Tradename | Company | Number | Date | Products |
---|---|---|---|---|
HYDREA | CHEPLAPHARM Arzneimittel | N-016295 RX | 1982-01-01 | 1 products, RLD, RS |
XROMI | Nova Laboratories | N-216593 RX | 2024-04-04 | 1 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
droxia | New Drug Application | 2024-08-15 |
hydrea | New Drug Application | 2024-08-15 |
hydroxyurea | ANDA | 2025-03-04 |
siklos | New Drug Application | 2025-02-05 |
xromi | New Drug Application | 2025-01-03 |
Expiration | Code | ||
---|---|---|---|
HYDROXYUREA, SIKLOS, ADDMEDICA SAS | |||
2024-12-21 | ODE-177 |
Code | Description |
---|---|
S0176 | Hydroxyurea, oral, 500 mg |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | 1 | — | — | 1 | 2 |
Beta-thalassemia | D017086 | Orphanet_848 | D56.1 | 1 | 1 | — | — | — | 1 |
Thalassemia | D013789 | EFO_1001996 | D56 | 1 | 1 | — | — | — | 1 |
Hemoglobin sc disease | D006450 | EFO_1001797 | D57.2 | 1 | 1 | — | — | — | 1 |
Drug common name | Hydroxyurea |
INN | hydroxycarbamide |
Description | Hydroxyurea is a member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease. It has a role as a DNA synthesis inhibitor, an EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor, an antineoplastic agent, a genotoxin, an antimetabolite, a teratogenic agent, a radical scavenger, an immunomodulator and an antimitotic. It is a member of ureas and a one-carbon compound. |
Classification | Small molecule |
Drug class | — |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | NC(=O)NO |
PDB | — |
CAS-ID | 127-07-1 |
RxCUI | — |
ChEMBL ID | CHEMBL467 |
ChEBI ID | 44423 |
PubChem CID | 3657 |
DrugBank | DB01005 |
UNII ID | X6Q56QN5QC (ChemIDplus, GSRS) |