Inositol
Inositol is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target anoctamin-1, two pore channel protein 1, inositol polyphosphate-5-phosphatase A, inositol 1,4,5-trisphosphate-gated calcium channel ITPR1, mucolipin-2, inositol 1,4,5-trisphosphate-gated calcium channel ITPR2, inositol 1,4,5-trisphosphate-gated calcium channel ITPR3, mucolipin-3, two pore channel protein 2, and mucolipin-1.
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Drug Products
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
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Agency Specific
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ATC Codes
A: Alimentary tract and metabolism drugs
— A11: Vitamins
— A11H: Other plain vitamin preparations in atc
— A11HA: Other plain vitamin preparations in atc
— A11HA07: Inositol
C: Cardiovascular system drugs
— C04: Peripheral vasodilators
— C04A: Peripheral vasodilators
— C04AC: Nicotinic acid and derivatives, peripheral vasodilators
— C04AC03: Inositol nicotinate
HCPCS
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Clinical
Clinical Trials
164 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | 1 | 6 | 4 | 5 | 25 | 39 |
| Syndrome | D013577 | — | — | 1 | 5 | 3 | 4 | 22 | 34 |
| Infertility | D007246 | EFO_0000545 | — | — | 2 | 2 | 3 | 12 | 18 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | — | 2 | — | 3 | 7 | 12 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 2 | 5 | 1 | 6 | 12 |
| Gestational diabetes | D016640 | — | O24.4 | — | — | — | 1 | 10 | 11 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | 1 | — | 1 | 6 | 8 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 2 | 4 | 1 | 2 | 7 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 4 | — | 1 | — | 5 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | 2 | 2 | — | 1 | 1 | 5 |
Show 12 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Female infertility | D007247 | EFO_0008560 | N97 | — | — | 1 | — | 5 | 6 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | 2 | 1 | — | 1 | 4 |
| Retinopathy of prematurity | D012178 | EFO_1001158 | H35.1 | — | 2 | 1 | — | — | 3 |
| Leiomyoma | D007889 | — | D25 | — | — | 1 | — | 2 | 3 |
| Myofibroma | D047708 | — | — | — | — | 1 | — | 2 | 3 |
| Overweight | D050177 | — | E66.3 | — | — | 1 | — | 1 | 2 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | — | 1 | — | — | 1 |
| Retinal diseases | D012164 | — | H35.9 | — | — | 1 | — | — | 1 |
| Hypoglycemia | D007003 | — | E16.2 | — | — | 1 | — | — | 1 |
| Aortic valve stenosis | D001024 | EFO_0000266 | — | — | 1 | 1 | — | — | 1 |
Show 3 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | 1 | — | — | 2 | 3 |
| Hyperandrogenism | D017588 | — | — | — | 1 | — | — | 1 | 2 |
| Psychomotor agitation | D011595 | — | — | — | 2 | — | — | — | 2 |
| Aggression | D000374 | EFO_0003015 | — | — | 2 | — | — | — | 2 |
| Bronchopulmonary dysplasia | D001997 | — | P27.8 | — | 2 | — | — | — | 2 |
| Birth weight | D001724 | EFO_0004344 | — | — | 2 | — | — | — | 2 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | 1 | — | — | — | 2 |
| Anovulation | D000858 | — | — | — | 1 | — | — | — | 1 |
| Chronic periodontitis | D055113 | EFO_0006343 | K05.3 | — | 1 | — | — | — | 1 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | 1 | — | — | — | 1 |
Show 22 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | 2 | — | — | — | 2 | 4 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 1 | — | — | — | 2 | 3 |
| Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | 2 | — | — | — | — | 2 |
| Neural tube defects | D009436 | — | Q00.0 | 1 | — | — | — | 1 | 2 |
| Spinal dysraphism | D016135 | EFO_1001210 | Q05 | 1 | — | — | — | 1 | 2 |
| Precancerous conditions | D011230 | — | — | 1 | — | — | — | — | 1 |
| Treatment-resistant depressive disorder | D061218 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Male infertility | D007248 | EFO_0004248 | N46 | — | — | — | — | 3 | 3 |
| Menstruation disturbances | D008599 | — | N91.5 | — | — | — | — | 3 | 3 |
| Marfan syndrome | D008382 | Orphanet_558 | Q87.4 | — | — | — | — | 3 | 3 |
| Healthy volunteers/patients | — | — | — | — | — | — | — | 2 | 2 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 2 | 2 |
| Asthenozoospermia | D053627 | — | — | — | — | — | — | 2 | 2 |
| Hirsutism | D006628 | — | L68.0 | — | — | — | — | 2 | 2 |
| Hypercholesterolemia | D006937 | — | — | — | — | — | — | 2 | 2 |
| Fibrosis | D005355 | — | — | — | — | — | — | 2 | 2 |
| Pregnancy rate | D018873 | — | — | — | — | — | — | 2 | 2 |
Show 69 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Inositol |
| INN | inositol |
| Description | Myo-inositol is an inositol having myo- configuration. It has a role as a member of compatible osmolytes, a nutrient, an EC 3.1.4.11 (phosphoinositide phospholipase C) inhibitor, a human metabolite, a Daphnia magna metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 87-89-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1222251 |
| ChEBI ID | 17268 |
| PubChem CID | 892 |
| DrugBank | DB03106 |
| UNII ID | 4L6452S749 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
ITPR1
ITPR1
Organism
Homo sapiens
Gene name
ITPR1
Gene synonyms
INSP3R1
NCBI Gene ID
Protein name
inositol 1,4,5-trisphosphate receptor type 1
Protein synonyms
inositol 1,4,5-triphosphate receptor, type 1, InsP3R1, IP3 receptor, IP3 receptor isoform 1, IP3R 1, protein phosphatase 1, regulatory subunit 94, Type 1 inositol 1,4,5-trisphosphate receptor, Type 1 InsP3 receptor
Uniprot ID
Mouse ortholog
Itpr1 (16438)
inositol 1,4,5-trisphosphate receptor type 1 (Q99LG5)
Variants
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Financial
Revenue by drug
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Estimated US medical usage
Inositol
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Safety
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Adverse Events
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129 adverse events reported
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