Tradename | Company | Number | Date | Products |
---|---|---|---|---|
SIKLOS | addmedica | N-208843 RX | 2017-12-21 | 2 products, RLD, RS |
DROXIA | CHEPLAPHARM Arzneimittel | N-016295 RX | 1998-02-25 | 3 products, RLD |
HYDREA | CHEPLAPHARM Arzneimittel | N-016295 RX | 1982-01-01 | 1 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
droxia | New Drug Application | 2023-12-13 |
hydrea | New Drug Application | 2023-12-13 |
hydroxyurea | ANDA | 2023-11-08 |
siklos | New Drug Application | 2024-01-04 |
Expiration | Code | ||
---|---|---|---|
HYDROXYUREA, SIKLOS, ADDMEDICA SAS | |||
2024-12-21 | ODE-177 |
Code | Description |
---|---|
S0176 | Hydroxyurea, oral, 500 mg |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Sickle cell anemia | D000755 | EFO_0000697 | D57 | 23 | 38 | 18 | 5 | 46 | 119 |
Polycythemia vera | D011087 | — | D45 | 1 | 6 | 9 | 1 | 5 | 22 |
Hiv infections | D015658 | EFO_0000764 | B20 | 3 | 7 | 1 | 1 | 5 | 17 |
Essential thrombocythemia | D013920 | — | D47.3 | — | 2 | 6 | 1 | 2 | 10 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Myeloid leukemia acute | D015470 | — | C92.0 | 4 | 10 | 3 | — | 3 | 15 |
Leukemia | D007938 | — | C95 | 2 | 5 | 9 | — | 1 | 14 |
Beta-thalassemia | D017086 | Orphanet_848 | D56.1 | 2 | 9 | 3 | — | 1 | 10 |
Primary myelofibrosis | D055728 | — | D47.4 | 2 | 3 | 6 | — | 1 | 10 |
Thalassemia | D013789 | EFO_1001996 | D56 | 2 | 3 | 1 | — | 4 | 9 |
Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 2 | 3 | 3 | — | 2 | 8 |
Stroke | D020521 | EFO_0000712 | I63.9 | — | 2 | 3 | — | 3 | 8 |
Myelodysplastic syndromes | D009190 | — | D46 | 1 | 4 | 1 | — | 2 | 7 |
Glioblastoma | D005909 | EFO_0000515 | — | 3 | 3 | 1 | — | — | 7 |
Hematologic diseases | D006402 | EFO_0005803 | D75.9 | 1 | 2 | 3 | — | 1 | 6 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Head and neck neoplasms | D006258 | — | — | 3 | 10 | — | — | — | 11 |
Hemoglobin sc disease | D006450 | EFO_1001797 | D57.2 | — | 4 | — | — | 4 | 8 |
Squamous cell carcinoma of head and neck | D000077195 | — | — | 4 | 3 | — | — | — | 6 |
Gliosarcoma | D018316 | — | — | 2 | 2 | — | — | — | 4 |
Metabolic brain diseases | D001928 | — | G93.41 | 2 | 3 | — | — | 1 | 4 |
Central nervous system neoplasms | D016543 | — | — | 2 | 2 | — | — | — | 4 |
Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | — | 2 | — | — | 1 | 3 |
Thrombocytosis | D013922 | HP_0001894 | D75.83 | 1 | 2 | — | — | 1 | 3 |
Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | 3 | 1 | — | — | — | 3 |
Esophageal neoplasms | D004938 | — | C15 | 1 | 3 | — | — | — | 3 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Salivary gland neoplasms | D012468 | EFO_0003826 | D11 | 2 | — | — | — | — | 2 |
Verrucous carcinoma | D018289 | — | — | 2 | — | — | — | — | 2 |
Basal cell carcinoma | D002280 | — | — | 1 | — | — | — | — | 1 |
Adenoid cystic carcinoma | D003528 | — | — | 1 | — | — | — | — | 1 |
Inverted papilloma | D018308 | — | — | 1 | — | — | — | — | 1 |
Olfactory esthesioneuroblastoma | D018304 | EFO_1000407 | — | 1 | — | — | — | — | 1 |
Mucoepidermoid carcinoma | D018277 | — | — | 1 | — | — | — | — | 1 |
Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
Tongue neoplasms | D014062 | EFO_0003871 | C02.9 | 1 | — | — | — | — | 1 |
Pneumonia | D011014 | EFO_0003106 | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Ischemic stroke | D000083242 | — | — | — | — | — | — | 1 | 1 |
Bone marrow neoplasms | D019046 | — | — | — | — | — | — | 1 | 1 |
Only child | D009863 | — | — | — | — | — | — | 1 | 1 |
Infections | D007239 | EFO_0000544 | — | — | — | — | — | 1 | 1 |
Yin deficiency | D016710 | — | — | — | — | — | — | 1 | 1 |
Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | — | — | — | — | 1 | 1 |
Hemolytic anemia | D000743 | — | D55-D59 | — | — | — | — | 1 | 1 |
Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | — | — | — | 1 | 1 |
Peripheral nervous system diseases | D010523 | HP_0009830 | G64 | — | — | — | — | 1 | 1 |
Hemophilia a | D006467 | EFO_0007267 | D66 | — | — | — | — | 1 | 1 |
Drug common name | Hydroxyurea |
INN | hydroxycarbamide |
Description | Hydroxyurea is a member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease. It has a role as a DNA synthesis inhibitor, an EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor, an antineoplastic agent, a genotoxin, an antimetabolite, a teratogenic agent, a radical scavenger, an immunomodulator and an antimitotic. It is a member of ureas and a one-carbon compound. |
Classification | Small molecule |
Drug class | — |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | NC(=O)NO |
PDB | — |
CAS-ID | 127-07-1 |
RxCUI | — |
ChEMBL ID | CHEMBL467 |
ChEBI ID | 44423 |
PubChem CID | 3657 |
DrugBank | DB01005 |
UNII ID | X6Q56QN5QC (ChemIDplus, GSRS) |