Brand Name | Status | Last Update |
---|---|---|
ifex | New Drug Application | 2018-07-26 |
ifosfamide | New Drug Application | 2019-10-30 |
Code | Description |
---|---|
J9208 | Injection, ifosfamide, 1 gram |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Sarcoma | D012509 | — | — | 18 | 54 | 27 | 2 | 13 | 106 |
Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 14 | 26 | 4 | 1 | 1 | 40 |
Non-hodgkin lymphoma | D008228 | — | C85.9 | 5 | 20 | 5 | 2 | 1 | 30 |
Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 4 | 5 | 9 | 5 | 1 | 22 |
Germ cell and embryonal neoplasms | D009373 | — | — | 4 | 14 | 2 | 1 | 1 | 19 |
T-cell lymphoma peripheral | D016411 | — | — | 5 | 4 | 1 | 1 | — | 10 |
Burkitt lymphoma | D002051 | — | C83.7 | 2 | 6 | — | 2 | — | 9 |
Large-cell lymphoma anaplastic | D017728 | — | C84.6 | 4 | 4 | — | 1 | — | 7 |
Enteropathy-associated t-cell lymphoma | D058527 | — | C86.2 | 1 | 1 | — | 1 | — | 3 |
Mediastinal neoplasms | D008479 | — | C38.3 | — | — | 1 | 1 | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Lymphoma | D008223 | — | C85.9 | 10 | 41 | 7 | — | 4 | 56 |
Osteosarcoma | D012516 | — | — | 8 | 18 | 5 | — | 5 | 31 |
Neoplasms | D009369 | — | C80 | 20 | 9 | 3 | — | 2 | 29 |
Hodgkin disease | D006689 | — | C81 | 9 | 16 | 5 | — | 1 | 25 |
Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 8 | 13 | 5 | — | — | 20 |
Leukemia | D007938 | — | C95 | 3 | 10 | 6 | — | 2 | 20 |
Neuroblastoma | D009447 | EFO_0000621 | — | 7 | 7 | 4 | — | 2 | 18 |
Ewing sarcoma | D012512 | EFO_0000173 | — | 3 | 7 | 2 | — | 4 | 16 |
Central nervous system neoplasms | D016543 | — | — | 4 | 8 | 2 | — | — | 11 |
Rhabdomyosarcoma | D012208 | — | — | 3 | 7 | 1 | — | 1 | 10 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 8 | — | — | — | 9 |
Extranodal nk-t-cell lymphoma | D054391 | — | C86.0 | 2 | 6 | — | — | — | 7 |
Urinary bladder neoplasms | D001749 | — | C67 | 1 | 6 | — | — | — | 6 |
B-cell lymphoma | D016393 | — | — | 3 | 3 | — | — | — | 5 |
Mantle-cell lymphoma | D020522 | — | C83.1 | 3 | 3 | — | — | — | 4 |
Testicular neoplasms | D013736 | — | C62 | 2 | 2 | — | — | — | 4 |
T-cell lymphoma | D016399 | — | — | 2 | 3 | — | — | — | 4 |
Desmoplastic small round cell tumor | D058405 | — | — | 1 | 2 | — | — | — | 3 |
Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | 2 | — | — | 1 | 3 |
Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 3 | 2 | — | — | — | 3 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Primitive neuroectodermal tumors | D018242 | — | — | 1 | — | — | — | 2 | 3 |
Wilms tumor | D009396 | EFO_0000212 | — | 2 | — | — | — | 1 | 3 |
Neoplasm metastasis | D009362 | EFO_0009708 | — | 2 | — | — | — | — | 2 |
Retinoblastoma | D012175 | — | — | 1 | — | — | — | 1 | 2 |
Hepatoblastoma | D018197 | — | C22.2 | 1 | — | — | — | 1 | 2 |
Peritoneal neoplasms | D010534 | — | — | 1 | — | — | — | 1 | 2 |
Precursor t-cell lymphoblastic leukemia-lymphoma | D054218 | — | — | 1 | — | — | — | — | 1 |
Mycosis fungoides | D009182 | — | C84.0 | 1 | — | — | — | — | 1 |
Thymoma | D013945 | — | — | 1 | — | — | — | — | 1 |
Thrombocytopenia | D013921 | HP_0001873 | D69.6 | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Nausea | D009325 | HP_0002018 | R11.0 | — | — | — | — | 1 | 1 |
Medulloblastoma | D008527 | — | — | — | — | — | — | 1 | 1 |
Retinal neoplasms | D019572 | — | C69.2 | — | — | — | — | 1 | 1 |
Pituitary neoplasms | D010911 | — | — | — | — | — | — | 1 | 1 |
Pinealoma | D010871 | — | — | — | — | — | — | 1 | 1 |
Sertoli-leydig cell tumor | D018310 | — | — | — | — | — | — | 1 | 1 |
Focal nodular hyperplasia | D020518 | — | — | — | — | — | — | 1 | 1 |
Hamartoma | D006222 | HP_0010566 | — | — | — | — | — | 1 | 1 |
Mesothelioma | D008654 | — | C45 | — | — | — | — | 1 | 1 |
Pseudomyxoma peritonei | D011553 | EFO_0007456 | — | — | — | — | — | 1 | 1 |
Drug common name | Ifosfamide |
INN | ifosfamide |
Description | Ifosfamide is the simplest member of the class of ifosfamides that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by 2-chloroethyl groups on both the nitrogen atoms respectively. It is a nitrogen mustard alkylating agent used in the treatment of advanced breast cancer. It has a role as an antineoplastic agent, an immunosuppressive agent, an alkylating agent, an environmental contaminant and a xenobiotic. |
Classification | Small molecule |
Drug class | phosphoro-derivatives; isophosphoramide mustard derivatives |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | O=P1(NCCCl)OCCCN1CCCl |
PDB | — |
CAS-ID | 3778-73-2 |
RxCUI | — |
ChEMBL ID | CHEMBL1024 |
ChEBI ID | 5864 |
PubChem CID | 3690 |
DrugBank | DB01181 |
UNII ID | UM20QQM95Y (ChemIDplus, GSRS) |