ISCALIMAB
Iscalimab is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against tumor necrosis factor receptor superfamily member 5.
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Commercial
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Clinical
Clinical Trials
13 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sjogren's syndrome | D012859 | EFO_0000699 | M35.0 | — | 3 | — | — | — | 3 |
| Syndrome | D013577 | — | — | — | 3 | — | — | — | 3 |
| Graft rejection | D006084 | — | — | — | 2 | — | — | — | 2 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | 1 | — | — | — | 1 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 1 | — | — | — | 1 |
| Hidradenitis suppurativa | D017497 | — | L73.2 | — | 1 | — | — | — | 1 |
| Hidradenitis | D016575 | — | — | — | 1 | — | — | — | 1 |
| Systemic lupus erythematosus | D008180 | HP_0002725 | M32 | — | 1 | — | — | — | 1 |
| Lupus nephritis | D008181 | EFO_0005761 | — | — | 1 | — | — | — | 1 |
| Nephritis | D009393 | — | N05 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 1 | — | — | — | — | 1 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ISCALIMAB |
| INN | iscalimab |
| Description | Iscalimab is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against tumor necrosis factor receptor superfamily member 5. |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL4298210 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 0628T707D0 (ChemIDplus, GSRS) |
Target
Agency Approved
CD40
CD40
Organism
Homo sapiens
Gene name
CD40
Gene synonyms
TNFRSF5
NCBI Gene ID
Protein name
tumor necrosis factor receptor superfamily member 5
Protein synonyms
B cell surface antigen CD40, B cell-associated molecule, B-cell surface antigen CD40, Bp50, CD40, CD40 molecule, TNF receptor superfamily member 5, CD40L receptor, CDw40
Uniprot ID
Mouse ortholog
Cd40 (21939)
tumor necrosis factor receptor superfamily member 5 (Q99NE3)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 228 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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126 adverse events reported
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