Ibutilide
Corvert, Ibutilide (ibutilide) is a small molecule pharmaceutical. Ibutilide was first approved as Corvert on 1995-12-28. It is used to treat atrial fibrillation, atrial flutter, and cardiac arrhythmias in the USA. The pharmaceutical is active against voltage-gated inwardly rectifying potassium channel KCNH2; potassium voltage-gated channel subfamily H member 2.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Corvert, Ibutilide (discontinued: Ibutilide)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| corvert | New Drug Application | 2024-01-25 |
| ibutilide fumarate | ANDA | 2024-03-13 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| atrial fibrillation | EFO_0000275 | D001281 | I48.0 |
| atrial flutter | EFO_0003911 | D001282 | — |
| cardiac arrhythmias | EFO_0004269 | D001145 | I49.9 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J1742 | Injection, ibutilide fumarate, 1 mg |
Clinical
Clinical Trials
9 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | — | 1 | 4 | 5 |
| Long qt syndrome | D008133 | HP_0001657 | I45.81 | — | 1 | — | 3 | — | 4 |
| Torsades de pointes | D016171 | EFO_0005307 | I47.21 | — | 1 | — | 1 | — | 2 |
| Drug-induced abnormalities | D000014 | — | — | — | — | — | 2 | — | 2 |
Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Jervell-lange nielsen syndrome | D029593 | Orphanet_90647 | I45.8 | — | 1 | — | — | — | 1 |
| Sudden death | D003645 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ibutilide |
| INN | ibutilide |
| Description | Ibutilide is an organic amino compound and a member of benzenes. |
| Classification | Small molecule |
| Drug class | class III antiarrhythmic agents |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 122647-31-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL533 |
| ChEBI ID | 5856 |
| PubChem CID | 60753 |
| DrugBank | DB00308 |
| UNII ID | 2436VX1U9B (ChemIDplus, GSRS) |
Target
Agency Approved
KCNH2
KCNH2
Organism
Homo sapiens
Gene name
KCNH2
Gene synonyms
ERG, ERG1, HERG
NCBI Gene ID
Protein name
potassium voltage-gated channel subfamily H member 2
Protein synonyms
Eag homolog, Eag-related protein 1, ERG-1, Ether-a-go-go-related gene potassium channel 1, ether-a-go-go-related potassium channel protein, Ether-a-go-go-related protein 1, H-ERG, hERG-1, hERG1, human ether-a-go-go-related, long QT syndrome type 2, potassium channel, voltage gated eag related subfamily H, member 2, potassium voltage-gated channel, subfamily H (eag-related), member 2, Voltage-gated potassium channel subunit Kv11.1
Uniprot ID
Mouse ortholog
Kcnh2 (16511)
potassium voltage-gated channel subfamily H member 2 (O35989)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,012 documents
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Safety
Black-box Warning
Black-box warning for: Corvert
Adverse Events
Top Adverse Reactions
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45 adverse events reported
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