Homatropine
Equipin, Homapin, Homatropine Methylbromide / Hydrocodone, Hycodan (homatropine) is a small molecule pharmaceutical. Homatropine was first approved as Homapin-10 on 1982-01-01. It is used to treat inflammation in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Combinations
Hycodan (generic drugs available since 1983-03-03, discontinued: Hydropane, Tussigon)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Homatropine methylbromide
+
Hydrocodone bitartrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| HYCODAN | Genus Lifesciences | N-005213 RX | 1988-07-26 | 2 products, RLD |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| homatropine hydrobromide ophthalmic | unapproved drug other | 2022-10-28 |
| hycodan | New Drug Application | 2021-12-29 |
| hydrocodone bitartrate and homatropine methylbromide | NDA authorized generic | 2024-08-05 |
| hydrocodone bitartrate and homatropine methylbromide syrup | ANDA | 2009-09-21 |
| hydromet | ANDA | 2024-05-31 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
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ATC Codes
A: Alimentary tract and metabolism drugs
— A03: Drugs for functional gastrointestinal disorders
— A03B: Belladonna and derivatives containing drugs, plain for functional gastrointestinal disorders
— A03BB: Belladonna alkaloids, semisynthetic, quaternary ammonium compounds for functional gastrointestinal disorders
— A03BB06: Homatropine methylbromide
— A03C: Antispasmodics in combination with psycholeptics
— A03CB: Belladonna and derivatives in combination with psycholeptics
— A03CB04: Homatropine methylbromide and psycholeptics
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01F: Mydriatics and cycloplegics
— S01FA: Anticholinergic mydriatics and cycloplegics
— S01FA05: Homatropine
HCPCS
No data
Clinical
Clinical Trials
195 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | 4 | 9 | 11 | 8 | 5 | 37 |
| Postoperative pain | D010149 | — | G89.18 | 5 | 1 | 9 | 13 | 6 | 34 |
| Acute pain | D059787 | — | R52 | 4 | 8 | 6 | 1 | 1 | 20 |
| Low back pain | D017116 | HP_0003419 | M54.5 | — | 2 | 9 | 2 | 2 | 15 |
| Back pain | D001416 | HP_0003418 | M54 | — | 2 | 10 | 2 | 1 | 15 |
| Chronic pain | D059350 | HP_0012532 | — | — | 2 | 5 | 2 | 3 | 12 |
| Vomiting | D014839 | HP_0002013 | R11.1 | — | — | 4 | 1 | 3 | 8 |
| Nausea | D009325 | HP_0002018 | R11.0 | — | — | 4 | 1 | 3 | 8 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | 2 | 3 | 2 | — | 7 |
| Bone fractures | D050723 | EFO_0003931 | T14.8 | 1 | — | — | 4 | 1 | 6 |
Show 53 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Shoulder pain | D020069 | HP_0030834 | M25.51 | — | — | 2 | — | 2 | 4 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | — | 1 | — | 1 | 3 |
| Anterior cruciate ligament injuries | D000070598 | — | — | — | 1 | 2 | — | — | 2 |
| Head and neck neoplasms | D006258 | — | — | 1 | — | 1 | — | — | 2 |
| Mucositis | D052016 | EFO_1001898 | — | 1 | — | 1 | — | — | 2 |
| Tibial meniscus injuries | D000070600 | — | — | — | — | 1 | — | — | 1 |
| Multiple myeloma | D009101 | — | C90.0 | — | — | 1 | — | — | 1 |
| Lymphoma | D008223 | — | C85.9 | — | — | 1 | — | — | 1 |
| Nephrolithiasis | D053040 | — | N20.0 | — | — | 1 | — | — | 1 |
| Kidney calculi | D007669 | EFO_0004253 | N20 | — | — | 1 | — | — | 1 |
Show 10 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | 2 | 2 | — | — | 2 | 6 |
| Emergencies | D004630 | — | — | — | 1 | — | — | 2 | 3 |
| Musculoskeletal pain | D059352 | — | — | 1 | 1 | — | — | — | 2 |
| Corneal injuries | D065306 | HP_0000559 | — | — | 1 | — | — | — | 1 |
| Eye injuries | D005131 | — | S00-S09 | — | 1 | — | — | — | 1 |
| Back injuries | D019567 | — | — | — | 1 | — | — | — | 1 |
| Abdominal neoplasms | D000008 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 14 | — | — | — | — | 14 |
| Drug interactions | D004347 | — | — | 1 | — | — | — | 2 | 3 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | 2 | 3 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 2 | — | — | — | — | 2 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | 2 | — | — | — | — | 2 |
| Hepatic insufficiency | D048550 | — | — | 2 | — | — | — | — | 2 |
| Thyroid diseases | D013959 | HP_0000820 | E00-E07 | 1 | — | — | — | — | 1 |
| Parathyroid diseases | D010279 | — | E21.5 | 1 | — | — | — | — | 1 |
| Intervertebral disc degeneration | D055959 | HP_0008419 | — | 1 | — | — | — | — | 1 |
| Spondylolisthesis | D013168 | EFO_0007493 | M43.1 | 1 | — | — | — | — | 1 |
Show 4 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cancer pain | D000072716 | — | G89.3 | — | — | — | — | 2 | 2 |
| Personality disorders | D010554 | HP_0012075 | F60.6 | — | — | — | — | 2 | 2 |
| Hip fractures | D006620 | EFO_0003964 | S72.00 | — | — | — | — | 1 | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 1 | 1 |
| Corneal diseases | D003316 | — | H18.9 | — | — | — | — | 1 | 1 |
| Intractable pain | D010148 | — | — | — | — | — | — | 1 | 1 |
| Femoracetabular impingement | D057925 | — | — | — | — | — | — | 1 | 1 |
| Obstetric labor complications | D007744 | — | — | — | — | — | — | 1 | 1 |
| Postpartum depression | D019052 | EFO_0007453 | F53.0 | — | — | — | — | 1 | 1 |
| Puerperal disorders | D011644 | EFO_0009683 | O89 | — | — | — | — | 1 | 1 |
Show 20 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Homatropine |
| INN | homatropine methylbromide |
| Description | Homatropine (Equipin, Isopto Homatropine) is an anticholinergic medication that is an antagonist at muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is used in eye drops as a cycloplegic (to temporarily paralyze accommodation), and as a mydriatic (to dilate the pupil).
|
| Classification | Small molecule |
| Drug class | atropine derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2 |
Identifiers
| PDB | — |
| CAS-ID | 87-00-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1618018 |
| ChEBI ID | 5747 |
| PubChem CID | 6321423 |
| DrugBank | DB00725 |
| UNII ID | 68JRS2HC1C (ChemIDplus, GSRS) |
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Homatropine
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Homatropine
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Hydrocodone
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Additional graphs summarizing 1,553 documents
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Safety
Black-box Warning
Black-box warning for: Hycodan, Hydrocodone bitartrate and homatropine methylbromide, Hydromet
Adverse Events
Top Adverse Reactions
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289 adverse events reported
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