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Drug ReportsHydrochlorothiazide
Moduretic 5-50, Coaprovel(hydrochlorothiazide)
/ Hydrochlorothiazide, Actelsar, Aldactazide, Aldoril, Amlodipine Besylate / Hydrochlorothiazide / Olmesartan Medoxomil, Amlodipine Besylate / Hydrochlorothiazide / Valsartan, Amturnide, Atacand, Avalide, Benicar, Cam-ap-es, CoAprovel, Copalia, Dafiro, Diovan, Dutoprol, Esimil, Exforge, H.r, Hydra-zide, Hydrap-es, Hydro-reserp, Hydro-serp, Hydrochlorothiazide, Hydrochlorothiazide /, Hydrochlorothiazide / Irbesartan, Hydrochlorothiazide / Olmesartan Medoxomil, Hydrochlorothiazide / Valsartan, Hydropres, Hydroserpine (r), Hyzaar, Ifirmacombi, Inderide, Inderide-, Irbesartan / Hydrochlorothiazide, Karvezide, Kinzalkomb, Lopressor, Lotensin, Maxzide, Micardis, Microzide, Normozide, Oreticyl, PritorPlus, Rasilez, Rasitrio, Riprazo, Ser-a-gen, Ser-ap-es, Serpasil-esidrix, Sprimeo, Tekturna, Teveten, Timolide, Tolucombi, Trandate, Tribenzor, Unipres, Vaseretic, Viskazide, Zestoretic, Ziac (hydrochlorothiazide) is a small molecule pharmaceutical. Hydrochlorothiazide was first approved as Moduretic 5-50 on 1982-01-01. It is used to treat edema, heart failure, hypertension, and nephrotic syndrome in the USA. It has been approved in Europe to treat essential hypertension and hypertension. The pharmaceutical is active against solute carrier family 12 member 3.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Microzide (generic drugs available since 1982-01-01, discontinued: Esidrix, Hydro, Hydrodiuril, Oretic, Zide)
Combinations
Aldactazide, Atacand, Avalide, Benicar, Diovan, Exforge, Hyzaar, Lopressor, Lotensin, Maxzide, Micardis, Tribenzor, Vaseretic, Zestoretic, Ziac (generic drugs available since 1982-01-01, discontinued: Accuretic, Aldoril, Aldoril d30, Aldoril d50, Amturnide, Apresazide, Apresoline-esidrix, Cam-ap-es, Capozide, Dutoprol, Dyazide, Esimil, H.r, Hydra-zide, Hydrap-es, Hydro-reserp, Hydro-ride, Hydro-serp, Hydropres, Hydroserpine (r), Inderide, Inderide-, Moduretic, Monopril-hct, Normozide, Oreticyl, Prinzide, Ser-a-gen, Ser-ap-es, Serpasil-esidrix, Tekturna, Teveten, Timolide, Trandate, Unipres, Uniretic, Viskazide)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Aliskiren hemifumarate
+
Amlodipine besylate
+
Hydrochlorothiazide
Tradename
Company
Number
Date
Products
AMTURNIDENovartisN-200045 DISCN2010-12-21
5 products
Hide discontinued
Aliskiren hemifumarate
+
Hydrochlorothiazide
Tradename
Company
Number
Date
Products
TEKTURNA HCTNoden PharmaN-022107 DISCN2008-01-18
4 products, RLD
Hide discontinued
Amiloride hydrochloride
+
Hydrochlorothiazide
Tradename
Company
Number
Date
Products
MODURETIC 5-50Merck KGaAN-018201 DISCN1982-01-01
1 products, RLD
Hide discontinued
Amlodipine besylate
+
Hydrochlorothiazide
+
Olmesartan medoxomil
Tradename
Company
Number
Date
Products
TRIBENZORCosette Pharmaceuticals N-200175 RX2010-07-23
5 products, RLD, RS
Amlodipine besylate
+
Hydrochlorothiazide
+
Valsartan
Tradename
Company
Number
Date
Products
EXFORGE HCTNovartisN-022314 RX2009-04-30
5 products, RLD, RS
Benazepril hydrochloride
+
Hydrochlorothiazide
Tradename
Company
Number
Date
Products
LOTENSIN HCTValidus PharmaceuticalsN-020033 RX1992-05-19
3 products, RLD
Show 1 discontinued
Bisoprolol fumarate
+
Hydrochlorothiazide
Tradename
Company
Number
Date
Products
ZIACTevaN-020186 RX1993-03-26
3 products, RLD
Candesartan cilexetil
+
Hydrochlorothiazide
Tradename
Company
Number
Date
Products
