Isoleucine
Isoleucine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target pituitary adenylate cyclase-activating polypeptide type I receptor, vasoactive intestinal polypeptide receptor 1, vasoactive intestinal polypeptide receptor 2, and secretin receptor.
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EMA
Brand Name | Status | Last Update |
|---|---|---|
| aminosyn ii | New Drug Application | 2022-05-04 |
| aminosyn-pf | New Drug Application | 2022-07-21 |
| asce plus derma signal kit srlv | unapproved drug other | 2021-11-23 |
| clinimix | New Drug Application | 2021-04-13 |
| clinimix e | New Drug Application | 2021-04-13 |
| clinisol | ANDA | 2018-06-01 |
| exoscrt derma signal kit srlv | unapproved drug other | 2021-11-23 |
| exoscrt derma signal srlv vial 1. lyophilized | unapproved drug other | 2024-12-09 |
| exoscrt derma signal srlv vial 2. diluent | unapproved drug other | 2024-12-09 |
| ilevro | New Drug Application | 2025-07-16 |
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Clinical
Clinical Trials
171 clinical trials
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Head and neck neoplasms | D006258 | — | — | 1 | 1 | — | — | — | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Isoleucine |
| INN | isoleucine |
| Description | 2-amino-3-methylpentanoic acid is a branched chain amino acid that consists of 3-methylpentanoic acid bearing an amino substituent at position 2. It is an alpha-amino acid and a branched-chain amino acid. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC[C@H](C)[C@H](N)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 73-32-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1233584 |
| ChEBI ID | 17191 |
| PubChem CID | 791 |
| DrugBank | DB00167 |
| UNII ID | 04Y7590D77 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
ADCYAP1R1
ADCYAP1R1
Organism
Homo sapiens
Gene name
ADCYAP1R1
Gene synonyms
NCBI Gene ID
Protein name
pituitary adenylate cyclase-activating polypeptide type I receptor
Protein synonyms
adenylate cyclase activating polypeptide 1 (pituitary) receptor type I, PACAP receptor 1, PACAP type I receptor, PACAP-R1, pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop, pituitary adenylate cyclase-activating polypeptide type 1 receptor
Uniprot ID
Mouse ortholog
Adcyap1r1 (11517)
pituitary adenylate cyclase-activating polypeptide type I receptor (P70205)
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Safety
Black-box Warning
Black-box warning for: Aminosyn ii
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141,617 adverse events reported
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