Imetelstat
Imetelstat is an oligonucleotide pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
46 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 3 | 2 | — | — | 5 |
| Primary myelofibrosis | D055728 | — | D47.4 | 1 | 2 | 1 | — | — | 4 |
| Myelodysplastic syndromes | D009190 | — | D46 | — | 2 | 1 | — | 1 | 3 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 9 | 1 | — | — | — | 10 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 4 | 3 | — | — | — | 6 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 4 | 1 | — | — | — | 4 |
| Multiple myeloma | D009101 | — | C90.0 | 2 | 1 | — | — | — | 3 |
| Thyroid neoplasms | D013964 | EFO_0003841 | — | — | 1 | — | — | 1 | 2 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 1 | 1 | — | — | — | 2 |
| Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | — | 1 | — | — | — | 1 |
| Gastrointestinal neoplasms | D005770 | — | C26.9 | — | 1 | — | — | — | 1 |
| Paraneoplastic syndromes | D010257 | — | — | — | 1 | — | — | — | 1 |
| Islet cell adenoma | D007516 | EFO_0007331 | D13.7 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 3 | — | — | — | — | 3 |
| Lymphoproliferative disorders | D008232 | Orphanet_2442 | D47.9 | 2 | — | — | — | — | 2 |
| Colonic neoplasms | D003110 | — | C18 | 1 | — | — | — | — | 1 |
| Rectal neoplasms | D012004 | — | — | 1 | — | — | — | — | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | — | — | — | — | 1 |
| Esophageal neoplasms | D004938 | — | C15 | 1 | — | — | — | — | 1 |
| Central nervous system neoplasms | D016543 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Imetelstat |
| INN | imetelstat |
| Description | Imetelstat (development code GRN163L) is an experimental anticancer drug. The first telomerase inhibitor to enter clinical trials, As of early 2023, it was in Phase 2/3 trials for various cancer types.[which?]
|
| Classification | Oligonucleotide |
| Drug class | enzyme inhibitors: telomerase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 868169-64-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2107856 |
| ChEBI ID | — |
| PubChem CID | 71587831 |
| DrugBank | DB05036 |
| UNII ID | F60NE4XB53 (ChemIDplus, GSRS) |
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Safety
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