Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Syndrome | D013577 | — | — | 2 | — | — | 1 | 2 | 5 |
Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | 1 | — | 1 | 2 | 4 |
Acute kidney injury | D058186 | HP_0001919 | N17 | — | — | — | 1 | 2 | 3 |
Mucocutaneous lymph node syndrome | D009080 | EFO_0004246 | M30.3 | — | — | 1 | 1 | — | 2 |
Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | — | 1 | 1 | 2 |
Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | — | 1 | 1 | 2 |
Hepatitis c | D006526 | — | B19.2 | — | — | — | 1 | — | 1 |
Traumatic brain injuries | D000070642 | — | S06 | — | — | — | 1 | — | 1 |
Brain injuries | D001930 | — | S06.9 | — | — | — | 1 | — | 1 |
Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | 1 | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Lymphoma | D008223 | — | C85.9 | 3 | 2 | 1 | — | — | 5 |
Lymphoproliferative disorders | D008232 | Orphanet_2442 | D47.9 | — | 1 | 3 | — | — | 4 |
X-linked genetic diseases | D040181 | — | — | — | 1 | 2 | — | — | 3 |
Infections | D007239 | EFO_0000544 | — | — | 1 | 1 | — | 2 | 3 |
Iga deficiency | D017098 | EFO_1001929 | — | — | — | 2 | — | — | 2 |
Sars-cov-2 | D000086402 | — | — | — | 1 | 1 | — | — | 1 |
Ischemic stroke | D000083242 | — | — | — | — | 1 | — | — | 1 |
Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 1 | — | — | 1 |
Ischemia | D007511 | EFO_0000556 | — | — | — | 1 | — | — | 1 |
Cerebral infarction | D002544 | — | I63 | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Non-hodgkin lymphoma | D008228 | — | C85.9 | 5 | 1 | — | — | — | 6 |
Inflammation | D007249 | MP_0001845 | — | — | 1 | — | — | 5 | 6 |
Neoplasms | D009369 | — | C80 | 4 | 1 | — | — | — | 4 |
Covid-19 | D000086382 | — | — | — | 2 | — | — | 1 | 3 |
Sepsis | D018805 | HP_0100806 | A41.9 | — | 1 | — | — | 1 | 2 |
Toxemia | D014115 | — | — | — | 1 | — | — | 1 | 2 |
Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 2 | 1 | — | — | — | 2 |
Ovarian epithelial carcinoma | D000077216 | — | — | 2 | 1 | — | — | — | 2 |
Melanoma | D008545 | — | — | 1 | 2 | — | — | — | 2 |
Juvenile arthritis | D001171 | EFO_1002007 | M08 | 1 | 1 | — | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Leukemia | D007938 | — | C95 | 5 | — | — | — | — | 5 |
Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 3 | — | — | — | — | 3 |
Colorectal neoplasms | D015179 | — | — | 3 | — | — | — | — | 3 |
Myeloid leukemia acute | D015470 | — | C92.0 | 3 | — | — | — | — | 3 |
Myeloid leukemia | D007951 | — | C92 | 3 | — | — | — | — | 3 |
Recurrence | D012008 | — | — | 3 | — | — | — | — | 3 |
Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | 1 | 2 |
B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 2 | — | — | — | — | 2 |
Myelodysplastic syndromes | D009190 | — | D46 | 2 | — | — | — | — | 2 |
Multiple myeloma | D009101 | — | C90.0 | 2 | — | — | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Periodontitis | D010518 | EFO_0000649 | K05.3 | — | — | — | — | 5 | 5 |
Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 2 | 2 |
Insulin resistance | D007333 | HP_0000855 | — | — | — | — | — | 2 | 2 |
Renal insufficiency | D051437 | HP_0000083 | N19 | — | — | — | — | 2 | 2 |
Urticaria | D014581 | EFO_0005531 | L50 | — | — | — | — | 2 | 2 |
Aggressive periodontitis | D010520 | EFO_0006342 | K05.2 | — | — | — | — | 2 | 2 |
Chronic periodontitis | D055113 | EFO_0006343 | K05.3 | — | — | — | — | 2 | 2 |
Stem cell transplantation | D033581 | — | — | — | — | — | — | 1 | 1 |
Morbid obesity | D009767 | EFO_0001074 | — | — | — | — | — | 1 | 1 |
Weight loss | D015431 | HP_0001824 | — | — | — | — | — | 1 | 1 |
Drug common name | Iboctadekin |
INN | iboctadekin |
Description | Iboctadekin is a protein pharmaceutical. It is currently being investigated in clinical studies. |
Classification | Protein |
Drug class | interleukins |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | >4HJJ:H|Anti-IL12 Anti-IL18 DFab Heavy Chain
EVTLRESGPALVKPTQTLTLTCTFSGFSLSKSVMGVSWIRQPPGKALEWLAHIYWDDDKYYNPSLSARLTISKDTSKNQV
VLTMTNMDPVDTATYYCARRGIRSAMDYWGQGTTVTVSSASTKGPEVQLVQSGTEVKKPGESLKISCKGSGYTVTSYWIG
WVRQMPGKGLEWMGFIYPGDSETRYSPTFQGQVTISADKSFNTAFLQWSSLKASDTAMYYCARVGSGWYPYTFDIWGQGT
MVTVSSASTKGPSVFPLAPSSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS
SSLGTQTYICNVNHKPSNTKVDKKVEPK
>4HJJ:L|Anti-IL12 Anti-IL18 DFab Light Chain
DIVMTQSPDSLAVSLGERATINCKASQSVSNDVAWYQQKPGQPPKLLIYYASNRYTGVPDRFSGSGSGTDFTLTISSLEA
EDVAVYYCQQDYNSPWTFGGGTKVEIKRTVAAPEIVMTQSPATLSVSPGERATLSCRASESISSNLAWYQQKPGQAPRLF
IYTASTRATDIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPSITFGQGTRLEIKRTVAAPSVFIFPPSDEQLK
SGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVT
KSFNRGE |