Hydroquinone
Tri-luma (hydroquinone) is a small molecule pharmaceutical. Hydroquinone was first approved as Tri-luma on 2002-01-18. It is used to treat hyperpigmentation in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| skin and connective tissue diseases | D017437 |
Trade Name
FDA
EMA
Combinations
Tri-luma
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 141010 hydroquinone 4% | unapproved drug other | 2020-07-02 |
| 141011 hydroquinone 6% | unapproved drug other | 2020-07-02 |
| 141016 hydrocortisone 0.5% / hydroquinone 4% / tretinoin 0.025% | unapproved drug other | 2020-07-02 |
| 141017 hydrocortisone 0.5% / hydroquinone 6% / tretinoin 0.025% | unapproved drug other | 2020-07-02 |
| 141030 hydroquinone 8% | unapproved drug other | 2020-07-02 |
| 141055 hydroquinone 6% | unapproved drug other | 2020-07-02 |
| 141060 hydrocortisone 0.5% / hydroquinone 4% / tretinoin 0.025% | unapproved drug other | 2020-07-02 |
| 141061 hydrocortisone 0.5% / hydroquinone 8% / tretinoin 0.025% | unapproved drug other | 2020-07-02 |
| 141067 hydroquinone 8% | unapproved drug other | 2020-07-02 |
| activator light | OTC monograph not final | 2013-11-06 |
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Indications
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Agency Specific
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Clinical
Clinical Trials
46 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Melanosis | D008548 | HP_0001480 | L81.1 | 1 | 4 | 7 | 9 | 10 | 30 |
| Hyperpigmentation | D017495 | HP_0000953 | — | — | 1 | — | 1 | 2 | 4 |
| Skin pigmentation | D012880 | EFO_0003784 | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sepsis | D018805 | HP_0100806 | A41.9 | — | — | 1 | — | — | 1 |
| Septic shock | D012772 | — | A48.3 | — | — | 1 | — | — | 1 |
| Hyperhomocysteinemia | D020138 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Skin diseases | D012871 | — | L00-L99 | — | — | — | — | 1 | 1 |
| Skin aging | D015595 | EFO_0005422 | — | — | — | — | — | 1 | 1 |
| Low back pain | D017116 | HP_0003419 | M54.5 | — | — | — | — | 1 | 1 |
| Back pain | D001416 | HP_0003418 | M54 | — | — | — | — | 1 | 1 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | — | — | — | 1 | 1 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | — | — | — | 1 | 1 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | — | 1 | 1 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | — | — | — | — | 1 | 1 |
| Pigmentation | D010858 | CHEBI_26130 | — | — | — | — | — | 1 | 1 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Hydroquinone |
| INN | — |
| Description | Hydroquinone is a benzenediol comprising benzene core carrying two hydroxy substituents para to each other. It has a role as a cofactor, a carcinogenic agent, an Escherichia coli metabolite, a human xenobiotic metabolite, a skin lightening agent, an antioxidant and a mouse metabolite. It is a benzenediol and a member of hydroquinones. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Oc1ccc(O)cc1 |
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Estimated US medical usage
Hydroquinone
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Safety
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903 adverse events reported
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