Isoproterenol - PharmaKB

Isoproterenol

Duo-medihaler, Isoproterenol, Medihaler-iso, Norisodrine (isoproterenol) is a small molecule pharmaceutical. Isoproterenol was first approved as Mucomyst w/ isoproterenol on 1982-01-01. It is used to treat adams-stokes syndrome, bradycardia, heart arrest, hemorrhagic shock, and low cardiac output amongst others in the USA. The pharmaceutical is active against beta-2 adrenergic receptor and beta-1 adrenergic receptor. In addition, it is known to target beta-3 adrenergic receptor.

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Clinical

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Commercial

Therapeutic Areas

Therapeutic Area	MeSH
infections	D007239
cardiovascular diseases	D002318
signs and symptoms pathological conditions	D013568

Trade Name

FDA

EMA

Isoproterenol (discontinued: Aerolone, Isoproterenol, Isuprel, Norisodrine, Norisodrine aerotrol, Vapo-iso)

Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Isoproterenol sulfate

Tradename	Company	Number	Date	Products
MEDIHALER-ISO	3M	N-010375 DISCN	1982-01-01	1 products
NORISODRINE	AbbVie	N-006905 DISCN	1982-01-01	2 products

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Isoproterenol hydrochloride

Tradename	Company	Number	Date	Products
ISOPROTERENOL HYDROCHLORIDE	3M	N-010375 DISCN	1982-01-01	1 products
NORISODRINE AEROTROL	Abbott Biotherapeutics	N-016814 DISCN	1982-01-01	1 products
ISUPREL	Bausch Health Companies	N-010515 DISCN	1982-01-01	1 products, RLD
VAPO-ISO	Fisons	N-016813 DISCN	1982-01-01	1 products
AEROLONE	Eli Lilly	N-007245 DISCN	1982-01-01	1 products
ISUPREL	Sanofi	N-006327 DISCN	1982-01-01	2 products
ISUPREL	Sanofi	N-006328 DISCN	1982-01-01	2 products
ISUPREL	Sanofi	N-011178 DISCN	1982-01-01	1 products

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Isoproterenol hydrochloride

Phenylephrine bitartrate

Tradename	Company	Number	Date	Products
DUO-MEDIHALER	3M	N-013296 DISCN	1982-01-01	1 products

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Acetylcysteine

Isoproterenol hydrochloride

Tradename	Company	Number	Date	Products
MUCOMYST W/ ISOPROTERENOL	Mead Johnson Nutrition	N-017366 DISCN	1982-01-01	1 products

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Labels

FDA

EMA

Brand Name	Status	Last Update
isoproterenol	ANDA	2024-01-14
isoproterenol hydrochloride	ANDA	2026-03-17

Indications

FDA

EMA

Indication	Ontology	MeSH	ICD-10
septic shock	—	D012772	A48.3
low cardiac output	—	D002303	—
bradycardia	—	D001919	R00.1
heart arrest	EFO_0009492	D006323	I46
ventricular fibrillation	EFO_0004287	D014693	I49.01
hemorrhagic shock	—	D012771	—
torsades de pointes	EFO_0005307	D016171	I47.21
adams-stokes syndrome	—	D000219	I45.9
hypotension	EFO_0005251	D007022	I95
pruritus ani	—	D011538	L29.0

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Agency Specific

FDA

EMA

No data

Patent Expiration

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ATC Codes

C: Cardiovascular system drugs

— C01: Cardiac therapy drugs

— C01C: Cardiac stimulants excl. cardiac glycosides

— C01CA: Adrenergic and dopaminergic cardiac stimulants

— C01CA02: Isoprenaline

R: Respiratory system drugs

— R03: Drugs for obstructive airway diseases

— R03A: Adrenergics, inhalants

— R03AB: Non-selective beta-adrenoreceptor agonist inhalants

— R03AB02: Isoprenaline

— R03AK: Adrenergics inhalants in combination with corticosteroids or other drugs, excl. anticholinergics

— R03AK02: Isoprenaline and other drugs for obstructive airway diseases

— R03C: Adrenergics for systemic use

— R03CB: Non-selective beta-adrenoreceptor agonists for systemic use

— R03CB01: Isoprenaline

— R03CB51: Isoprenaline, combinations

HCPCS

Code	Description
J7657	Isoproterenol hcl, inhalation solution, compounded product, administered through dme, concentrated form, per milligram
J7658	Isoproterenol hcl, inhalation solution, fda-approved final product, non-compounded, administered through dme, concentrated form, per milligram
J7659	Isoproterenol hcl, inhalation solution, fda-approved final product, non-compounded, administered through dme, unit dose form, per milligram
J7660	Isoproterenol hcl, inhalation solution, compounded product, administered through dme, unit dose form, per milligram

Clinical

Clinical Trials

1293 clinical trials

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Indications Phases 4

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Non-small-cell lung carcinoma	D002289	—	—	53	85	19	1	6	140
Breast neoplasms	D001943	EFO_0003869	C50	41	75	16	6	10	129
Lymphoma	D008223	—	C85.9	43	37	1	1	1	73
Large b-cell lymphoma diffuse	D016403	—	C83.3	10	16	2	1	1	24
B-cell lymphoma	D016393	—	—	11	13	1	1	1	22
Atrial fibrillation	D001281	EFO_0000275	I48.0	—	1	—	1	10	12
Knee osteoarthritis	D020370	EFO_0004616	M17	1	2	—	1	6	10
Biliary tract neoplasms	D001661	—	C24.9	4	4	4	1	—	10
Syndrome	D013577	—	—	6	3	—	1	1	9
Osteoarthritis	D010003	EFO_0002506	M15-M19	—	1	1	1	7	9

