Iberdomide
Iberdomide is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target protein cereblon.
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Clinical
Clinical Trials
48 clinical trials
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Indications Phases 4
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 1 | — | — | — | — | 1 |
| Plasma cell neoplasms | D054219 | — | — | 1 | — | — | — | — | 1 |
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Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Iberdomide |
| INN | iberdomide |
| Description | Iberdomide is an experimental thalidomide analog that works as an cereblon E3 ligase modulator; it has a higher binding affinity than lenalidomide or pomalidomide. It is developed by Bristol Myers Squibb for various cancers and was also tested in people with lupus.
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| Classification | Small molecule |
| Drug class | thalidomide derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C1CC[C@H](N2Cc3c(OCc4ccc(CN5CCOCC5)cc4)cccc3C2=O)C(=O)N1 |
Identifiers
| PDB | — |
| CAS-ID | 1323403-33-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3989927 |
| ChEBI ID | — |
| PubChem CID | 67335295 |
| DrugBank | DB12101 |
| UNII ID | 8V66F27X44 (ChemIDplus, GSRS) |
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94 adverse events reported
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