Intermedine
Intermedine is a protein pharmaceutical. It is currently being investigated in clinical studies. It is known to target calcitonin receptor and calcitonin gene-related peptide type 1 receptor.
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
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Commercial
No data
Clinical
Clinical Trials
204 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | 1 | 2 | 3 | — | 5 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 1 | — | 1 | 2 | 4 |
| Sarcoidosis | D012507 | EFO_0000690 | D80-D89 | — | — | — | 3 | 1 | 4 |
| Proteinuria | D011507 | — | R80 | — | 1 | 1 | 2 | — | 4 |
| Nephrotic syndrome | D009404 | EFO_0004255 | N04 | — | 1 | 1 | 2 | — | 4 |
| Sclerosis | D012598 | — | — | — | 1 | 2 | 1 | — | 3 |
| Intermediate uveitis | D015867 | EFO_1000986 | — | — | 1 | — | 2 | — | 3 |
| Posterior uveitis | D015866 | EFO_1001119 | — | — | 1 | — | 2 | — | 3 |
| Uveitis | D014605 | EFO_1001231 | H20.9 | — | 1 | — | 2 | — | 3 |
| Membranous glomerulonephritis | D015433 | EFO_0004254 | N03.2 | 1 | — | — | 1 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | — | 2 | 1 | — | — | 2 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 1 | 1 | — | — | 2 |
| Recurrence | D012008 | — | — | — | 1 | 1 | — | — | 1 |
| Syndrome | D013577 | — | — | — | — | 1 | — | — | 1 |
| Nephrosis | D009401 | — | — | — | — | 1 | — | — | 1 |
| Fatigue | D005221 | — | R53.83 | — | — | 1 | — | — | 1 |
| Relapsing-remitting multiple sclerosis | D020529 | EFO_0003929 | — | — | — | 1 | — | — | 1 |
| Iga glomerulonephritis | D005922 | EFO_0004194 | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Duchenne muscular dystrophy | D020388 | EFO_0000429 | — | — | 1 | — | — | — | 1 |
| Muscular dystrophies | D009136 | EFO_0000757 | G71.0 | — | 1 | — | — | — | 1 |
| Dermatomyositis | D003882 | EFO_0000398 | M33 | — | 1 | — | — | — | 1 |
| Polymyositis | D017285 | EFO_0003063 | M33.2 | — | 1 | — | — | — | 1 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | 1 | — | — | — | 1 |
| Chronic progressive multiple sclerosis | D020528 | EFO_0003840 | — | — | 1 | — | — | — | 1 |
| Glomerulonephritis | D005921 | — | N05 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Proliferative vitreoretinopathy | D018630 | EFO_1001129 | — | 1 | — | — | — | — | 1 |
| Neuritis | D009443 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | — | — | — | 2 | 2 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Intermedine |
| INN | intermedine |
| Description | INTERMEDINE |
| Classification | Protein |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C |
Identifiers
| PDB | — |
| CAS-ID | 581-05-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL214332 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | OVF025LA77 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CALCRL
CALCRL
Organism
Homo sapiens
Gene name
CALCRL
Gene synonyms
CGRPR
NCBI Gene ID
Protein name
calcitonin gene-related peptide type 1 receptor
Protein synonyms
calcitonin receptor-like, Calcitonin receptor-like receptor, CGRP type 1 receptor
Uniprot ID
Mouse ortholog
Calcrl (54598)
calcitonin gene-related peptide type 1 receptor (Q9WUP2)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 22,582 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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10 adverse events reported
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