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Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Neoplasms	D009369	—	C80	186	72	3	—	5	226
Lung neoplasms	D008175	—	C34.90	34	62	5	—	2	86
Multiple myeloma	D009101	—	C90.0	27	25	5	—	2	48
Ovarian neoplasms	D010051	EFO_0003893	C56	25	28	2	—	1	43
Pancreatic neoplasms	D010190	EFO_0003860	C25	24	28	2	—	—	43
Neoplasm metastasis	D009362	EFO_0009708	—	17	25	4	—	—	41
Small cell lung carcinoma	D055752	—	—	18	29	3	—	—	39
Sarcoma	D012509	—	—	16	22	3	—	4	39
Carcinoma	D002277	—	C80.0	11	25	5	—	2	36
Prostatic neoplasms	D011471	—	C61	20	18	2	—	—	35

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Indications Phases 2

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Leukemia	D007938	—	C95	25	14	—	—	—	31
Non-hodgkin lymphoma	D008228	—	C85.9	20	12	—	—	—	30
Urinary bladder neoplasms	D001749	—	C67	10	11	—	—	—	16
Myeloid leukemia	D007951	—	C92	13	7	—	—	—	14
Mesothelioma	D008654	—	C45	9	9	—	—	—	14
Myelodysplastic syndromes	D009190	—	D46	9	6	—	—	—	12
Uterine cervical neoplasms	D002583	—	—	9	9	—	—	—	12
Renal cell carcinoma	D002292	EFO_0000376	—	8	4	—	—	1	11
Follicular lymphoma	D008224	—	C82	4	9	—	—	—	10
Urologic neoplasms	D014571	—	C64-C68	5	7	—	—	—	9

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Indications Phases 1

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Postoperative pain	D010149	—	G89.18	1	—	—	—	12	13
Obesity	D009765	EFO_0001073	E66.9	2	—	—	—	3	5
Hiv	D006678	—	O98.7	2	—	—	—	2	4
Precursor cell lymphoblastic leukemia-lymphoma	D054198	—	C91.0	4	—	—	—	—	4
Coxsackievirus infections	D003384	EFO_0007226	B34.1	4	—	—	—	—	4
Papilloma	D010212	—	—	1	—	—	—	2	3
Thalassemia	D013789	EFO_1001996	D56	1	—	—	—	1	2
Hypotension	D007022	EFO_0005251	I95	1	—	—	—	1	2
Chondrosarcoma	D002813	—	—	1	—	—	—	1	2
Autonomic nervous system diseases	D001342	EFO_0009532	G90	1	—	—	—	1	2

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Indications Without Phase

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Conduction anesthesia	D000765	—	—	—	—	—	—	5	5
Heart failure	D006333	EFO_0003144	I50	—	—	—	—	3	3
Shoulder impingement syndrome	D019534	EFO_1001178	M75.4	—	—	—	—	3	3
Cardiac arrhythmias	D001145	EFO_0004269	I49.9	—	—	—	—	3	3
Anxiety disorders	D001008	EFO_0006788	F41.1	—	—	—	—	3	3
Pregnancy	D011247	EFO_0002950	Z33.1	—	—	—	—	3	3
Neuralgia	D009437	EFO_0009430	—	—	—	—	—	3	3
Analgesia	D000698	—	—	—	—	—	—	3	3
Bursitis	D002062	EFO_1000941	M71.9	—	—	—	—	3	3
Anemia	D000740	EFO_0004272	D64.9	—	—	—	—	2	2

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Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	Isoproterenol
INN	isoprenaline
Description	Isoprenaline is a secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders. It has a role as a sympathomimetic agent, a beta-adrenergic agonist, a bronchodilator agent and a cardiotonic drug. It is a member of catechols, a secondary amino compound and a secondary alcohol.
Classification	Small molecule
Drug class	—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	CC(C)NCC(O)c1ccc(O)c(O)c1

Identifiers

PDB	—
CAS-ID	7683-59-2
RxCUI	—
ChEMBL ID	CHEMBL434
ChEBI ID	64317
PubChem CID	3779
DrugBank	DB01064
UNII ID	L628TT009W (ChemIDplus, GSRS)

Target

Agency Approved

ADRB2

ADRB1

Organism

Homo sapiens

Gene name

ADRB2

Gene synonyms

ADRB2R, B2AR

NCBI Gene ID

154

Protein name

beta-2 adrenergic receptor

Protein synonyms

adrenergic, beta-2-, receptor, surface, adrenoceptor beta 2 surface, Beta-2 adrenoceptor, Beta-2 adrenoreceptor, catecholamine receptor

Uniprot ID

Q9UMZ5

Mouse ortholog

Adrb2 (11555)

beta-2 adrenergic receptor (Q8BH38)

Alternate

ADRB3

Organism

Homo sapiens

Gene name

ADRB3

Gene synonyms

ADRB3R, B3AR

NCBI Gene ID

155

Protein name

beta-3 adrenergic receptor

Protein synonyms

adrenergic, beta-3-, receptor, Beta-3 adrenoceptor, Beta-3 adrenoreceptor

Uniprot ID

Q4JFT4

Mouse ortholog

Adrb3 (11556)

beta-3 adrenergic receptor (Q9QZ98)

Variants

No data

Financial

Revenue by drug

€

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No data

Estimated US medical usage

Isoproterenol

Total medical expenditures per year (USD, in millions)

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Number of persons purchased

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Price per prescription (USD)

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Trends

PubMed Central

Top Terms for Disease or Syndrome:

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Safety

Black-box Warning

No Black-box warning

Adverse Events

Top Adverse Reactions

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439 adverse events reported

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