Iodixanol
Iodixanol, Visipaque (iodixanol) is an unknown pharmaceutical. Iodixanol was first approved as Visipaque 270 on 1996-03-22.
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Events Timeline
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
Iodixanol, Visipaque (discontinued: Visipaque)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Iodixanol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VISIPAQUE 270 | GE Healthcare | N-020351 RX | 1996-03-22 | 1 products, RLD, RS |
| VISIPAQUE 320 | GE Healthcare | N-020351 RX | 1996-03-22 | 1 products, RLD, RS |
| VISIPAQUE 320 | GE Healthcare | N-020808 RX | 1997-08-29 | 1 products |
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Indications
FDA
EMA
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Agency Specific
FDA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
67 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronary artery disease | D003324 | — | I25.1 | — | — | 2 | 6 | 5 | 13 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | — | 1 | 10 | 1 | 12 |
| Chronic renal insufficiency | D051436 | — | N18 | — | — | — | 6 | 2 | 8 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | 1 | 4 | 3 | 8 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | — | 2 | 2 | 4 |
| Pulmonary embolism | D011655 | HP_0002204 | I26 | — | — | — | 2 | 2 | 4 |
| Embolism | D004617 | — | — | — | — | — | 2 | 2 | 4 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | — | 1 | 2 | 3 |
| Infarction | D007238 | EFO_0009463 | — | — | — | — | 1 | 2 | 3 |
| Healthy volunteers/patients | — | — | — | 2 | 1 | — | 1 | — | 3 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acute kidney injury | D058186 | HP_0001919 | N17 | 1 | — | 1 | — | 1 | 3 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | 1 | — | — | 1 |
| Hyperlipidemias | D006949 | HP_0003077 | E78.5 | — | — | 1 | — | — | 1 |
| Ischemic stroke | D000083242 | — | — | — | — | 1 | — | — | 1 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | 1 | — | — | 1 |
| Carotid stenosis | D016893 | — | — | — | — | 1 | — | — | 1 |
| Computed tomography angiography | D000072226 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | — | — | — | 2 | 2 |
| Cardio-renal syndrome | D059347 | — | — | — | — | — | — | 2 | 2 |
| Pathologic constriction | D003251 | — | — | — | — | — | — | 2 | 2 |
| Glioblastoma | D005909 | EFO_0000515 | — | — | — | — | — | 1 | 1 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 1 | 1 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | — | — | — | 1 | 1 |
| Small cell lung carcinoma | D055752 | — | — | — | — | — | — | 1 | 1 |
| Mesothelioma | D008654 | — | C45 | — | — | — | — | 1 | 1 |
| Pancreatitis | D010195 | HP_0001733 | K85 | — | — | — | — | 1 | 1 |
| St elevation myocardial infarction | D000072657 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Iodixanol |
| INN | iodixanol |
| Description | Iodixanol is a dimeric, non-ionic, water-soluble, radiographic contrast agent, used particularly in coronary angiography. It has a role as a radioopaque medium. |
| Classification | Small molecule |
| Drug class | iodine-containing contrast media |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(=O)N(CC(O)CN(C(C)=O)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I |
Identifiers
| PDB | — |
| CAS-ID | 92339-11-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200507 |
| ChEBI ID | 31705 |
| PubChem CID | 3724 |
| DrugBank | DB01249 |
| UNII ID | HW8W27HTXX (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Safety
Black-box Warning
Black-box warning for: Iodixanol, Visipaque
Adverse Events
Top Adverse Reactions
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2,837 adverse events reported
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