ATACAND HCTANI PHARMSN-021093 RX2000-09-05
3 products, RLD
Captopril
+
Hydrochlorothiazide
Tradename
Company
Number
Date
Products
CAPOZIDE 25/15Bristol Myers SquibbN-018709 DISCN1984-10-12
1 products, RLD
CAPOZIDE 25/25Bristol Myers SquibbN-018709 DISCN1984-10-12
1 products, RLD
CAPOZIDE 50/25Bristol Myers SquibbN-018709 DISCN1984-10-12
1 products, RLD
CAPOZIDE 50/15Bristol Myers SquibbN-018709 DISCN1984-10-12
1 products, RLD
Hide discontinued
Deserpidine
+
Hydrochlorothiazide
Tradename
Company
Number
Date
Products
ORETICYL 25AbbVieN-012148 DISCN1982-01-01
1 products
ORETICYL FORTEAbbVieN-012148 DISCN1982-01-01
1 products
ORETICYL 50AbbVieN-012148 DISCN1982-01-01
1 products
Hide discontinued
Enalapril maleate
+
Hydrochlorothiazide
Tradename
Company
Number
Date
Products
VASERETICBausch Health CompaniesN-019221 RX1986-10-31
2 products, RLD, RS
Eprosartan mesylate
+
Hydrochlorothiazide
Tradename
Company
Number
Date
Products
TEVETEN HCTAbbVieN-021268 DISCN2001-11-01
2 products
Hide discontinued
Fosinopril sodium
+
Hydrochlorothiazide
Tradename
Company
Number
Date
Products
MONOPRIL-HCTBristol Myers SquibbN-020286 DISCN1994-11-30
2 products, RLD
Hide discontinued
Guanethidine monosulfate
+
Hydrochlorothiazide
Tradename
Company
Number
Date
Products
ESIMILNovartisN-013553 DISCN1982-01-01
1 products
Hide discontinued
Hydralazine hydrochloride
+
Hydrochlorothiazide
Tradename
Company
Number
Date
Products
APRESOLINE-ESIDRIXNovartisN-012026 DISCN1982-01-01
1 products
Hide discontinued
Hydralazine hydrochloride
+
Hydrochlorothiazide
+
Reserpine
Tradename
Company
Number
Date
Products
SER-AP-ESNovartisN-012193 DISCN1982-01-01
1 products
Hide discontinued
Hydrochlorothiazide
Tradename
Company
Number
Date
Products
MICROZIDETevaN-020504 RX1996-12-27
1 products, RLD, RS
Show 3 discontinued
Hydrochlorothiazide
+
Irbesartan
Tradename
Company
Number
Date
Products
AVALIDESanofiN-020758 RX1997-09-30
2 products, RLD, RS
Show 1 discontinued
Hydrochlorothiazide
+
Labetalol hydrochloride
Tradename
Company
Number
Date
Products
TRANDATE HCTGSKN-019174 DISCN1987-04-10
4 products
NORMOZIDEMerck Sharp & DohmeN-019046 DISCN1987-04-06
4 products
Hide discontinued
Hydrochlorothiazide
+
Lisinopril
Tradename
Company
Number
Date
Products
ZESTORETICAlmatica PharmaN-019888 RX1989-07-20
3 products, RLD
Show 1 discontinued
Hydrochlorothiazide
+
Losartan potassium
Tradename
Company
Number
Date
Products
HYZAAROrganonN-020387 RX1995-04-28
3 products, RLD
Hydrochlorothiazide
+
Methyldopa
Tradename
Company
Number
Date
Products
ALDORIL 15Merck KGaAN-013402 DISCN1982-01-01
1 products
ALDORIL 25Merck KGaAN-013402 DISCN1982-01-01
1 products
ALDORIL D30Merck KGaAN-013402 DISCN1982-01-01
1 products
ALDORIL D50Merck KGaAN-013402 DISCN1982-01-01
1 products
Hide discontinued
Hydrochlorothiazide
+
Metoprolol succinate
Tradename
Company
Number
Date
Products
DUTOPROLConcordia LaboratoriesN-021956 DISCN2006-08-28
3 products, RLD
Hide discontinued
Hydrochlorothiazide
+
Metoprolol tartrate
Tradename
Company
Number
Date
Products
LOPRESSOR HCTValidus PharmaceuticalsN-018303 RX1984-12-31
1 products, RLD
Show 1 discontinued
Hydrochlorothiazide
+
Moexipril hydrochloride
Tradename
Company
Number
Date
Products
UNIRETICUCBN-020729 DISCN1997-06-27
3 products
Hide discontinued
Hydrochlorothiazide
+
Olmesartan medoxomil
Tradename
Company
Number
Date
Products
BENICAR HCTCosette Pharmaceuticals N-021532 RX2003-06-05
3 products, RLD, RS
Hydrochlorothiazide
+
Pindolol
Tradename
Company
Number
Date
