Isoproterenol
Duo-medihaler, Isoproterenol, Medihaler-iso, Norisodrine (isoproterenol) is a small molecule pharmaceutical. Isoproterenol was first approved as Mucomyst w/ isoproterenol on 1982-01-01. It is used to treat adams-stokes syndrome, bradycardia, heart arrest, hemorrhagic shock, and low cardiac output amongst others in the USA. The pharmaceutical is active against beta-2 adrenergic receptor and beta-1 adrenergic receptor. In addition, it is known to target beta-3 adrenergic receptor.
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Acetylcysteine
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Isoproterenol hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| MUCOMYST W/ ISOPROTERENOL | Mead Johnson Nutrition | N-017366 DISCN | 1982-01-01 | 1 products |
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Isoproterenol hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ISOPROTERENOL HYDROCHLORIDE | 3M | N-010375 DISCN | 1982-01-01 | 1 products |
| NORISODRINE AEROTROL | Abbott Biotherapeutics | N-016814 DISCN | 1982-01-01 | 1 products |
| ISUPREL | Bausch Health Companies | N-010515 DISCN | 1982-01-01 | 1 products, RLD |
| VAPO-ISO | Fisons | N-016813 DISCN | 1982-01-01 | 1 products |
| AEROLONE | Eli Lilly | N-007245 DISCN | 1982-01-01 | 1 products |
| ISUPREL | Sanofi | N-006327 DISCN | 1982-01-01 | 2 products |
| ISUPREL | Sanofi | N-006328 DISCN | 1982-01-01 | 2 products |
| ISUPREL | Sanofi | N-011178 DISCN | 1982-01-01 | 1 products |
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Isoproterenol hydrochloride
+
Phenylephrine bitartrate
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| isoproterenol | ANDA | 2024-01-14 |
| isoproterenol hydrochloride | ANDA | 2024-01-02 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C01: Cardiac therapy drugs
— C01C: Cardiac stimulants excl. cardiac glycosides
— C01CA: Adrenergic and dopaminergic cardiac stimulants
— C01CA02: Isoprenaline
R: Respiratory system drugs
— R03: Drugs for obstructive airway diseases
— R03A: Adrenergics, inhalants
— R03AB: Non-selective beta-adrenoreceptor agonist inhalants
— R03AB02: Isoprenaline
— R03AK: Adrenergics inhalants in combination with corticosteroids or other drugs, excl. anticholinergics
— R03AK02: Isoprenaline and other drugs for obstructive airway diseases
— R03C: Adrenergics for systemic use
— R03CB: Non-selective beta-adrenoreceptor agonists for systemic use
— R03CB01: Isoprenaline
— R03CB51: Isoprenaline, combinations
HCPCS
Code | Description |
|---|---|
| J7657 | Isoproterenol hcl, inhalation solution, compounded product, administered through dme, concentrated form, per milligram |
| J7658 | Isoproterenol hcl, inhalation solution, fda-approved final product, non-compounded, administered through dme, concentrated form, per milligram |
| J7659 | Isoproterenol hcl, inhalation solution, fda-approved final product, non-compounded, administered through dme, unit dose form, per milligram |
| J7660 | Isoproterenol hcl, inhalation solution, compounded product, administered through dme, unit dose form, per milligram |
Clinical
Clinical Trials
41 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | 1 | — | 1 | 6 | 8 |
| Vasodilation | D014664 | — | — | 1 | — | — | 1 | — | 2 |
| Vasoconstriction | D014661 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Retinopathy of prematurity | D012178 | EFO_1001158 | H35.1 | — | 2 | 1 | — | — | 2 |
| Kidney calculi | D007669 | EFO_0004253 | N20 | — | 2 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lipoma | D008067 | — | D17.9 | 1 | 1 | — | — | — | 1 |
| Ureteroscopy | D018666 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Autonomic nervous system diseases | D001342 | EFO_0009532 | G90 | 1 | — | — | — | 1 | 2 |
| Orthostatic intolerance | D054971 | — | — | 1 | — | — | — | 1 | 2 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 2 | — | — | — | — | 2 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Orthostatic hypotension | D007024 | — | I95.1 | 1 | — | — | — | — | 1 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | — | — | — | — | 1 |
| Pure autonomic failure | D054970 | — | — | 1 | — | — | — | — | 1 |
| Shy-drager syndrome | D012791 | EFO_1001050 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | — | — | — | — | 4 | 4 |
| Heart failure | D006333 | HP_0001635 | I50 | — | — | — | — | 2 | 2 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | — | — | — | 2 | 2 |
| Postural orthostatic tachycardia syndrome | D054972 | — | G90.A | — | — | — | — | 2 | 2 |
| Sudden death cardiac | D016757 | EFO_0004278 | — | — | — | — | — | 2 | 2 |
| Anorexia nervosa | D000856 | EFO_0004215 | F50.0 | — | — | — | — | 2 | 2 |
| Hypotension | D007022 | EFO_0005251 | I95 | — | — | — | — | 1 | 1 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | — | — | 1 | 1 |
| Tachycardia | D013610 | HP_0001649 | R00.0 | — | — | — | — | 1 | 1 |
| Primary dysautonomias | D054969 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Isoproterenol |
| INN | isoprenaline |
| Description | Isoprenaline is a secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders. It has a role as a sympathomimetic agent, a beta-adrenergic agonist, a bronchodilator agent and a cardiotonic drug. It is a member of catechols, a secondary amino compound and a secondary alcohol. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)NCC(O)c1ccc(O)c(O)c1 |
Identifiers
| PDB | — |
| CAS-ID | 7683-59-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL434 |
| ChEBI ID | 64317 |
| PubChem CID | 3779 |
| DrugBank | DB01064 |
| UNII ID | L628TT009W (ChemIDplus, GSRS) |
Target
Agency Approved
ADRB2
ADRB2
ADRB1
ADRB1
Organism
Homo sapiens
Gene name
ADRB2
Gene synonyms
ADRB2R, B2AR
NCBI Gene ID
Protein name
beta-2 adrenergic receptor
Protein synonyms
adrenergic, beta-2-, receptor, surface, adrenoceptor beta 2 surface, Beta-2 adrenoceptor, Beta-2 adrenoreceptor, catecholamine receptor
Uniprot ID
Mouse ortholog
Adrb2 (11555)
beta-2 adrenergic receptor (Q8BH38)
Variants
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Isoproterenol
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Trends
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Safety
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283 adverse events reported
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