Isoleucine
Isoleucine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target pituitary adenylate cyclase-activating polypeptide type I receptor, vasoactive intestinal polypeptide receptor 1, vasoactive intestinal polypeptide receptor 2, and secretin receptor.
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Commercial
Therapeutic Areas
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Trade Name
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| aminosyn ii | New Drug Application | 2022-05-04 |
| aminosyn-pf | New Drug Application | 2022-07-21 |
| asce plus derma signal kit srlv | unapproved drug other | 2021-11-23 |
| clinimix | New Drug Application | 2021-04-13 |
| clinimix e | New Drug Application | 2021-04-13 |
| clinisol | ANDA | 2018-06-01 |
| exoscrt derma signal kit srlv | unapproved drug other | 2021-11-23 |
| exoscrt derma signal srlv vial 1. lyophilized | unapproved drug other | 2023-01-17 |
| exoscrt derma signal srlv vial 2. diluent | unapproved drug other | 2023-01-17 |
| kabiven | New Drug Application | 2023-08-02 |
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Indications
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Agency Specific
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Clinical
Clinical Trials
49 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fibrosis | D005355 | — | — | — | — | 3 | 2 | 1 | 6 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | 2 | 1 | 1 | 4 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | 1 | 1 | 2 | 4 |
| Brain diseases | D001927 | HP_0001298 | G93.40 | — | — | — | 1 | 1 | 2 |
| Hepatic encephalopathy | D006501 | — | K72.91 | — | — | — | 1 | 1 | 2 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sarcopenia | D055948 | EFO_1000653 | M62.84 | — | — | 2 | — | 3 | 5 |
| Ascites | D001201 | HP_0001541 | R18 | — | — | 1 | — | — | 1 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | — | 1 | — | — | 1 |
| Uterine cervical neoplasms | D002583 | HP_0030159 | — | — | — | 1 | — | — | 1 |
| Kwashiorkor | D007732 | EFO_1001009 | E40 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Muscular atrophy | D009133 | HP_0003202 | — | — | 1 | — | — | 1 | 2 |
| Atrophy | D001284 | — | — | — | 1 | — | — | — | 1 |
| Diarrhea | D003967 | HP_0002014 | R19.7 | — | 1 | — | — | — | 1 |
| Dysentery | D004403 | EFO_1001869 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 1 | — | — | — | 1 | 2 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | — | — | — | 1 | 2 |
| Fatigue | D005221 | HP_0012378 | R53.83 | 1 | — | — | — | — | 1 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | — | — | — | — | 3 | 3 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 2 | 2 |
| Metabolic diseases | D008659 | EFO_0000589 | E88.9 | — | — | — | — | 2 | 2 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | — | — | 2 | 2 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | — | — | 2 | 2 |
| Maple syrup urine disease | D008375 | — | E71.0 | — | — | — | — | 2 | 2 |
| Hyperglycemia | D006943 | HP_0003074 | R73.9 | — | — | — | — | 1 | 1 |
| Amyloidosis | D000686 | EFO_1001875 | E85 | — | — | — | — | 1 | 1 |
| Polyneuropathies | D011115 | EFO_0009562 | A69.22 | — | — | — | — | 1 | 1 |
| Nutritional physiological phenomena | D009747 | — | — | — | — | — | — | 1 | 1 |
Show 18 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Isoleucine |
| INN | isoleucine |
| Description | 2-amino-3-methylpentanoic acid is a branched chain amino acid that consists of 3-methylpentanoic acid bearing an amino substituent at position 2. It is an alpha-amino acid and a branched-chain amino acid. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC[C@H](C)[C@H](N)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 73-32-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1233584 |
| ChEBI ID | 17191 |
| PubChem CID | 791 |
| DrugBank | DB00167 |
| UNII ID | 04Y7590D77 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
ADCYAP1R1
ADCYAP1R1
VIPR1
VIPR1
VIPR2
VIPR2
SCTR
SCTR
Organism
Homo sapiens
Gene name
ADCYAP1R1
Gene synonyms
NCBI Gene ID
Protein name
pituitary adenylate cyclase-activating polypeptide type I receptor
Protein synonyms
adenylate cyclase activating polypeptide 1 (pituitary) receptor type I, PACAP receptor 1, PACAP type I receptor, PACAP-R1, pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop, pituitary adenylate cyclase-activating polypeptide type 1 receptor
Uniprot ID
Mouse ortholog
Adcyap1r1 (11517)
pituitary adenylate cyclase-activating polypeptide type I receptor (P70205)
Variants
No data
Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 86,946 documents
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Safety
Black-box Warning
Black-box warning for: Aminosyn ii
Adverse Events
Top Adverse Reactions
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293 adverse events reported
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