Intermedine
Intermedine is a protein pharmaceutical. It is currently being investigated in clinical studies. It is known to target calcitonin receptor and calcitonin gene-related peptide type 1 receptor.
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Commercial
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Clinical
Clinical Trials
216 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 1 | 2 | 3 | 5 | 3 | 13 |
| Adrenal insufficiency | D000309 | — | — | 2 | — | 1 | 2 | 7 | 12 |
| Sarcoidosis | D012507 | EFO_0000690 | D80-D89 | — | 2 | 2 | 3 | 3 | 8 |
| Pelvic organ prolapse | D056887 | EFO_0004710 | — | — | — | — | 1 | 7 | 8 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 1 | — | 4 | 2 | 7 |
| Proteinuria | D011507 | — | R80 | — | 1 | 1 | 2 | 3 | 7 |
| Incisional hernia | D000069290 | — | K43.2 | — | — | 1 | 1 | 5 | 7 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 3 | 1 | 1 | 2 | 7 |
| Sclerosis | D012598 | — | — | — | 1 | 2 | 2 | 2 | 6 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | 2 | 2 | 5 |
Show 34 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pituitary acth hypersecretion | D047748 | EFO_1001110 | E24.0 | 1 | 4 | 5 | — | 3 | 13 |
| Cushing syndrome | D003480 | EFO_0003099 | E24 | — | 2 | 4 | — | 5 | 11 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | 1 | 2 | — | 2 | 6 |
| Ectopic acth syndrome | D000182 | EFO_1001256 | E24.3 | — | 1 | 4 | — | 1 | 6 |
| Pituitary diseases | D010900 | — | E23.7 | — | 1 | 2 | — | 2 | 5 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | 3 | — | 1 | 4 |
| Pituitary neoplasms | D010911 | — | — | 1 | 1 | 1 | — | — | 3 |
| Syndrome | D013577 | — | — | — | — | 2 | — | 1 | 3 |
| Relapsing-remitting multiple sclerosis | D020529 | EFO_0003929 | — | — | — | 2 | — | 1 | 3 |
| Adrenal cortex neoplasms | D000306 | — | C74.0 | — | — | 2 | — | 1 | 3 |
Show 32 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | 1 | — | — | 1 | 3 |
| Headache | D006261 | — | R51 | — | 2 | — | — | — | 2 |
| Duchenne muscular dystrophy | D020388 | EFO_0000429 | — | — | 1 | — | — | 1 | 2 |
| Dermatomyositis | D003882 | EFO_0000398 | M33 | — | 1 | — | — | 1 | 2 |
| Polymyositis | D017285 | EFO_0003063 | M33.2 | — | 1 | — | — | 1 | 2 |
| Prostatic neoplasms | D011471 | — | C61 | — | 1 | — | — | 1 | 2 |
| Congenital adrenal hyperplasia | D000312 | — | E25.0 | — | 2 | — | — | — | 2 |
| Adrenocortical hyperfunction | D000308 | EFO_1000797 | — | — | 1 | — | — | — | 1 |
| Acth-secreting pituitary adenoma | D049913 | — | — | — | 1 | — | — | — | 1 |
| Colorectal neoplasms | D015179 | — | — | — | 1 | — | — | — | 1 |
Show 8 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | 2 | — | — | — | 2 | 4 |
| Hyperandrogenism | D017588 | — | — | 1 | — | — | — | 1 | 2 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 1 | — | — | — | — | 1 |
| Diabetic ketoacidosis | D016883 | EFO_1000897 | — | 1 | — | — | — | — | 1 |
| Newborn infant diseases | D007232 | — | — | 1 | — | — | — | — | 1 |
| Adrenal cortex diseases | D000303 | — | — | 1 | — | — | — | — | 1 |
| Marijuana abuse | D002189 | EFO_0007191 | F12 | 1 | — | — | — | — | 1 |
| Cannabis | D002188 | — | — | 1 | — | — | — | — | 1 |
| Smoking | D012907 | EFO_0004318 | — | 1 | — | — | — | — | 1 |
| Metabolic bone diseases | D001851 | — | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ventral hernia | D006555 | EFO_1001866 | K43 | — | — | — | — | 4 | 4 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | — | — | 3 | 3 |
| Lung diseases | D008171 | EFO_0003818 | J98.4 | — | — | — | — | 3 | 3 |
| Obstructive lung diseases | D008173 | — | — | — | — | — | — | 3 | 3 |
| Uterine prolapse | D014596 | EFO_1001864 | N81.4 | — | — | — | — | 3 | 3 |
| Back pain | D001416 | — | M54 | — | — | — | — | 2 | 2 |
| Gout | D006073 | EFO_0004274 | M10 | — | — | — | — | 2 | 2 |
| Brain injuries | D001930 | — | S06.9 | — | — | — | — | 2 | 2 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | — | — | — | 2 | 2 |
| Adrenal gland neoplasms | D000310 | EFO_0003850 | C74 | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Intermedine |
| INN | intermedine |
| Description | INTERMEDINE |
| Classification | Protein |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C |
Identifiers
| PDB | — |
| CAS-ID | 581-05-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL214332 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | OVF025LA77 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CALCRL
CALCRL
Organism
Homo sapiens
Gene name
CALCRL
Gene synonyms
CGRPR
NCBI Gene ID
Protein name
calcitonin gene-related peptide type 1 receptor
Protein synonyms
calcitonin receptor-like, Calcitonin receptor-like receptor, CGRP type 1 receptor
Uniprot ID
Mouse ortholog
Calcrl (54598)
calcitonin gene-related peptide type 1 receptor (Q9WUP2)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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10 adverse events reported
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