Iohexol
Omnipaque (iohexol) is a small molecule pharmaceutical. Iohexol was first approved as Omnipaque 180 on 1985-12-26.
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Commercial
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Trade Name
FDA
EMA
Omnipaque (discontinued: Omnipaque, Oraltag)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Iohexol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| OMNIPAQUE 180 | GE Healthcare | N-018956 RX | 1985-12-26 | 1 products, RLD, RS |
| OMNIPAQUE 240 | GE Healthcare | N-018956 RX | 1985-12-26 | 1 products, RLD, RS |
| OMNIPAQUE 300 | GE Healthcare | N-018956 RX | 1985-12-26 | 1 products, RLD, RS |
| OMNIPAQUE 350 | GE Healthcare | N-018956 RX | 1985-12-26 | 1 products, RLD, RS |
| OMNIPAQUE 140 | GE Healthcare | N-018956 RX | 1988-11-30 | 1 products, RLD, RS |
| OMNIPAQUE 9 | GE Healthcare | N-018956 RX | 2018-04-17 | 1 products, RLD, RS |
| OMNIPAQUE 12 | GE Healthcare | N-018956 RX | 2018-04-17 | 1 products, RLD, RS |
| OMNIPAQUE 300 | GE Healthcare | N-020608 RX | 1995-10-24 | 1 products |
| OMNIPAQUE 350 | GE Healthcare | N-020608 RX | 1995-10-24 | 1 products |
Show 4 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| bl-contrast | unapproved drug other | 2024-08-01 |
| omnipaque | New Drug Application | 2024-10-18 |
| oraltag | New Drug Application | 2023-01-05 |
Indications
FDA
EMA
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Agency Specific
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Clinical
Clinical Trials
149 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | 2 | 2 | 1 | 7 | 13 |
| Healthy volunteers/patients | — | — | — | 7 | — | — | 1 | 1 | 9 |
| Heart failure | D006333 | HP_0001635 | I50 | — | 1 | — | 2 | 3 | 6 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 2 | 2 | — | 1 | 1 | 4 |
| Hiv | D006678 | — | — | — | — | — | 2 | 1 | 3 |
| Coronary artery disease | D003324 | — | I25.1 | — | — | 1 | 1 | 1 | 3 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | — | — | 1 | — | 2 |
| Hormone replacement therapy | D020249 | EFO_0003961 | — | — | — | — | 1 | 1 | 2 |
| Transgenes | D019076 | — | — | — | — | — | 1 | — | 1 |
| Fibrosis | D005355 | — | — | — | — | — | 1 | — | 1 |
Show 8 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Kidney diseases | D007674 | EFO_0003086 | N08 | 3 | 2 | 1 | — | 16 | 20 |
| Acute kidney injury | D058186 | HP_0001919 | N17 | 2 | 1 | 3 | — | 8 | 14 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | 1 | — | 1 | — | 1 | 3 |
| Hyperlipidemias | D006949 | HP_0003077 | E78.5 | — | — | 1 | — | 1 | 2 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | 1 | — | 1 | 2 |
| Colonic polyps | D003111 | — | K63.5 | — | 1 | 1 | — | 1 | 2 |
| Polyps | D011127 | EFO_0000662 | — | — | 1 | 1 | — | 1 | 2 |
| Shock | D012769 | — | R57.1 | — | — | 1 | — | — | 1 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 4 | 3 | — | — | 5 | 9 |
| Diabetic nephropathies | D003928 | EFO_0000401 | — | 3 | 2 | — | — | 4 | 7 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 2 | 1 | — | — | 3 | 5 |
| Diabetes complications | D048909 | — | — | 2 | 2 | — | — | 2 | 4 |
| Insulin resistance | D007333 | HP_0000855 | — | 2 | 1 | — | — | 2 | 4 |
| Pediatric obesity | D063766 | — | — | 2 | 2 | — | — | 2 | 4 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 2 | 2 | — | — | 2 | 4 |
| Nephritis | D009393 | — | N05 | 3 | 3 | — | — | 1 | 4 |
| Spinal stenosis | D013130 | EFO_0007490 | M48.0 | 1 | 1 | — | — | 2 | 3 |
| Pathologic constriction | D003251 | — | — | 1 | 1 | — | — | 1 | 2 |
Show 5 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 3 | — | — | — | 3 | 6 |
| Intervertebral disc displacement | D007405 | EFO_1001800 | — | 1 | — | — | — | 3 | 4 |
| Triple negative breast neoplasms | D064726 | — | — | 2 | — | — | — | — | 2 |
| Pelvic neoplasms | D010386 | — | — | 1 | — | — | — | 1 | 2 |
| Glomerular filtration rate | D005919 | EFO_0005208 | — | 2 | — | — | — | — | 2 |
| Leiomyoma | D007889 | HP_0000131 | D25 | 1 | — | — | — | — | 1 |
| Adenomyosis | D062788 | EFO_1001757 | N80.0 | 1 | — | — | — | — | 1 |
| Drug interactions | D004347 | — | — | 1 | — | — | — | — | 1 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 1 | — | — | — | — | 1 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 1 | — | — | — | — | 1 |
Show 6 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic renal insufficiency | D051436 | — | N18 | — | — | — | — | 8 | 8 |
| Low back pain | D017116 | HP_0003419 | M54.5 | — | — | — | — | 4 | 4 |
| Critical illness | D016638 | — | — | — | — | — | — | 3 | 3 |
| Retinal diseases | D012164 | HP_0000479 | H35.9 | — | — | — | — | 3 | 3 |
| Failed back surgery syndrome | D055111 | — | — | — | — | — | — | 3 | 3 |
| Radiculopathy | D011843 | — | M54.1 | — | — | — | — | 3 | 3 |
| Syndrome | D013577 | — | — | — | — | — | — | 3 | 3 |
| Back pain | D001416 | HP_0003418 | M54 | — | — | — | — | 2 | 2 |
| Colorectal neoplasms | D015179 | — | — | — | — | — | — | 2 | 2 |
| Deglutition disorders | D003680 | HP_0002015 | R13.1 | — | — | — | — | 2 | 2 |
Show 104 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Iohexol |
| INN | iohexol |
| Description | Iohexol is a benzenedicarboxamide compound having N-(2,3-dihydroxypropyl)carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an N-(2,3-dihydroxypropyl)acetamido group at the 5-position. It has a role as a radioopaque medium, an environmental contaminant and a xenobiotic. It is an organoiodine compound and a benzenedicarboxamide. |
| Classification | Small molecule |
| Drug class | iodine-containing contrast media |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(=O)N(CC(O)CO)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I |
Identifiers
| PDB | — |
| CAS-ID | 66108-95-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200455 |
| ChEBI ID | 31709 |
| PubChem CID | 3730 |
| DrugBank | DB01362 |
| UNII ID | 4419T9MX03 (ChemIDplus, GSRS) |
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Financial
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Trends
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Safety
Black-box Warning
Black-box warning for: Bl-contrast, Omnipaque
Adverse Events
Top Adverse Reactions
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7,045 adverse events reported
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