Hydralazine
Bidil, Cam-ap-es, Dralserp, Hydra-zide, Hydralazine, Hydrap-es, Hydroserpine (r), Ser-a-gen, Ser-ap-es, Serpasil-apresoline, Unipres (hydralazine) is a small molecule pharmaceutical. Hydralazine was first approved as Apresoline on 1982-01-01. It is used to treat heart failure, malignant hypertension, and pulmonary hypertension in the USA.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| respiratory tract diseases | D012140 |
| cardiovascular diseases | D002318 |
Trade Name
FDA
EMA
Combinations
Bidil (generic drugs available since 1982-01-01, discontinued: Apresazide, Apresoline-esidrix, Cam-ap-es, Dralserp, Hydra-zide, Hydrap-es, Hydroserpine (r), Ser-a-gen, Ser-ap-es, Serpasil-apresoline, Unipres)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Hydralazine hydrochloride
Hydralazine hydrochloride
+
Hydrochlorothiazide
Hydralazine hydrochloride
+
Hydrochlorothiazide
+
Reserpine
Hydralazine hydrochloride
+
Isosorbide dinitrate
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| bidil | New Drug Application | 2020-07-29 |
| hydralazine | ANDA | 2022-02-15 |
| hydralazine hcl | ANDA | 2019-04-30 |
| hydralazine hydrochloride | ANDA | 2024-01-30 |
| hydralazine hydrocloride | 2006-09-19 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C02: Antihypertensives
— C02D: Arteriolar smooth muscle, agents acting on
— C02DB: Hydrazinophthalazine derivatives acting on arteriolar smooth muscle
— C02DB02: Hydralazine
— C02L: Antihypertensives and diuretics in combination
— C02LG: Hydrazinophthalazine derivatives and diuretics
— C02LG02: Hydralazine and diuretics
HCPCS
Code | Description |
|---|---|
| J0360 | Injection, hydralazine hcl, up to 20 mg |
Clinical
Clinical Trials
212 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 3 | 1 | 2 | 4 | 11 | 21 |
| Heart failure | D006333 | HP_0001635 | I50 | 1 | 3 | 3 | 4 | 6 | 16 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | 1 | 2 | 3 | 6 |
| Postoperative pain | D010149 | — | G89.18 | — | 3 | 2 | 2 | — | 5 |
| Chronic renal insufficiency | D051436 | — | N18 | — | — | — | 1 | 2 | 3 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | — | — | 2 | — | 2 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | — | — | 1 | 1 | 2 |
| Neuromuscular blockade | D019148 | — | — | — | — | — | 1 | 1 | 2 |
| Coronary artery disease | D003324 | — | I25.1 | — | — | — | 1 | 1 | 2 |
| Cardiogenic shock | D012770 | — | R57.0 | — | — | — | 1 | — | 1 |
Show 13 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Uterine cervical neoplasms | D002583 | HP_0030159 | — | — | 1 | 2 | — | 2 | 5 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | 1 | 1 | — | 1 | 3 |
| Hypercholesterolemia | D006937 | HP_0003124 | — | — | — | 1 | — | 2 | 3 |
| Pregnancy-induced hypertension | D046110 | — | O13 | — | 1 | 1 | — | 1 | 3 |
| Polycystic kidney diseases | D007690 | HP_0000113 | Q61.3 | 1 | — | 1 | — | — | 2 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | 1 | — | 1 | 2 |
| Overactive urinary bladder | D053201 | EFO_1000781 | N32.81 | — | — | 2 | — | — | 2 |
| Ectopic pregnancy | D011271 | — | O00 | 1 | 1 | 1 | — | — | 2 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | — | 1 | — | 1 | 2 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | — | 1 | — | 1 | 2 |
Show 11 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 2 | — | — | 3 | 5 |
| Cerebral hemorrhage | D002543 | — | — | — | 2 | — | — | 2 | 4 |
| Myelodysplastic syndromes | D009190 | — | D46 | — | 3 | — | — | — | 3 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 1 | — | — | 2 | 3 |
| Neoplasms | D009369 | — | C80 | — | 1 | — | — | 2 | 3 |
| Blood pressure | D001794 | EFO_0004325 | — | 1 | 1 | — | — | — | 2 |
| Rectal neoplasms | D012004 | — | — | 1 | 2 | — | — | — | 2 |
| Myeloid leukemia acute | D015470 | — | C92.0 | — | 2 | — | — | — | 2 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | — | 2 | — | — | — | 2 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | — | 2 | — | — | — | 2 |
Show 23 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | 1 | — | — | — | 2 | 3 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | 2 | 3 |
| Healthy volunteers/patients | — | — | — | 3 | — | — | — | — | 3 |
| Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | 2 | 3 |
| Hemorrhage | D006470 | MP_0001914 | R58 | 1 | — | — | — | — | 1 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 1 | — | — | — | — | 1 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | 1 | — | — | — | — | 1 |
| Hypoxia | D000860 | HP_0012418 | R09.02 | 1 | — | — | — | — | 1 |
| Drug interactions | D004347 | — | — | 1 | — | — | — | — | 1 |
| Nasal polyps | D009298 | HP_0100582 | J33 | 1 | — | — | — | — | 1 |
Show 1 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 6 | 6 |
| Anesthesia | D000758 | — | — | — | — | — | — | 3 | 3 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 3 | 3 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | — | — | — | 2 | 2 |
| Delirium | D003693 | — | R41.0 | — | — | — | — | 2 | 2 |
| Down syndrome | D004314 | EFO_0001064 | Q90 | — | — | — | — | 2 | 2 |
| Trisomy 18 syndrome | D000073842 | — | Q91.3 | — | — | — | — | 2 | 2 |
| Trisomy 13 syndrome | D000073839 | — | Q91.7 | — | — | — | — | 2 | 2 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | — | — | — | 2 | 2 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | — | 2 | 2 |
Show 111 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Hydralazine |
| INN | hydralazine |
| Description | Hydralazine is the 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent. It has a role as an antihypertensive agent and a vasodilator agent. It is a member of phthalazines, an azaarene, an ortho-fused heteroarene and a member of hydrazines. |
| Classification | Small molecule |
| Drug class | antihypertensives (hydrazine-phthalazines); antiarrhythmic/antianginal/antihypertensive agents, phthalazine like structure |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NNc1nncc2ccccc12 |
Identifiers
| PDB | — |
| CAS-ID | 86-54-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL276832 |
| ChEBI ID | 5775 |
| PubChem CID | 3637 |
| DrugBank | DB01275 |
| UNII ID | 26NAK24LS8 (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Hydralazine
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Hydralazine
+
Hydrochlorothiazide
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Hydralazine
+
Hydrochlorothiazide
+
Reserpine
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Hydralazine
+
Isosorbide dinitrate
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 25,032 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
4,738 adverse events reported
View more details
© 2020-2023 Collaborative Drug Discovery Inc. (CDD) | Terms of Use