Ifosfamide
Ifex, Ifex/mesnex, Ifosfamide, Ifosfamide/mesna (ifosfamide) is a small molecule pharmaceutical. Ifosfamide was first approved as Ifex on 1988-12-30. It is used to treat b-cell chronic lymphocytic leukemia, breast neoplasms, hodgkin disease, lung neoplasms, and non-hodgkin lymphoma amongst others in the USA.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Ifosfamide (discontinued: Ifosfamide)
CombinationsIfex/mesnex (discontinued: Ifex/mesnex, Ifosfamide/mesna)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| ifex | New Drug Application | 2024-12-02 |
| ifosfamide | New Drug Application | 2024-12-02 |
Indications
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Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
Code | Description |
|---|---|
| J9208 | Injection, ifosfamide, 1 gram |
Clinical
Clinical Trials
538 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Testicular neoplasms | D013736 | — | C62 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ifosfamide |
| INN | ifosfamide |
| Description | Ifosfamide is the simplest member of the class of ifosfamides that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by 2-chloroethyl groups on both the nitrogen atoms respectively. It is a nitrogen mustard alkylating agent used in the treatment of advanced breast cancer. It has a role as an antineoplastic agent, an immunosuppressive agent, an alkylating agent, an environmental contaminant and a xenobiotic. |
| Classification | Small molecule |
| Drug class | phosphoro-derivatives; isophosphoramide mustard derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=P1(NCCCl)OCCCN1CCCl |
Identifiers
| PDB | — |
| CAS-ID | 3778-73-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1024 |
| ChEBI ID | 5864 |
| PubChem CID | 3690 |
| DrugBank | DB01181 |
| UNII ID | UM20QQM95Y (ChemIDplus, GSRS) |
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Additional graphs summarizing 22,005 documents
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Safety
Black-box Warning
Black-box warning for: Ifex, Ifosfamide
Adverse Events
Top Adverse Reactions
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21,008 adverse events reported
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