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Drug ReportsIsoproterenol
Isoproterenol
Duo-medihaler, Isoproterenol, Medihaler-iso, Norisodrine (isoproterenol) is a small molecule pharmaceutical. Isoproterenol was first approved as Mucomyst w/ isoproterenol on 1982-01-01. It is used to treat adams-stokes syndrome, bradycardia, heart arrest, hemorrhagic shock, and low cardiac output amongst others in the USA. The pharmaceutical is active against beta-2 adrenergic receptor and beta-1 adrenergic receptor. In addition, it is known to target beta-3 adrenergic receptor.
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Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
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Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Isoproterenol (discontinued: Aerolone, Isoproterenol, Isuprel, Norisodrine, Norisodrine aerotrol, Vapo-iso)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Isoproterenol sulfate
Tradename
Company
Number
Date
Products
MEDIHALER-ISO3MN-010375 DISCN1982-01-01
1 products
NORISODRINEAbbVieN-006905 DISCN1982-01-01
2 products
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Isoproterenol hydrochloride
Tradename
Company
Number
Date
Products
ISOPROTERENOL HYDROCHLORIDE3MN-010375 DISCN1982-01-01
1 products
NORISODRINE AEROTROLAbbott BiotherapeuticsN-016814 DISCN1982-01-01
1 products
ISUPRELBausch Health CompaniesN-010515 DISCN1982-01-01
1 products, RLD
VAPO-ISOFisonsN-016813 DISCN1982-01-01
1 products
AEROLONEEli LillyN-007245 DISCN1982-01-01
1 products
ISUPRELSanofiN-006327 DISCN1982-01-01
2 products
ISUPRELSanofiN-006328 DISCN1982-01-01
2 products
ISUPRELSanofiN-011178 DISCN1982-01-01
1 products
Hide discontinued
Isoproterenol hydrochloride
+
Phenylephrine bitartrate
Tradename
Company
Number
Date
Products
DUO-MEDIHALER3MN-013296 DISCN1982-01-01
1 products
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Acetylcysteine
+
Isoproterenol hydrochloride
Tradename
Company
Number
Date
Products
MUCOMYST W/ ISOPROTERENOLMead Johnson NutritionN-017366 DISCN1982-01-01
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
isoproterenolANDA2024-01-14
isoproterenol hydrochlorideANDA2025-01-06
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
C01: Cardiac therapy drugs
C01C: Cardiac stimulants excl. cardiac glycosides
C01CA: Adrenergic and dopaminergic cardiac stimulants
C01CA02: Isoprenaline
R: Respiratory system drugs
R03: Drugs for obstructive airway diseases
R03A: Adrenergics, inhalants
R03AB: Non-selective beta-adrenoreceptor agonist inhalants
R03AB02: Isoprenaline
R03AK: Adrenergics inhalants in combination with corticosteroids or other drugs, excl. anticholinergics
R03AK02: Isoprenaline and other drugs for obstructive airway diseases
R03C: Adrenergics for systemic use
R03CB: Non-selective beta-adrenoreceptor agonists for systemic use
R03CB01: Isoprenaline
R03CB51: Isoprenaline, combinations
HCPCS
Code
Description
J7657
Isoproterenol hcl, inhalation solution, compounded product, administered through dme, concentrated form, per milligram
J7658
Isoproterenol hcl, inhalation solution, fda-approved final product, non-compounded, administered through dme, concentrated form, per milligram
J7659
Isoproterenol hcl, inhalation solution, fda-approved final product, non-compounded, administered through dme, unit dose form, per milligram
J7660
Isoproterenol hcl, inhalation solution, compounded product, administered through dme, unit dose form, per milligram
Clinical
Clinical Trials
1191 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Lung neoplasmsD008175C34.9048881414133
Breast neoplasmsD001943EFO_0003869C5041761569129