Products
VISKAZIDENovartisN-018872 DISCN1987-07-22
2 products
Hide discontinued
Hydrochlorothiazide
+
Propranolol hydrochloride
Tradename
Company
Number
Date
Products
INDERIDE LA 80/50WyethN-019059 DISCN1985-07-03
1 products
INDERIDE LA 120/50WyethN-019059 DISCN1985-07-03
1 products
INDERIDE LA 160/50WyethN-019059 DISCN1985-07-03
1 products
INDERIDE-40/25WYETH PHARMS INCN-018031 DISCN1982-01-01
1 products, RLD
INDERIDE-80/25WYETH PHARMS INCN-018031 DISCN1982-01-01
1 products, RLD
Hide discontinued
Hydrochlorothiazide
+
Quinapril hydrochloride
Tradename
Company
Number
Date
Products
ACCURETICPfizerN-020125 DISCN1999-12-28
3 products, RLD
Hide discontinued
Hydrochlorothiazide
+
Reserpine
Tradename
Company
Number
Date
Products
HYDROPRES 25Merck KGaAN-011958 DISCN1982-01-01
1 products
HYDROPRES 50Merck KGaAN-011958 DISCN1982-01-01
1 products
SERPASIL-ESIDRIX #1NovartisN-011878 DISCN1982-01-01
1 products
SERPASIL-ESIDRIX #2NovartisN-011878 DISCN1982-01-01
1 products
Hide discontinued
Hydrochlorothiazide
+
Spironolactone
Tradename
Company
Number
Date
Products
ALDACTAZIDEMylanN-012616 RX1982-12-30
2 products, RLD, RS
Hydrochlorothiazide
+
Telmisartan
Tradename
Company
Number
Date
Products
MICARDIS HCTBoehringer IngelheimN-021162 RX2000-11-17
3 products, RLD
Hydrochlorothiazide
+
Timolol maleate
Tradename
Company
Number
Date
Products
TIMOLIDE 10-25Merck KGaAN-018061 DISCN1982-01-01
1 products
Hide discontinued
Hydrochlorothiazide
+
Triamterene
Tradename
Company
Number
Date
Products
MAXZIDE-25Aurobindo PharmaN-019129 RX1988-05-13
1 products, RLD
MAXZIDEAurobindo PharmaN-019129 RX1984-10-22
1 products, RLD, RS
Show 1 discontinued
Hydrochlorothiazide
+
Valsartan
Tradename
Company
Number
Date
Products
DIOVAN HCTNovartisN-020818 RX1998-03-06
5 products, RLD
Labels
FDA
EMA
Brand Name
Status
Last Update
accureticNew Drug Application2023-09-18
aldactazideNew Drug Application2023-11-23
amiloride hydrochloride and hydrochlorothiazideANDA2023-02-04
amlodipine, valsartan and hydrochlorothiazideANDA2023-12-14
amlodipine, valsartan, hydrochlorothiazideANDA2022-09-30
atacandNew Drug Application2020-06-19
atacand hctNew Drug Application2020-05-07
avalideNew Drug Application2023-07-24
benazepril hydrochloride and hydrochlorothiazideANDA2023-09-30
benicarNew Drug Application2023-07-12
Show 60 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
edema—D004487R60.9
heart failureEFO_0003144D006333I50
hypertensionEFO_0000537D006973I10
nephrotic syndromeEFO_0004255D009404N04
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Aliskiren Hemifumarate / Hydrochlorothiazide, Tekturna Hct, Noden Pharma
86181722028-07-13DP
Amlodipine Besylate / Hydrochlorothiazide / Valsartan, Exforge Hct, Novartis
81015992023-05-16DP
84758392023-05-16DP
Aliskiren Hemifumarate / Amlodipine Besylate / Hydrochlorothiazide, Amturnide, Novartis
81832952023-05-16DP
ATC Codes
C: Cardiovascular system drugs
— C03: Diuretics
— C03A: Low-ceiling diuretics, thiazides
— C03AA: Thiazides, plain
— C03AA03: Hydrochlorothiazide
— C03AB: Thiazides and potassium in combination
— C03AB03: Hydrochlorothiazide and potassium
— C03AX: Thiazides, combinations with other drugs
— C03AX01: Hydrochlorothiazide, combinations
— C03E: Diuretics and potassium-sparing agents in combination
— C03EA: Low-ceiling diuretics and potassium-sparing agents
— C03EA01: Hydrochlorothiazide and potassium-sparing agents
— C09: Agents acting on the renin-angiotensin system
— C09B: Ace inhibitors, combinations
