Cyanokit(hydroxocobalamin)
Cyanokit, Hydroxocobalamin (hydroxocobalamin) is a small molecule pharmaceutical. Hydroxocobalamin was first approved as Hydroxocobalamin on 1982-01-01. It is used to treat alcoholic neuropathy, diabetic neuropathies, multiple sclerosis, pernicious anemia, and poisoning in the USA. It has been approved in Europe to treat poisoning.
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Commercial
Trade Name
FDA
EMA
Cyanokit, Hydroxocobalamin (discontinued: Alpharedisol, Cyanokit, Hydroxocobalamin, Hydroxomin)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| aronamin gold | unapproved drug other | 2018-12-12 |
| cyanokit | New Drug Application | 2023-04-27 |
| hydroxocobalamin | ANDA | 2020-01-18 |
Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
B: Blood and blood forming organ drugs
— B03: Antianemic preparations
— B03B: Vitamin b12 and folic acid
— B03BA: Vitamin b12 (cyanocobalamin and analogues)
— B03BA03: Hydroxocobalamin
— B03BA53: Hydroxocobalamin, combinations
V: Various drug classes in atc
— V03: All other therapeutic products
— V03A: All other therapeutic products
— V03AB: Antidotes
— V03AB33: Hydroxocobalamin
HCPCS
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Clinical
Clinical Trials
653 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vitamin b 12 deficiency | D014806 | EFO_0000734 | E53.8 | 2 | 4 | 2 | 4 | 43 | 53 |
| Anemia | D000740 | HP_0001903 | D64.9 | — | 3 | 7 | 7 | 31 | 46 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | 2 | 1 | 1 | 18 | 21 |
| Iron deficiencies | D000090463 | — | — | — | 1 | 1 | 4 | 15 | 20 |
| Peripheral nervous system diseases | D010523 | HP_0009830 | G64 | 1 | 3 | 1 | 4 | 10 | 18 |
| Iron-deficiency anemia | D018798 | HP_0001891 | D50 | — | 1 | 1 | 4 | 13 | 18 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | 1 | 3 | — | 1 | 12 | 17 |
| Syndrome | D013577 | — | — | — | 2 | 3 | 1 | 11 | 16 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | 1 | 3 | 2 | 1 | 9 | 15 |
| Hyperhomocysteinemia | D020138 | — | — | — | 1 | 2 | 1 | 11 | 15 |
Show 76 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 13 | 9 | — | 3 | 24 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | 15 | 6 | — | 3 | 23 |
| Covid-19 | D000086382 | — | — | 1 | 2 | 3 | — | 7 | 12 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 3 | 1 | — | 9 | 12 |
| T-cell lymphoma | D016399 | — | — | 5 | 5 | 3 | — | — | 10 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | 1 | — | 2 | — | 7 | 10 |
| T-cell lymphoma peripheral | D016411 | — | — | 4 | 4 | 3 | — | — | 9 |
| Autistic disorder | D001321 | HP_0000717 | F84.0 | — | 2 | 2 | — | 6 | 8 |
| Carcinoma | D002277 | — | C80.0 | 2 | 4 | 2 | — | — | 7 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 1 | 1 | — | 6 | 7 |
Show 89 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | 2 | — | — | 11 | 14 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 3 | — | — | 3 | 8 |
| Micronutrients | D018977 | — | — | — | 1 | — | — | 4 | 5 |
| Mucositis | D052016 | EFO_1001898 | — | — | 4 | — | — | — | 4 |
| Aging | D000375 | GO_0007568 | R41.81 | — | 1 | — | — | 3 | 4 |
| Sars-cov-2 | D000086402 | — | — | 2 | 2 | — | — | 1 | 3 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 2 | — | — | 1 | 3 |
| Nasopharyngeal carcinoma | D000077274 | — | — | — | 3 | — | — | — | 3 |
| Nasopharyngeal neoplasms | D009303 | — | — | — | 3 | — | — | — | 3 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | — | 1 | — | — | 2 | 3 |
Show 52 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carpal tunnel syndrome | D002349 | EFO_0004143 | G56.0 | 1 | — | — | — | 3 | 4 |
| Weight loss | D015431 | HP_0001824 | — | 1 | — | — | — | 3 | 4 |
| Heart failure | D006333 | HP_0001635 | I50 | 1 | — | — | — | 3 | 4 |
| Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | 1 | 2 |
| T-cell lymphoma cutaneous | D016410 | — | — | 2 | — | — | — | — | 2 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 1 | — | — | — | 1 | 2 |
| Cognition disorders | D003072 | — | — | 1 | — | — | — | 1 | 2 |
| Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
| Chordoma | D002817 | EFO_0000334 | — | 1 | — | — | — | — | 1 |
| Pancreatic ductal carcinoma | D021441 | — | — | 1 | — | — | — | — | 1 |
Show 13 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Folic acid deficiency | D005494 | EFO_0001070 | E53.8 | — | — | — | — | 11 | 11 |
| Deglutition disorders | D003680 | HP_0002015 | R13.1 | — | — | — | — | 8 | 8 |
| Gyrate atrophy | D015799 | — | — | — | — | — | — | 6 | 6 |
| Vitamin a deficiency | D014802 | EFO_1001237 | E50 | — | — | — | — | 6 | 6 |
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | — | — | — | — | 6 | 6 |
| Cerebral palsy | D002547 | — | G80 | — | — | — | — | 4 | 4 |
| Cerebral small vessel diseases | D059345 | — | — | — | — | — | — | 4 | 4 |
| Progressive bulbar palsy | D010244 | EFO_0003783 | G12.1 | — | — | — | — | 4 | 4 |
| Postoperative cognitive complications | D000079690 | — | — | — | — | — | — | 3 | 3 |
| Growth disorders | D006130 | — | — | — | — | — | — | 3 | 3 |
Show 194 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Hydroxocobalamin |
| INN | hydroxocobalamin |
| Description | Hydroxocobalamin, also known as vitamin B12a and hydroxycobalamin, is a vitamin found in food and used as a dietary supplement. As a supplement it is used to treat vitamin B12 deficiency including pernicious anemia. Other uses include treatment for cyanide poisoning, Leber's optic atrophy, and toxic amblyopia. It is given by injection into a muscle or vein.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 13422-51-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2103737 |
| ChEBI ID | 27786 |
| PubChem CID | 44475014 |
| DrugBank | DB00200 |
| UNII ID | Q40X8H422O (ChemIDplus, GSRS) |
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Hydroxocobalamin
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Safety
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537 adverse events reported
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