drug. It is a member of catechols, a secondary amino compound and a secondary alcohol.
Classification	Small molecule
Drug class	—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	CC(C)NCC(O)c1ccc(O)c(O)c1

Identifiers

PDB	—
CAS-ID	7683-59-2
RxCUI	—
ChEMBL ID	CHEMBL434
ChEBI ID	64317
PubChem CID	3779
DrugBank	DB01064
UNII ID	L628TT009W (ChemIDplus, GSRS)

Target

Agency Approved

ADRB2

ADRB1

Organism

Homo sapiens

Gene name

ADRB2

Gene synonyms

ADRB2R, B2AR

NCBI Gene ID

154

Protein name

beta-2 adrenergic receptor

Protein synonyms

adrenergic, beta-2-, receptor, surface, adrenoceptor beta 2 surface, Beta-2 adrenoceptor, Beta-2 adrenoreceptor, catecholamine receptor

Uniprot ID

Q9UMZ5

Mouse ortholog

Adrb2 (11555)

beta-2 adrenergic receptor (Q8BH38)

Alternate

ADRB3

Organism

Homo sapiens

Gene name

ADRB3

Gene synonyms

ADRB3R, B3AR

NCBI Gene ID

155

Protein name

beta-3 adrenergic receptor

Protein synonyms

adrenergic, beta-3-, receptor, Beta-3 adrenoceptor, Beta-3 adrenoreceptor

Uniprot ID

Q4JFT4

Mouse ortholog

Adrb3 (11556)

beta-3 adrenergic receptor (Q9QZ98)

Variants

No data

Financial

Revenue by drug

€

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No data

Estimated US medical usage

Isoproterenol

Total medical expenditures per year (USD, in millions)

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Number of persons purchased

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Number of purchases

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Refill frequency

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Price per prescription (USD)

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Trends

PubMed Central

Top Terms for Disease or Syndrome:

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Additional graphs summarizing 54,657 documents

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Safety

Black-box Warning

No Black-box warning

Adverse Events

Top Adverse Reactions

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397 adverse events reported

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