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AboutPricing
Drug ReportsImipramine
Imipramine
Imipramine (imipramine) is a small molecule pharmaceutical. Imipramine was first approved as Janimine on 1982-01-01. It is used to treat attention deficit disorder with hyperactivity, depressive disorder, enuresis, pain, and panic disorder amongst others in the USA. The pharmaceutical is active against sodium-dependent serotonin transporter and sodium-dependent noradrenaline transporter. In addition, it is known to target G protein-activated inward rectifier potassium channel 2, muscarinic acetylcholine receptor M2, voltage-gated delayed rectifier potassium channel KCNH1; potassium voltage-gated channel subfamily H member 1, and G protein-activated inward rectifier potassium channel 4.
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Financial
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Events Timeline
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3M
6M
YTD
1Y
2Y
5Y
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
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Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
signs and symptoms pathological conditionsD013568
behavior and behavior mechanismsD001520
psychological phenomenaD011579
mental disordersD001523
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
Imipramine, Imipramine pamoate (discontinued: Imipramine, Imipramine pamoate, Janimine, Pramine, Presamine, Tofranil, Tofranil-pm)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Imipramine hydrochloride
Tradename
Company
Number
Date
Products
JANIMINEAbbott BiotherapeuticsN-017895 DISCN1982-01-01
3 products
TOFRANILNovartisN-011838 DISCN1982-01-01
1 products
PRESAMINESanofiN-011836 DISCN1982-01-01
3 products
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Imipramine pamoate
Tradename
Company
Number
Date
Products
TOFRANIL-PMSPECGXN-017090 DISCN1982-01-01
4 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
imipramine hydrochlorideANDA2025-03-28
imipramine pamoateANDA2025-03-18
tofranilANDA2016-12-23
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
painEFO_0003843D010146R52
enuresis—D004775R32
panic disorderEFO_0004262D016584F41.0
psychotic affective disorders—D000341F39
attention deficit disorder with hyperactivityEFO_0003888D001289F90
depressive disorderEFO_1002014D003866F32.A
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N06: Psychoanaleptics
— N06A: Antidepressants
— N06AA: Non-selective monoamine reuptake inhibitors
— N06AA02: Imipramine
— N06AA03: Imipramine oxide
HCPCS
No data
Clinical
Clinical Trials
54 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DepressionD003863—F33.91————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameImipramine
INNimipramine
Description
Imipramine is a dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom. It has a role as an adrenergic uptake inhibitor, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor and an antidepressant. It derives from a hydride of a 5H-dibenzo[b,f]azepine.
Classification
Small molecule
Drug classantidepressants (imipramine type)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN(C)CCCN1c2ccccc2CCc2ccccc21
Identifiers
PDB—
CAS-ID50-49-7
RxCUI—
ChEMBL IDCHEMBL11
ChEBI ID47499
PubChem CID3696
DrugBankDB00458
UNII IDOGG85SX4E4 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
KCNH1
KCNH1
Organism
Homo sapiens
Gene name
KCNH1
Gene synonyms
EAG, EAG1
NCBI Gene ID
3756
Protein name
potassium voltage-gated channel subfamily H member 1
Protein synonyms
EAG channel 1, ether-a-go-go 1, Ether-a-go-go potassium channel 1, ether-a-go-go, Drosophila, homolog of, h-eag, hEAG1, potassium channel, voltage gated eag related subfamily H, member 1, potassium voltage-gated channel, subfamily H (eag-related), member 1, Voltage-gated potassium channel subunit Kv10.1
Uniprot ID
O95259
Mouse ortholog
Kcnh1 (16510)
potassium voltage-gated channel subfamily H member 1 (Q60603)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Imipramine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 19,268 documents
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Safety
Black-box Warning
Black-box warning for: Imipramine hydrochloride, Imipramine pamoate, Tofranil
Adverse Events
Top Adverse Reactions
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8,465 adverse events reported
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