Histamine
Ceplene (histamine) is a small molecule pharmaceutical. Histamine was first approved as Histamine phosphate on 1982-01-01. It is used to treat allergic rhinitis seasonal and urticaria in the USA. It has been approved in Europe to treat myeloid leukemia acute. It is known to target carbonic anhydrase 7, histamine H2 receptor, histamine H1 receptor, histamine H4 receptor, carbonic anhydrase 5A, mitochondrial, histamine H3 receptor, and carbonic anhydrase 1.
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Brand Name | Status | Last Update |
|---|---|---|
| 2nd chance mobility pain relief | C200263 | 2024-01-08 |
| activon ultra strength arthritis | OTC monograph not final | 2015-04-22 |
| alo therapeutic massage | C200263 | 2023-11-10 |
| alo therapeutic massage pain relieving | C200263 | 2023-11-10 |
| amino active topical analgesic cream | C200263 | 2023-11-11 |
| arthritis pain relief | C200263 | 2024-12-11 |
| arthritis pain relief cream | OTC monograph not final | 2019-12-09 |
| australian dream back pain | C200263 | 2024-01-18 |
| back pain cream | OTC monograph not final | 2019-12-09 |
| bakers best arthritis pain relief | C200263 | 2023-11-11 |
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| allergic rhinitis seasonal | EFO_0003956 | D006255 | J30 |
| urticaria | EFO_0005531 | D014581 | L50 |
Agency Specific
FDA
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ATC Codes
L: Antineoplastic and immunomodulating agents
— L03: Immunostimulants
— L03A: Immunostimulants
— L03AX: Other immunostimulants in atc
— L03AX14: Histamine dihydrochloride
V: Various drug classes in atc
— V04: Diagnostic agents
— V04C: Other diagnostic agents in atc
— V04CG: Gastric secretion test diagnostic agents
— V04CG03: Histamine phosphate
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Clinical
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1550 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Weight gain | D015430 | — | — | — | — | — | 1 | — | 1 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | 4 | 8 | — | — | 1 | 11 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | 2 | 8 | — | — | 1 | 11 |
| Recurrence | D012008 | — | — | 2 | 6 | — | — | 2 | 9 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 5 | 3 | — | — | — | 7 |
| Hepatitis b | D006509 | — | — | 1 | 6 | — | — | — | 7 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | 1 | 6 | — | — | — | 7 |
| Body weight | D001835 | EFO_0004338 | — | — | 6 | — | — | 1 | 7 |
| Hypertension | D006973 | EFO_0000537 | I10 | 2 | 2 | — | — | 2 | 6 |
| Disease | D004194 | EFO_0000408 | R69 | 2 | 1 | — | — | 4 | 6 |
| Colorectal neoplasms | D015179 | — | — | 4 | 2 | — | — | 1 | 6 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | 4 | — | — | — | 2 | 6 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 1 | — | — | — | 3 | 4 |
| Fasting | D005215 | EFO_0002756 | — | 3 | — | — | — | — | 3 |
| Diarrhea | D003967 | — | R19.7 | 1 | — | — | — | 2 | 3 |
| Biological availability | D001682 | — | — | 3 | — | — | — | — | 3 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 3 | — | — | — | — | 3 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 2 | — | — | — | — | 2 |
| Hematologic neoplasms | D019337 | — | — | 1 | — | — | — | 1 | 2 |
| Alcohol-related disorders | D019973 | — | F10 | 1 | — | — | — | 1 | 2 |
| Hyperalgesia | D006930 | — | — | 1 | — | — | — | 1 | 2 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Histamine release | D006636 | — | — | — | — | — | — | 10 | 10 |
| Gastrointestinal diseases | D005767 | — | — | — | — | — | — | 6 | 6 |
| Necrosis | D009336 | — | — | — | — | — | — | 5 | 5 |
| Digestive system diseases | D004066 | EFO_0000405 | K92.9 | — | — | — | — | 5 | 5 |
| Osteonecrosis | D010020 | EFO_0004259 | M87 | — | — | — | — | 4 | 4 |
| Replacement arthroplasty knee | D019645 | — | — | — | — | — | — | 4 | 4 |
| Sleep deprivation | D012892 | — | F51.12 | — | — | — | — | 4 | 4 |
| Aortic valve stenosis | D001024 | EFO_0000266 | — | — | — | — | — | 4 | 4 |
| Rotator cuff injuries | D000070636 | — | M75.1 | — | — | — | — | 3 | 3 |
| Morphine dependence | D009021 | EFO_0005612 | — | — | — | — | — | 3 | 3 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Histamine |
| INN | — |
| Description | Histamine is a member of the class of imidazoles that is 1H-imidazole substituted at position C-4 by a 2-aminoethyl group. It has a role as a human metabolite, a mouse metabolite and a neurotransmitter. It is an aralkylamino compound and a member of imidazoles. It is a conjugate base of a histaminium. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NCCc1c[nH]cn1 |
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Safety
Black-box Warning
Black-box warning for: Positive skin test control - histamine
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680 adverse events reported
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