Hexachlorophene
Pre-op (hexachlorophene) is a small molecule pharmaceutical. Hexachlorophene was first approved as Scrubteam surgical spongebrush on 1982-01-01. It is used to treat acne vulgaris and communicable diseases in the USA. It is known to target N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D.
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Pre-op (discontinued: Dial, E-z scrub, Gamophen, Germa-medica mg, Hexa-germ, Hexascrub, Phiso-scrub, Phisohex, Scrubteam surgical spongebrush, Septi-soft, Septisol, Soy-dome, Turgex)
Drug Products
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Hexachlorophene
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PRE-OP | Davis & Geck | N-017433 RX | 1982-01-01 | 1 products, RLD, RS |
| PRE-OP II | Davis & Geck | N-017433 RX | 1982-01-01 | 1 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| bd e-z scrub | C200263 | 2024-12-13 |
| bd e-z scrub 107 | ANDA | 2024-12-12 |
| bd e-z scrub clorhexidine gluconate antiseptic | New Drug Application | 2012-01-11 |
| benzethonium chloride solution | OTC monograph not final | 2015-12-01 |
| dial | OTC monograph not final | 2014-02-24 |
| dial acne | OTC monograph final | 2014-06-06 |
| dial acne control deep cleansing body wash | OTC monograph final | 2014-07-01 |
| dial acne control deep cleansing face wash | OTC monograph final | 2014-07-01 |
| dial advanced clean | C200263 | 2024-11-11 |
| dial aloe | OTC monograph not final | 2014-05-27 |
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| acne vulgaris | EFO_0003894 | D000152 | L70 |
| communicable diseases | — | D003141 | — |
Agency Specific
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Clinical
Clinical Trials
992 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | — | — | — | 2 | — | 2 |
| Communicable diseases | D003141 | — | — | — | — | — | 1 | — | 1 |
| Surgical wound infection | D013530 | — | — | — | — | — | 1 | — | 1 |
| Respiratory tract diseases | D012140 | — | — | — | — | — | 1 | — | 1 |
| Respiration disorders | D012120 | — | J00-J99 | — | — | — | 1 | — | 1 |
| Staphylococcal infections | D013203 | — | A49.01 | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | U07.1 | 1 | 1 | — | — | — | 1 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Hexachlorophene |
| INN | hexachlorophene |
| Description | Hexachlorophene is an organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union. It has a role as an antiseptic drug, an acaricide, an antibacterial agent and an antifungal agrochemical. It is a polyphenol, a trichlorobenzene and a bridged diphenyl fungicide. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl |
Identifiers
| PDB | — |
| CAS-ID | 70-30-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL496 |
| ChEBI ID | 5693 |
| PubChem CID | 3598 |
| DrugBank | DB00756 |
| UNII ID | IWW5FV6NK2 (ChemIDplus, GSRS) |
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NAPEPLD
NAPEPLD
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Hexachlorophene
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Safety
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71,249 adverse events reported
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