Non-small-cell lung carcinomaD00228943791815127
LymphomaD008223C85.9494741289
B-cell lymphomaD01639313151124
Large b-cell lymphoma diffuseD016403C83.39162123
SyndromeD013577831414
Atrial fibrillationD001281EFO_0000275I48.0111012
OsteoarthritisD010003EFO_0002506M15-M191311611
Knee osteoarthritisD020370EFO_0004616M17121610
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C801796125211
CarcinomaD002277C80.021438262
Multiple myelomaD009101C90.027264348
Plasma cell neoplasmsD05421924254244
Ovarian neoplasmsD010051EFO_0003893C5624292144
Pancreatic neoplasmsD010190EFO_0003860C252229242
SarcomaD01250916233541
Small cell lung carcinomaD0557521629438
Prostatic neoplasmsD011471C611819234
AdenocarcinomaD00023014184232
Show 59 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LeukemiaD007938C95261432
Non-hodgkin lymphomaD008228C85.9211331
Myeloid leukemia acuteD015470C92.016717
Myeloid leukemiaD007951C9215716
RecurrenceD012008811215
Urinary bladder neoplasmsD001749C6771315
Fallopian tube neoplasmsD00518561114
Myelodysplastic syndromesD009190D469612
PreleukemiaD0112898511
Uterine cervical neoplasmsD0025838811
Show 167 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Postoperative painD010149G89.18167
ObesityD009765EFO_0001073E66.9235
HivD006678O98.7224
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.044
PapillomaD010212123
Coxsackievirus infectionsD003384EFO_0007226B34.133
Sickle cell anemiaD000755EFO_0000697D57112
ThalassemiaD013789EFO_1001996D56112
Lip neoplasmsD008048C0022
Male genital neoplasmsD00583422
Show 67 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cystic fibrosisD003550EFO_0000390E8444
BursitisD002062EFO_1000941M71.944
Heart failureD006333EFO_0003144I5033
Cardiac arrhythmiasD001145EFO_0004269I49.933
TachycardiaD013610R00.033
Anxiety disordersD001008EFO_0006788F41.133
NeuralgiaD009437EFO_000943033
AnalgesiaD00069833
AnemiaD000740EFO_0004272D64.922
Prostatic hyperplasiaD011470EFO_0000284N4022
Show 140 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameIsoproterenol
INNisoprenaline
Description
Isoprenaline is a secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders. It has a role as a sympathomimetic agent, a beta-adrenergic agonist, a bronchodilator agent and a cardiotonic drug. It is a member of catechols, a secondary amino compound and a secondary alcohol.
Classification
Small molecule
Drug class
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC(C)NCC(O)c1ccc(O)c(O)c1
Identifiers
PDB
CAS-ID7683-59-2
RxCUI
ChEMBL IDCHEMBL434
ChEBI ID64317
PubChem CID3779
DrugBankDB01064
UNII IDL628TT009W (ChemIDplus, GSRS)
Target
Agency Approved
ADRB2
ADRB2
ADRB1
ADRB1
Organism
Homo sapiens
Gene name
ADRB2
Gene synonyms
ADRB2R, B2AR
NCBI Gene ID
Protein name
beta-2 adrenergic receptor
Protein synonyms
adrenergic, beta-2-, receptor, surface, adrenoceptor beta 2 surface, Beta-2 adrenoceptor, Beta-2 adrenoreceptor, catecholamine receptor
Uniprot ID
Mouse ortholog
Adrb2 (11555)
beta-2 adrenergic receptor (Q8BH38)
Alternate
ADRB3
ADRB3
Organism
Homo sapiens
Gene name
ADRB3
Gene synonyms
ADRB3R, B3AR
NCBI Gene ID
Protein name
beta-3 adrenergic receptor
Protein synonyms
adrenergic, beta-3-, receptor, Beta-3 adrenoceptor, Beta-3 adrenoreceptor
Uniprot ID
Mouse ortholog
Adrb3 (11556)
beta-3 adrenergic receptor (Q9QZ98)
Variants
No data
Financial
Revenue by drug
$
£
No data
Estimated US medical usage
Isoproterenol
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 54,895 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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405 adverse events reported
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