Inamrinone
Amrinone (inamrinone) is a small molecule pharmaceutical. Inamrinone was first approved as Inocor on 1984-07-31. It is used to treat cardiogenic shock, dilated cardiomyopathy, heart failure, and low cardiac output in the USA. The pharmaceutical is active against cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A and cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Amrinone (discontinued: Amrinone, Inocor)
Labels
FDA
EMA
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Indications
FDA
EMA
Agency Specific
FDA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
49 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | 2 | 4 | 2 | 1 | 1 | 8 |
| Low cardiac output | D002303 | — | — | 1 | 2 | 2 | 1 | 2 | 7 |
| Cardiogenic shock | D012770 | — | R57.0 | 1 | — | — | 2 | — | 3 |
| Septic shock | D012772 | — | A48.3 | — | 1 | — | 1 | — | 2 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | — | 1 | — | 1 |
| Pulmonary edema | D011654 | EFO_1001134 | J81 | — | — | — | 1 | — | 1 |
| Hemodynamics | D006439 | — | — | — | — | — | 1 | — | 1 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | — | — | — | 1 | — | 1 |
| Anesthesia | D000758 | — | — | — | — | — | 1 | — | 1 |
| Shock | D012769 | — | R57.1 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal insufficiency | D051437 | — | N19 | — | 1 | 1 | — | — | 2 |
| Intracranial vasospasm | D020301 | EFO_1000994 | G45.9 | — | 1 | 1 | — | — | 2 |
| Spasm | D013035 | — | M62.83 | — | 1 | 1 | — | — | 2 |
| Cardiac surgical procedures | D006348 | — | — | — | — | 1 | — | — | 1 |
| Mitral valve insufficiency | D008944 | — | — | — | — | 1 | — | — | 1 |
| Aneurysm | D000783 | — | I72.9 | — | — | 1 | — | — | 1 |
| Vasodilation | D014664 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | EFO_0003144 | I50 | 3 | 4 | — | — | 2 | 7 |
| Congenital heart defects | D006330 | — | Q24.9 | 1 | 4 | — | — | 1 | 5 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | 2 | — | — | 1 | 3 |
| Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | — | 3 | — | — | — | 3 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | 1 | — | — | 2 | 3 |
| Persistent fetal circulation syndrome | D010547 | EFO_1001103 | P29.3 | — | 1 | — | — | 2 | 3 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | 1 | — | — | 1 | 2 |
| Right ventricular dysfunction | D018497 | — | — | 1 | 1 | — | — | — | 2 |
| Ischemia | D007511 | EFO_0000556 | — | — | 1 | — | — | — | 1 |
| Cerebral infarction | D002544 | — | I63 | — | 1 | — | — | — | 1 |
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiopulmonary bypass | D002315 | — | — | — | — | — | — | 2 | 2 |
| Sprains and strains | D013180 | — | — | — | — | — | — | 2 | 2 |
| Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 1 | 1 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | — | 1 | 1 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | — | — | — | — | 1 | 1 |
| Menorrhagia | D008595 | EFO_0003945 | N92.0 | — | — | — | — | 1 | 1 |
| Hemophilia a | D006467 | EFO_0007267 | D66 | — | — | — | — | 1 | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 1 | 1 |
| Down syndrome | D004314 | EFO_0001064 | Q90 | — | — | — | — | 1 | 1 |
| Pneumonia | D011014 | EFO_0003106 | J18 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Inamrinone |
| INN | amrinone |
| Description | Amrinone is a 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure. It has a role as an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor. |
| Classification | Small molecule |
| Drug class | cardiotonics (amrinone type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1cc(-c2ccncc2)c[nH]c1=O |
Identifiers
| PDB | — |
| CAS-ID | 60719-84-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL12856 |
| ChEBI ID | — |
| PubChem CID | 3698 |
| DrugBank | DB01427 |
| UNII ID | JUT23379TN (ChemIDplus, GSRS) |
Target
Agency Approved
PDE3A
PDE3A
PDE3B
PDE3B
Organism
Homo sapiens
Gene name
PDE3A
Gene synonyms
NCBI Gene ID
Protein name
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
Protein synonyms
cAMP phosphodiesterase, myocardial cGMP-inhibited, cGI-PDE, CGI-PDE A, cGMP-inhibited 3',5'-cyclic phosphodiesterase A, cGMP-inhibited cAMP phosphodiesterase, Cyclic GMP-inhibited phosphodiesterase A, phosphodiesterase 3A, cGMP-inhibited
Uniprot ID
Mouse ortholog
Pde3a (54611)
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Q9Z0X4)
Alternate
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Variants
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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2,101 adverse events reported
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