Imlifidase
Idefirix (imlifidase) is an enzyme pharmaceutical. Imlifidase was first approved as Idefirix on 2020-08-25. It has been approved in Europe to treat immunologic desensitization and kidney transplantation.
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30 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis b | D006509 | — | — | — | 1 | — | 3 | 1 | 5 |
| Chronic hepatitis b | D019694 | EFO_0004239 | B18.1 | — | 2 | 1 | 2 | — | 4 |
| Hepatitis | D006505 | — | K75.9 | — | 2 | 1 | 2 | — | 4 |
| Chronic hepatitis | D006521 | — | K73.9 | — | 1 | — | 1 | — | 2 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Kidney transplantation | D016030 | — | — | — | 3 | 2 | — | 1 | 6 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | 3 | 1 | — | — | 4 |
| Anti-glomerular basement membrane disease | D019867 | EFO_0007290 | M31.0 | — | 1 | 1 | — | — | 2 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 3 | — | — | — | 3 |
| Graft rejection | D006084 | — | — | — | 1 | — | — | 1 | 2 |
| Renal insufficiency | D051437 | — | N19 | — | 1 | — | — | 1 | 2 |
| Guillain-barre syndrome | D020275 | EFO_0007292 | G61.0 | — | 1 | — | — | — | 1 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | — | 1 | — | — | — | 1 |
| Thrombotic thrombocytopenic purpura | D011697 | — | M31.19 | — | 1 | — | — | — | 1 |
| Thrombocytopenic purpura | D011696 | — | — | — | 1 | — | — | — | 1 |
| Purpura | D011693 | HP_0000979 | D69.2 | — | 1 | — | — | — | 1 |
| Retinal diseases | D012164 | — | H35.9 | 1 | 1 | — | — | — | 1 |
| Chronic renal insufficiency | D051436 | — | N18 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
| Duchenne muscular dystrophy | D020388 | EFO_0000429 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Psychology rejection | D012059 | — | — | — | — | — | — | 1 | 1 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 1 | 1 |
| Headache | D006261 | — | R51 | — | — | — | — | 1 | 1 |
| Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Imlifidase |
| INN | imlifidase |
| Description | Imlifidase, brand name Idefirix, is a medication for the desensitization of highly sensitized adults needing kidney transplantation, but unlikely to receive a compatible transplant.
|
| Classification | Enzyme |
| Drug class | enzymes |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 1947415-68-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297981 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB15258 |
| UNII ID | UVJ7NL8S2P (ChemIDplus, GSRS) |
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Safety
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6,754 adverse events reported
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