Tradename | Company | Number | Date | Products |
---|---|---|---|---|
PRIMAXIN | Merck KGaA | N-050587 RX | 1985-11-26 | 1 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
RECARBRIO | Merck & Co | N-212819 RX | 2019-07-16 | 1 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
imipenem and cilastatin | ANDA | 2022-10-06 |
imipenem and cilastatin imipenem and cilastatin | ANDA | 2022-10-11 |
primaxin | ANDA, New Drug Application | 2023-12-01 |
recarbrio | New Drug Application | 2023-07-26 |
Expiration | Code | ||
---|---|---|---|
CILASTATIN SODIUM / IMIPENEM / RELEBACTAM, RECARBRIO, MSD MERCK CO | |||
2029-07-16 | GAIN | ||
2024-07-16 | NCE |
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Cilastatin Sodium / Imipenem / Relebactam, Recarbrio, Msd Merck Co | |||
8487093 | 2029-11-19 | DS, DP | U-2586, U-2587, U-2840 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Ventilator-associated pneumonia | D053717 | EFO_1001865 | J95.851 | — | 1 | 4 | 4 | 1 | 10 |
Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | 5 | 3 | 1 | — | 9 |
Critical illness | D016638 | — | — | — | — | 1 | 2 | 4 | 7 |
Sepsis | D018805 | HP_0100806 | A41.9 | 3 | 1 | — | 1 | 3 | 7 |
Pneumonia | D011014 | EFO_0003106 | — | 1 | 1 | — | 2 | 2 | 6 |
Infections | D007239 | EFO_0000544 | — | 1 | — | 1 | 3 | — | 5 |
Bacterial pneumonia | D018410 | EFO_1001272 | J15.9 | — | 2 | 2 | 1 | — | 5 |
Intraabdominal infections | D059413 | — | — | — | 1 | 1 | 1 | — | 3 |
Pancreatitis | D010195 | HP_0001733 | K85 | — | — | — | 1 | 1 | 2 |
Hematologic neoplasms | D019337 | — | — | — | 1 | 1 | 1 | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Bacterial infections | D001424 | — | A49 | 6 | 3 | 2 | — | 3 | 12 |
Enterobacteriaceae infections | D004756 | EFO_1001313 | — | — | — | 1 | — | 1 | 2 |
Iatrogenic disease | D007049 | — | — | — | — | 2 | — | — | 2 |
Bacteremia | D016470 | EFO_0003033 | R78.81 | — | — | 1 | — | 1 | 2 |
Abdominal abscess | D018784 | EFO_1001753 | — | — | 1 | 1 | — | — | 2 |
Lung diseases | D008171 | HP_0002088 | J98.4 | — | 1 | 1 | — | — | 1 |
Cross infection | D003428 | — | — | — | — | 1 | — | — | 1 |
Gram-positive bacterial infections | D016908 | — | — | — | — | 1 | — | — | 1 |
Sinusitis | D012852 | EFO_0007486 | J32 | — | — | 1 | — | — | 1 |
Abscess | D000038 | EFO_0003030 | — | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Pyelonephritis | D011704 | EFO_1001141 | N10-N16 | — | 2 | — | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | — | — | 1 |
Communicable diseases | D003141 | — | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Acute kidney injury | D058186 | HP_0001919 | N17 | — | — | — | — | 2 | 2 |
Inappropriate prescribing | D057970 | — | — | — | — | — | — | 1 | 1 |
Peritonitis | D010538 | EFO_0008588 | K65 | — | — | — | — | 1 | 1 |
Continuous renal replacement therapy | D000079664 | — | — | — | — | — | — | 1 | 1 |
Drug monitoring | D016903 | — | — | — | — | — | — | 1 | 1 |
Neutropenia | D009503 | — | D70 | — | — | — | — | 1 | 1 |
Hematopoietic stem cell transplantation | D018380 | — | — | — | — | — | — | 1 | 1 |
Tuberculosis | D014376 | EFO_0000774 | A15-A19 | — | — | — | — | 1 | 1 |
Septic shock | D012772 | — | A48.3 | — | — | — | — | 1 | 1 |
Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | — | — | 1 | 1 |
Drug common name | Imipenem |
INN | imipenem |
Description | Imipenem is a broad-spectrum, intravenous beta-lactam antibiotic of the carbapenem subgroup. It has a role as an antibacterial drug. It is a beta-lactam antibiotic allergen and a member of carbapenems. It is a tautomer of an imipenem zwitterion. |
Classification | Small molecule |
Drug class | antibacterial antibiotics, carbapenem derivatives |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(SCCNC=N)C[C@H]12 |
PDB | — |
CAS-ID | 64221-86-9 |
RxCUI | — |
ChEMBL ID | CHEMBL148 |
ChEBI ID | 471744 |
PubChem CID | 104838 |
DrugBank | DB01598 |
UNII ID | Q20IM7HE75 (ChemIDplus, GSRS) |