Inamrinone
Amrinone (inamrinone) is a small molecule pharmaceutical. Inamrinone was first approved as Inocor on 1984-07-31. It is used to treat cardiogenic shock, dilated cardiomyopathy, heart failure, and low cardiac output in the USA. The pharmaceutical is active against cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A and cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Amrinone (discontinued: Amrinone, Inocor)
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Drug
General
| Drug common name | Inamrinone |
| INN | amrinone |
| Description | Amrinone is a 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure. It has a role as an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor. |
| Classification | Small molecule |
| Drug class | cardiotonics (amrinone type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1cc(-c2ccncc2)c[nH]c1=O |
Identifiers
| PDB | — |
| CAS-ID | 60719-84-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL12856 |
| ChEBI ID | — |
| PubChem CID | 3698 |
| DrugBank | DB01427 |
| UNII ID | JUT23379TN (ChemIDplus, GSRS) |
Target
Agency Approved
PDE3A
PDE3A
PDE3B
PDE3B
Organism
Homo sapiens
Gene name
PDE3A
Gene synonyms
NCBI Gene ID
Protein name
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
Protein synonyms
cAMP phosphodiesterase, myocardial cGMP-inhibited, cGI-PDE, CGI-PDE A, cGMP-inhibited 3',5'-cyclic phosphodiesterase A, cGMP-inhibited cAMP phosphodiesterase, Cyclic GMP-inhibited phosphodiesterase A, phosphodiesterase 3A, cGMP-inhibited
Uniprot ID
Mouse ortholog
Pde3a (54611)
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Q9Z0X4)
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2,043 adverse events reported
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