Intermedine
Intermedine is a protein pharmaceutical. It is currently being investigated in clinical studies. It is known to target calcitonin receptor and calcitonin gene-related peptide type 1 receptor.
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Commercial
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Clinical
Clinical Trials
173 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syndrome | D013577 | — | — | — | 2 | 5 | 3 | 5 | 15 |
| Sclerosis | D012598 | — | — | — | 4 | 4 | 4 | 2 | 12 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | — | 1 | 1 | 7 | 2 | 11 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | 2 | 3 | 5 | 2 | 11 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 1 | 1 | 5 | 2 | 9 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 3 | 1 | 4 | 1 | 9 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | 1 | 4 | 7 |
| Proteinuria | D011507 | HP_0000093 | R80 | — | 1 | — | 5 | 1 | 7 |
| Nephrotic syndrome | D009404 | EFO_0004255 | N04 | — | — | 2 | 5 | — | 7 |
| Sarcoidosis | D012507 | EFO_0000690 | D80-D89 | — | 2 | 2 | 3 | 2 | 7 |
Show 32 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pituitary acth hypersecretion | D047748 | EFO_1001110 | E24.0 | — | 4 | 5 | — | 3 | 12 |
| Cushing syndrome | D003480 | EFO_0003099 | E24 | — | 1 | 4 | — | 4 | 9 |
| Acth-secreting pituitary adenoma | D049913 | — | — | — | 4 | 2 | — | 1 | 7 |
| Adrenocortical hyperfunction | D000308 | EFO_1000797 | — | — | 2 | 1 | — | 3 | 6 |
| Adrenocortical adenoma | D018246 | — | — | — | — | 1 | — | 2 | 3 |
| Hyperaldosteronism | D006929 | HP_0011736 | E26 | — | — | 1 | — | 2 | 3 |
| Fatigue | D005221 | HP_0012378 | R53.83 | — | — | 1 | — | 2 | 3 |
| Inflammation | D007249 | MP_0001845 | — | 1 | — | 1 | — | — | 2 |
| Adenoma | D000236 | — | — | — | — | 1 | — | 1 | 2 |
| Amyotrophic lateral sclerosis | D000690 | HP_0007354 | G12.21 | — | 2 | 1 | — | — | 2 |
Show 8 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | — | 1 | — | — | 1 | 2 |
| Infantile spasms | D013036 | HP_0011097 | G40.82 | — | 1 | — | — | 1 | 2 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | 1 | — | — | — | 1 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 1 | — | — | — | 1 |
| Polymyositis | D017285 | EFO_0003063 | M33.2 | — | 1 | — | — | — | 1 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | 1 | — | — | — | 1 |
| Spasm | D013035 | — | M62.83 | — | 1 | — | — | — | 1 |
| Polyneuropathies | D011115 | EFO_0009562 | A69.22 | — | 1 | — | — | — | 1 |
| Chronic inflammatory demyelinating polyradiculoneuropathy | D020277 | EFO_1000868 | G61.81 | — | 1 | — | — | — | 1 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | 1 | — | — | — | 1 |
Show 8 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Adrenal insufficiency | D000309 | — | — | 2 | — | — | — | 6 | 8 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | 1 | 2 |
| Newborn infant diseases | D007232 | — | — | 1 | — | — | — | — | 1 |
| Adrenal cortex diseases | D000303 | — | — | 1 | — | — | — | — | 1 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.9 | 1 | — | — | — | — | 1 |
| Cannabis | D002188 | — | — | 1 | — | — | — | — | 1 |
| Smoking | D012907 | EFO_0004318 | — | 1 | — | — | — | — | 1 |
| Metabolic bone diseases | D001851 | HP_0000938 | — | 1 | — | — | — | — | 1 |
| Osteoporosis | D010024 | HP_0000939 | M81.0 | 1 | — | — | — | — | 1 |
| Proliferative vitreoretinopathy | D018630 | EFO_1001129 | — | 1 | — | — | — | — | 1 |
Show 4 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | — | — | 3 | 3 |
| Lung diseases | D008171 | HP_0002088 | J98.4 | — | — | — | — | 3 | 3 |
| Obstructive lung diseases | D008173 | HP_0006536 | — | — | — | — | — | 3 | 3 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 3 | 3 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 3 | 3 |
| Brain injuries | D001930 | — | S06.9 | — | — | — | — | 2 | 2 |
| Addison disease | D000224 | — | E27.1 | — | — | — | — | 2 | 2 |
| Depression | D003863 | — | F33.9 | — | — | — | — | 2 | 2 |
| Cataract | D002386 | HP_0000518 | H26.9 | — | — | — | — | 2 | 2 |
| Breast feeding | D001942 | — | — | — | — | — | — | 2 | 2 |
Show 72 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Intermedine |
| INN | intermedine |
| Description | INTERMEDINE |
| Classification | Protein |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C |
Identifiers
| PDB | — |
| CAS-ID | 581-05-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL214332 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | OVF025LA77 (ChemIDplus, GSRS) |
Target
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Trends
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Safety
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Adverse Events
0 adverse events reported
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