Inositol
Inositol is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target anoctamin-1, two pore channel protein 1, inositol polyphosphate-5-phosphatase A, inositol 1,4,5-trisphosphate-gated calcium channel ITPR1, mucolipin-2, inositol 1,4,5-trisphosphate-gated calcium channel ITPR2, inositol 1,4,5-trisphosphate-gated calcium channel ITPR3, mucolipin-3, two pore channel protein 2, and mucolipin-1.
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Commercial
Therapeutic Areas
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Trade Name
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
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Labels
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Agency Specific
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ATC Codes
A: Alimentary tract and metabolism drugs
— A11: Vitamins
— A11H: Other plain vitamin preparations in atc
— A11HA: Other plain vitamin preparations in atc
— A11HA07: Inositol
C: Cardiovascular system drugs
— C04: Peripheral vasodilators
— C04A: Peripheral vasodilators
— C04AC: Nicotinic acid and derivatives, peripheral vasodilators
— C04AC03: Inositol nicotinate
HCPCS
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Clinical
Clinical Trials
163 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | — | — | — | 1 | — | 1 |
| Ovulation induction | D010062 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Inositol |
| INN | inositol |
| Description | Myo-inositol is an inositol having myo- configuration. It has a role as a member of compatible osmolytes, a nutrient, an EC 3.1.4.11 (phosphoinositide phospholipase C) inhibitor, a human metabolite, a Daphnia magna metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 87-89-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1222251 |
| ChEBI ID | 17268 |
| PubChem CID | 892 |
| DrugBank | DB03106 |
| UNII ID | 4L6452S749 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
ITPR1
ITPR1
Organism
Homo sapiens
Gene name
ITPR1
Gene synonyms
INSP3R1
NCBI Gene ID
Protein name
inositol 1,4,5-trisphosphate receptor type 1
Protein synonyms
inositol 1,4,5-triphosphate receptor, type 1, InsP3R1, IP3 receptor, IP3 receptor isoform 1, IP3R 1, protein phosphatase 1, regulatory subunit 94, Type 1 inositol 1,4,5-trisphosphate receptor, Type 1 InsP3 receptor
Uniprot ID
Mouse ortholog
Itpr1 (16438)
inositol 1,4,5-trisphosphate receptor type 1 (Q99LG5)
Variants
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Financial
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Estimated US medical usage
Inositol
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Additional graphs summarizing 38,002 documents
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Safety
Black-box Warning
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Adverse Events
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129 adverse events reported
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