Hexachlorophene
Pre-op (hexachlorophene) is a small molecule pharmaceutical. Hexachlorophene was first approved as Scrubteam surgical spongebrush on 1982-01-01. It is used to treat acne vulgaris and communicable diseases in the USA. It is known to target N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D.
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Pre-op (discontinued: Dial, E-z scrub, Gamophen, Germa-medica mg, Hexa-germ, Hexascrub, Phiso-scrub, Phisohex, Scrubteam surgical spongebrush, Septi-soft, Septisol, Soy-dome, Turgex)
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Hexachlorophene
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PRE-OP | Davis & Geck | N-017433 RX | 1982-01-01 | 1 products, RLD, RS |
| PRE-OP II | Davis & Geck | N-017433 RX | 1982-01-01 | 1 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| bd e-z scrub | C200263 | 2023-11-30 |
| bd e-z scrub 107 | ANDA | 2023-11-24 |
| bd e-z scrub clorhexidine gluconate antiseptic | New Drug Application | 2012-01-11 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| acne vulgaris | EFO_0003894 | D000152 | L70 |
| communicable diseases | — | D003141 | — |
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Clinical Trials
886 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 1 | 6 | 17 | 26 | 38 | 86 |
| Postoperative pain | D010149 | — | G89.18 | 2 | 4 | 3 | 13 | 38 | 59 |
| Surgical wound infection | D013530 | — | — | — | 5 | 11 | 18 | 26 | 58 |
| Communicable diseases | D003141 | — | — | 1 | 6 | 14 | 12 | 21 | 52 |
| Wounds and injuries | D014947 | — | T14.8 | — | 3 | 7 | 5 | 12 | 25 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 6 | 2 | 2 | 13 | 25 |
| Covid-19 | D000086382 | — | — | 5 | 8 | 1 | 6 | 6 | 24 |
| Wound infection | D014946 | — | — | — | 2 | 10 | 6 | 7 | 24 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | 2 | 3 | 15 | 20 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | 1 | 2 | 1 | 3 | 11 | 17 |
Show 136 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative complications | D011183 | — | — | — | 1 | 4 | — | 11 | 16 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | 2 | 2 | — | 4 | 8 |
| Retinal diseases | D012164 | HP_0000479 | H35.9 | 1 | 1 | 4 | — | 2 | 8 |
| Ulcer | D014456 | MPATH_579 | — | — | 1 | 2 | — | 5 | 8 |
| Neoplasms | D009369 | — | C80 | — | 2 | 2 | — | 4 | 7 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | 3 | 4 | — | 2 | 7 |
| Dental caries | D003731 | EFO_0003819 | K02 | 1 | 5 | 1 | — | — | 7 |
| Obstetric labor complications | D007744 | — | — | — | — | 2 | — | 4 | 6 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | 1 | 1 | — | 3 | 6 |
| Urinary retention | D016055 | HP_0000016 | R33 | — | 2 | 1 | — | 3 | 6 |
Show 63 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anesthesia | D000758 | — | — | — | 1 | — | — | 8 | 9 |
| Prostatic neoplasms | D011471 | — | C61 | — | 1 | — | — | 6 | 7 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | 1 | — | — | 4 | 6 |
| Carcinoma | D002277 | — | C80.0 | 1 | 2 | — | — | 3 | 6 |
| Rectal neoplasms | D012004 | — | — | — | 3 | — | — | 2 | 5 |
| Kidney transplantation | D016030 | — | — | 1 | 2 | — | — | 1 | 4 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | 2 | — | — | 1 | 4 |
| Coronary artery disease | D003324 | — | I25.1 | — | 1 | — | — | 3 | 4 |
| Spinal fusion | D013123 | — | — | — | 1 | — | — | 3 | 4 |
| Head and neck neoplasms | D006258 | — | — | — | 1 | — | — | 2 | 3 |
Show 74 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sepsis | D018805 | HP_0100806 | A41.9 | 1 | — | — | — | 4 | 5 |
| Rhinosinusitis | D000096825 | — | — | 1 | — | — | — | 1 | 2 |
| Disease | D004194 | EFO_0000408 | R69 | 1 | — | — | — | 1 | 2 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 1 | — | — | — | 1 | 2 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | 1 | — | — | — | 1 | 2 |
| Osteosarcoma | D012516 | — | — | 1 | — | — | — | — | 1 |
| Basal cell carcinoma | D002280 | — | — | 1 | — | — | — | — | 1 |
| Ingrown nails | D009263 | — | L60.0 | 1 | — | — | — | — | 1 |
| Rhinoplasty | D012225 | — | — | 1 | — | — | — | — | 1 |
| Diabetic angiopathies | D003925 | EFO_1000896 | — | 1 | — | — | — | — | 1 |
Show 5 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fistula | D005402 | — | — | — | — | — | — | 9 | 9 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | — | — | — | 6 | 6 |
| Pilonidal sinus | D010864 | HP_0010769 | L05 | — | — | — | — | 6 | 6 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 6 | 6 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | — | — | — | — | 5 | 5 |
| Rupture | D012421 | — | — | — | — | — | — | 5 | 5 |
| Cesarean section | D002585 | — | — | — | — | — | — | 4 | 4 |
| Fibrosis | D005355 | — | — | — | — | — | — | 4 | 4 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | — | — | 4 | 4 |
| Contraception | D003267 | — | — | — | — | — | — | 4 | 4 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Hexachlorophene |
| INN | hexachlorophene |
| Description | Hexachlorophene is an organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union. It has a role as an antiseptic drug, an acaricide, an antibacterial agent and an antifungal agrochemical. It is a polyphenol, a trichlorobenzene and a bridged diphenyl fungicide. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl |
Identifiers
| PDB | — |
| CAS-ID | 70-30-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL496 |
| ChEBI ID | 5693 |
| PubChem CID | 3598 |
| DrugBank | DB00756 |
| UNII ID | IWW5FV6NK2 (ChemIDplus, GSRS) |
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Hexachlorophene
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108 adverse events reported
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