— C09BX: Ace inhibitors, other combinations in atc
— C09BX03: Ramipril, amlodipine and hydrochlorothiazide
— C09D: Angiotensin ii receptor blockers (arbs), combinations
— C09DX: Angiotensin ii receptor blockers (arbs), other combinations
— C09DX01: Valsartan, amlodipine and hydrochlorothiazide
— C09DX03: Olmesartan medoxomil, amlodipine and hydrochlorothiazide
— C09DX06: Candesartan, amlodipine and hydrochlorothiazide
— C09DX07: Irbesartan, amlodipine and hydrochlorothiazide
— C09X: Other agents acting on the renin-angiotensin system in atc
— C09XA: Renin-inhibitors
— C09XA52: Aliskiren and hydrochlorothiazide
— C09XA54: Aliskiren, amlodipine and hydrochlorothiazide
HCPCS
No data
Clinical
Clinical Trials
1983 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertensionD006973EFO_0000537I106952245282139777
Heart failureD006333HP_0001635I50421355645157
Healthy volunteers/patients———13121213149
Essential hypertensionD000075222—I1081646221099
Type 2 diabetes mellitusD003924EFO_0001360E11131013321175
Atrial fibrillationD001281EFO_0000275I48.02210131541
Cardiovascular diseasesD002318HP_0001626—161510839
Chronic renal insufficiencyD051436—N18433201038
HyperlipidemiasD006949HP_0003077E78.515291330
Coronary artery diseaseD003324—I25.1112161130
Show 138 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypercholesterolemiaD006937HP_0003124———7—310
Precursor cell lymphoblastic leukemia-lymphomaD054198—C91.0163——8
Cerebral hemorrhageD002543————2—35
Cognitive dysfunctionD060825HP_0001268G31.84—32——5
Aortic valve stenosisD001024HP_0001650——23—15
Pulmonary arterial hypertensionD000081029——111—14
Heart arrestD006323EFO_0009492I46—12—14
BurnsD002056—T30.0—44——4
SepsisD018805HP_0100806A41.9——1—23
NephrolithiasisD053040—N20.0—12—13
Show 40 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PharmacokineticsD010599——31——15
Iga vasculitisD011695EFO_1000965D69.023———4
AgingD000375GO_0007568R41.81—1——34
Atopic dermatitisD003876EFO_0000274L2031———4
Myeloid leukemia acuteD015470—C92.014———4
Down syndromeD004314EFO_0001064Q90—1——23
Alzheimer diseaseD000544EFO_0000249F0312——13
HypersensitivityD006967HP_0012393T78.40—1——23
Atrial remodelingD064752———1——12
Treatment-resistant schizophreniaD000090663———1——12
Show 48 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Morbid obesityD009767EFO_0001074—1———56
FastingD005215EFO_0002756—5———16
Therapeutic equivalencyD013810——5————5
Vascular stiffnessD059289——1———23
Prostatic neoplasmsD011471—C611———23
Colorectal neoplasmsD015179——1———23
Crohn diseaseD003424EFO_0000384K501———12
PsoriasisD011565EFO_0000676L401———12
Chronic painD059350HP_0012532—2————2
TachycardiaD013610HP_0001649R00.01———12
Show 15 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PainD010146EFO_0003843R52————33
AnesthesiaD000758——————33
HyperaldosteronismD006929HP_0011736E26————22
HeadacheD006261HP_0002315R51————22
Hematopoietic stem cell transplantationD018380——————22
Percutaneous coronary interventionD062645——————22
ExerciseD015444EFO_0000483—————22
Uterine cervical neoplasmsD002583HP_0030159—————22
DeliriumD003693—R41.0————22
Trisomy 18 syndromeD000073842—Q91.3————22
Show 128 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameHydrochlorothiazide
INNhydrochlorothiazide
Description
Hydrochlorothiazide is a benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure. It has a role as a xenobiotic, an environmental contaminant, a diuretic and an antihypertensive agent. It is a benzothiadiazine, a sulfonamide and an organochlorine compound.
