Histidine
Histidine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target pituitary adenylate cyclase-activating polypeptide type I receptor, solute carrier family 15 member 4, vasoactive intestinal polypeptide receptor 2, secretin receptor, carbonic anhydrase 7, carbonic anhydrase 5A, mitochondrial, carbonic anhydrase 1, sodium-coupled neutral amino acid transporter 5, vasoactive intestinal polypeptide receptor 1, carbonic anhydrase 14, and solute carrier family 15 member 3.
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Brand Name | Status | Last Update |
|---|---|---|
| aminosyn ii | New Drug Application | 2022-05-04 |
| aminosyn-pf | New Drug Application | 2022-07-21 |
| clinimix | New Drug Application | 2021-04-13 |
| clinimix e | New Drug Application | 2021-04-13 |
| clinisol | ANDA | 2018-06-01 |
| kabiven | New Drug Application | 2023-08-02 |
| novoseven | Biologic Licensing Application | 2010-08-06 |
| perikabiven | New Drug Application | 2023-08-07 |
| plenamine | ANDA | 2023-04-21 |
| premasol - sulfite-free (amino acid) | ANDA | 2022-08-04 |
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Clinical Trials
110 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Inflammation | D007249 | MP_0001845 | — | — | 1 | — | 1 | — | 2 |
| Psoriasis | D011565 | EFO_0000676 | L40 | 1 | — | — | 1 | — | 2 |
| Retinal vein occlusion | D012170 | EFO_1001157 | H34.81 | — | — | — | 1 | — | 1 |
| Asthma | D001249 | EFO_0000270 | J45 | — | — | — | 1 | — | 1 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | — | — | 1 | — | 1 |
| Pancreas transplantation | D016035 | — | — | — | — | — | 1 | — | 1 |
| Thoracic aortic aneurysm | D017545 | EFO_0004282 | — | — | — | — | 1 | — | 1 |
| Meningococcal infections | D008589 | EFO_0004249 | A39 | — | — | — | 1 | — | 1 |
| Inborn genetic diseases | D030342 | EFO_0000508 | — | — | — | — | 1 | — | 1 |
| Aging | D000375 | GO_0007568 | R41.81 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | U07.1 | 1 | 4 | 4 | — | — | 7 |
| Severe acute respiratory syndrome-related coronavirus | D045473 | NCBITaxon_227859 | — | — | 1 | 1 | — | — | 2 |
| Menkes kinky hair syndrome | D007706 | — | — | 1 | 1 | 1 | — | — | 2 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | — | 1 | 1 | — | — | 1 |
| Leukocyte disorders | D007960 | — | D72.9 | — | 1 | 1 | — | — | 1 |
| Macular edema | D008269 | — | — | — | — | 1 | — | — | 1 |
| Communicable diseases | D003141 | — | — | — | — | 1 | — | — | 1 |
| Virus diseases | D014777 | — | B34 | — | — | 1 | — | — | 1 |
| Rna virus infections | D012327 | — | — | — | — | 1 | — | — | 1 |
| Rabies | D011818 | — | A82 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 2 | — | — | 1 | 3 |
| Falciparum malaria | D016778 | EFO_0007444 | B50 | 1 | 1 | — | — | 2 | 3 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 1 | 1 | — | — | — | 2 |
| Chronic renal insufficiency | D051436 | — | N18 | 1 | 1 | — | — | — | 2 |
| Coronary artery disease | D003324 | — | I25.1 | — | 2 | — | — | — | 2 |
| Melanoma | D008545 | — | — | 1 | 2 | — | — | — | 2 |
| Mesothelioma | D008654 | — | C45 | — | 1 | — | — | — | 1 |
| Gonorrhea | D006069 | DOID_7551 | A54 | — | 1 | — | — | — | 1 |
| Retinitis pigmentosa | D012174 | HP_0000580 | H35.52 | 1 | 1 | — | — | — | 1 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 3 | — | — | — | 1 | 4 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 2 | — | — | — | — | 2 |
| Uterine cervical neoplasms | D002583 | HP_0030159 | — | 1 | — | — | — | 1 | 2 |
| Irritable bowel syndrome | D043183 | EFO_0000555 | K58 | 1 | — | — | — | — | 1 |
| Mycoses | D009181 | — | B35-B49 | 1 | — | — | — | — | 1 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 1 | — | — | — | — | 1 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | 1 | — | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | — | 1 |
| Triple negative breast neoplasms | D064726 | — | — | 1 | — | — | — | — | 1 |
| Chronic pain | D059350 | HP_0012532 | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malaria | D008288 | EFO_0001068 | B54 | — | — | — | — | 4 | 4 |
| Thrombocytopenia | D013921 | HP_0001873 | D69.6 | — | — | — | — | 1 | 1 |
| Intestinal diseases | D007410 | HP_0002242 | K63.9 | — | — | — | — | 1 | 1 |
| Hepatic encephalopathy | D006501 | — | K72.91 | — | — | — | — | 1 | 1 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | — | — | 1 | 1 |
| Cachexia | D002100 | HP_0004326 | R64 | — | — | — | — | 1 | 1 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | — | — | 1 | 1 |
| Oxidative stress | D018384 | EFO_1001905 | — | — | — | — | — | 1 | 1 |
| Metabolism | D008660 | GO_0008152 | — | — | — | — | — | 1 | 1 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Histidine |
| INN | histidine |
| Description | L-histidine is the L-enantiomer of the amino acid histidine. It has a role as a nutraceutical, a micronutrient, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a human metabolite, an algal metabolite and a mouse metabolite. It is a proteinogenic amino acid, a histidine and a L-alpha-amino acid. It is a conjugate base of a L-histidinium(1+). It is a conjugate acid of a L-histidinate(1-). It is an enantiomer of a D-histidine. It is a tautomer of a L-histidine zwitterion. |
| Classification | Small molecule |
| Drug class | H2-receptor antagonists (cimetidine type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N[C@@H](Cc1c[nH]cn1)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 71-00-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL17962 |
| ChEBI ID | 15971 |
| PubChem CID | 6274 |
| DrugBank | DB00117 |
| UNII ID | 4QD397987E (ChemIDplus, GSRS) |
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Safety
Black-box Warning
Black-box warning for: Aminosyn ii, Novoseven, Trepoxicam, Trepoxicam-7.5
Adverse Events
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238 adverse events reported
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