Iboctadekin
Iboctadekin is a protein pharmaceutical. It is currently being investigated in clinical studies.
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Clinical
Clinical Trials
89 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syndrome | D013577 | — | — | 2 | — | — | 1 | 3 | 6 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 1 | — | 1 | 2 | 4 |
| Acute kidney injury | D058186 | — | N17 | — | — | — | 1 | 2 | 3 |
| Mucocutaneous lymph node syndrome | D009080 | EFO_0004246 | M30.3 | — | — | 1 | 1 | — | 2 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | 1 | 1 | 2 |
| Fibrosis | D005355 | — | — | — | — | — | 1 | 1 | 2 |
| Periodontal diseases | D010510 | — | K05.6 | — | — | — | 1 | 1 | 2 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | — | 1 | 1 | 2 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | — | 1 | 1 | 2 |
| Hepatitis c | D006526 | — | B19.2 | — | — | — | 1 | — | 1 |
Show 9 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 3 | 2 | 1 | — | — | 5 |
| Lymphoproliferative disorders | D008232 | Orphanet_2442 | D47.9 | — | 1 | 3 | — | — | 4 |
| X-linked genetic diseases | D040181 | — | — | — | 1 | 2 | — | — | 3 |
| Infections | D007239 | EFO_0000544 | — | — | 1 | 1 | — | 2 | 3 |
| Iga deficiency | D017098 | EFO_1001929 | — | — | — | 2 | — | — | 2 |
| Sars-cov-2 | D000086402 | — | — | — | 1 | 1 | — | — | 1 |
| Ischemic stroke | D000083242 | — | — | — | — | 1 | — | — | 1 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 1 | — | — | 1 |
| Ischemia | D007511 | EFO_0000556 | — | — | — | 1 | — | — | 1 |
| Cerebral infarction | D002544 | — | I63 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Inflammation | D007249 | MP_0001845 | — | — | 1 | — | — | 6 | 7 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 5 | 1 | — | — | — | 6 |
| Neoplasms | D009369 | — | C80 | 5 | 1 | — | — | — | 5 |
| Covid-19 | D000086382 | — | U07.1 | — | 2 | — | — | 1 | 3 |
| Juvenile arthritis | D001171 | EFO_1002007 | M08 | 1 | 1 | — | — | 1 | 3 |
| Sepsis | D018805 | EFO_0001420 | A41.9 | — | 1 | — | — | 1 | 2 |
| Toxemia | D014115 | — | — | — | 1 | — | — | 1 | 2 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 2 | 1 | — | — | — | 2 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 2 | 1 | — | — | — | 2 |
| Melanoma | D008545 | — | — | 1 | 2 | — | — | — | 2 |
Show 14 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 5 | — | — | — | — | 5 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 3 | — | — | — | — | 3 |
| Colorectal neoplasms | D015179 | — | — | 3 | — | — | — | — | 3 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 3 | — | — | — | — | 3 |
| Myeloid leukemia | D007951 | — | C92 | 3 | — | — | — | — | 3 |
| Recurrence | D012008 | — | — | 3 | — | — | — | — | 3 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | 1 | 2 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 2 | — | — | — | — | 2 |
| Myelodysplastic syndromes | D009190 | — | D46 | 2 | — | — | — | — | 2 |
| Multiple myeloma | D009101 | — | C90.0 | 2 | — | — | — | — | 2 |
Show 15 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | — | — | — | 5 | 5 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 3 | 3 |
| Renal insufficiency | D051437 | — | N19 | — | — | — | — | 3 | 3 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | — | — | — | — | 2 | 2 |
| Urticaria | D014581 | EFO_0005531 | L50 | — | — | — | — | 2 | 2 |
| Aggressive periodontitis | D010520 | EFO_0006342 | K05.2 | — | — | — | — | 2 | 2 |
| Chronic periodontitis | D055113 | EFO_0006343 | K05.3 | — | — | — | — | 2 | 2 |
| Pediatric obesity | D063766 | — | — | — | — | — | — | 2 | 2 |
| Fever | D005334 | — | R50.9 | — | — | — | — | 2 | 2 |
| Stem cell transplantation | D033581 | — | — | — | — | — | — | 1 | 1 |
Show 65 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Iboctadekin |
| INN | iboctadekin |
| Description | Iboctadekin is a protein pharmaceutical. It is currently being investigated in clinical studies. |
| Classification | Protein |
| Drug class | interleukins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >4HJJ:H|Anti-IL12 Anti-IL18 DFab Heavy Chain
EVTLRESGPALVKPTQTLTLTCTFSGFSLSKSVMGVSWIRQPPGKALEWLAHIYWDDDKYYNPSLSARLTISKDTSKNQV
VLTMTNMDPVDTATYYCARRGIRSAMDYWGQGTTVTVSSASTKGPEVQLVQSGTEVKKPGESLKISCKGSGYTVTSYWIG
WVRQMPGKGLEWMGFIYPGDSETRYSPTFQGQVTISADKSFNTAFLQWSSLKASDTAMYYCARVGSGWYPYTFDIWGQGT
MVTVSSASTKGPSVFPLAPSSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS
SSLGTQTYICNVNHKPSNTKVDKKVEPK
>4HJJ:L|Anti-IL12 Anti-IL18 DFab Light Chain
DIVMTQSPDSLAVSLGERATINCKASQSVSNDVAWYQQKPGQPPKLLIYYASNRYTGVPDRFSGSGSGTDFTLTISSLEA
EDVAVYYCQQDYNSPWTFGGGTKVEIKRTVAAPEIVMTQSPATLSVSPGERATLSCRASESISSNLAWYQQKPGQAPRLF
IYTASTRATDIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPSITFGQGTRLEIKRTVAAPSVFIFPPSDEQLK
SGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVT
KSFNRGE |
Target
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Variants
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Financial
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Trends
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Safety
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Adverse Events
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