Classification
Small molecule
Drug classdiuretics (thiazide derivatives)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
NS(=O)(=O)c1cc2c(cc1Cl)NCNS2(=O)=O
Identifiers
PDB—
CAS-ID58-93-5
RxCUI—
ChEMBL IDCHEMBL435
ChEBI ID5778
PubChem CID3639
DrugBankDB00999
UNII ID0J48LPH2TH (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
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Atacand – AstraZeneca
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Diovan – Novartis
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Exforge – Novartis
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Hydrochlorothiazide
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Aliskiren
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Hydrochlorothiazide
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Amiloride
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Hydrochlorothiazide
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Amlodipine
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Olmesartan
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Hydrochlorothiazide
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Amlodipine
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Valsartan
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Hydrochlorothiazide
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Benazepril
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Hydrochlorothiazide
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Bisoprolol
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Hydrochlorothiazide
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Captopril
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Hydrochlorothiazide
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Enalapril
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Hydrochlorothiazide
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Eprosartan
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Hydrochlorothiazide
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Fosinopril
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Hydrochlorothiazide
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Hydralazine
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Hydrochlorothiazide
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Hydralazine
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Reserpine
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Hydrochlorothiazide
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Hydrochlorothiazide
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Reserpine
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Telmisartan
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Triamterene
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Valsartan
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Trends
PubMed Central
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Additional graphs summarizing 30,771 documents
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Safety
Black-box Warning
Black-box warning for: Accuretic, Amlodipine, valsartan and hydrochlorothiazide, Amlodipine, valsartan, hydrochlorothiazide, Atacand, Atacand hct, Avalide, Benazepril hydrochloride and hydrochlorothiazide, Benicar, Benicar hct, Candesartan cilexetil and hydrochlorothiazide, Captopril and hydrochlorothiazide, Citalopram hydrobromide, Clopidogrel, Diovan, Diovan hct, Enalapril maleate and hydrochlorothiazide, Exforge, Exforge hct, Fosinopril sodium and hydrochlorothiazide, Hyzaar, Irbesartan and hydrochlorothiazide, Lisinopril, Lisinopril and hctz, Lisinopril and hydrochlorothiazide, Lisinopril with hydrochlorothiazide, Lisinopril-hydrochlorothiazide, Losartan potassium and hydrochlorothiazide, Losartan potassium and hydrochlorothiazide, Losartan potassium and hydrochlorothiazide losartan potassium hctz, Losartan potassium-hydrochlorothiazide, Lotensin, Lotensin hct, Micardis, Micardis hct, Olmesartan medoxomil / amlodipine besylate / hydrochlorothiazide, Olmesartan medoxomil and hydrochlorothiazide, Olmesartan medoxomil, amlodipine and hydrochlorothiazide, Olmesartan medoxomil, amlodipine and hydrochlorothiazide 20/5/12.5 mg, Olmesartan medoxomil, amlodipine and hydrochlorothiazide 20/5/12.5 mg olmesartan medoxomil, amlodipine and hydrochlorothiazide 40/10/12.5 mg olmesa..., Olmesartan medoxomil-hydrochlorothiazide, Quinapril and hydrochlorothiazide 20/12.5 quinapril and hydrochlorothiazide 10/12.5 quinapril and hydrochlorothiazide 20/25, Quinapril and hydrochlorothiazide, Quinapril and hydrochlorothiazide 10/12.5, Quinapril and hydrochlorothiazide quinapril hydrochloride and hydrochlorothiazide, Quinapril hcl and hydrochlorothiazide, Quinapril hydrochloride and hydrochlorothiazide, Tekturna, Tekturna hct, Telmisartan and hydrochlorothiazide, Tribenzor, Valsartan and hydrochlorothiazide, Vaseretic, Zestoretic
Adverse Events
Top Adverse Reactions
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136,936 adverse events reported
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