Hexachlorophene
Pre-op (hexachlorophene) is a small molecule pharmaceutical. Hexachlorophene was first approved as Scrubteam surgical spongebrush on 1982-01-01. It is used to treat acne vulgaris and communicable diseases in the USA. It is known to target N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D.
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Pre-op (discontinued: Dial, E-z scrub, Gamophen, Germa-medica mg, Hexa-germ, Hexascrub, Phiso-scrub, Phisohex, Scrubteam surgical spongebrush, Septi-soft, Septisol, Soy-dome, Turgex)
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Hexachlorophene
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PRE-OP | Davis & Geck | N-017433 RX | 1982-01-01 | 1 products, RLD, RS |
| PRE-OP II | Davis & Geck | N-017433 RX | 1982-01-01 | 1 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| bd e-z scrub | C200263 | 2025-12-08 |
| bd e-z scrub 107 | ANDA | 2025-12-08 |
| benzethonium chloride solution | OTC monograph not final | 2015-12-01 |
| dial | OTC monograph not final | 2014-02-24 |
| dial acne | OTC monograph final | 2014-06-06 |
| dial acne control deep cleansing body wash | OTC monograph final | 2014-07-01 |
| dial acne control deep cleansing face wash | OTC monograph final | 2014-07-01 |
| dial advanced clean | C200263 | 2024-11-11 |
| dial aloe | OTC monograph not final | 2014-05-27 |
| dial aloe antibacterial soap | OTC monograph not final | 2010-01-27 |
Show 52 more
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| acne vulgaris | EFO_0003894 | D000152 | L70 |
| communicable diseases | — | D003141 | — |
Agency Specific
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Patent Expiration
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Clinical
Clinical Trials
1107 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 2 | 3 | 9 | 21 | 31 | 65 |
| Postoperative pain | D010149 | — | G89.18 | 3 | 5 | 3 | 11 | 45 | 65 |
| Surgical wound infection | D013530 | — | — | — | 5 | 11 | 19 | 30 | 63 |
| Communicable diseases | D003141 | — | — | 2 | 2 | 6 | 8 | 16 | 34 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | 3 | 4 | 26 | 33 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 7 | 2 | 2 | 17 | 29 |
| Covid-19 | D000086382 | — | U07.1 | 5 | 8 | 1 | 6 | 7 | 25 |
| Wounds and injuries | D014947 | — | T14.8 | — | 3 | 5 | 3 | 13 | 23 |
| Wound infection | D014946 | — | — | — | 2 | 8 | 5 | 8 | 22 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 3 | 2 | 4 | 11 | 19 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative complications | D011183 | — | — | — | 1 | 4 | — | 15 | 20 |
| Agnosia | D000377 | EFO_0007136 | F88 | — | 1 | 4 | — | 8 | 13 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | 4 | 4 | — | 3 | 9 |
| Prostatic neoplasms | D011471 | — | C61 | — | 2 | 1 | — | 6 | 9 |
| Dental caries | D003731 | EFO_0003819 | K02 | 1 | 5 | 2 | — | 1 | 9 |
| Lung neoplasms | D008175 | — | C34.90 | — | 2 | 2 | — | 4 | 8 |
| Neoplasms | D009369 | — | C80 | 1 | 1 | 1 | — | 5 | 8 |
| Anterior cruciate ligament injuries | D000070598 | — | — | — | — | 1 | — | 7 | 8 |
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | 4 | 2 | — | 1 | 7 |
| Ulcer | D014456 | MPATH_579 | — | — | 1 | 1 | — | 5 | 7 |
Show 73 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | — | 3 | — | — | 4 | 7 |
| Coronary artery disease | D003324 | — | I25.1 | — | 1 | — | — | 5 | 6 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | 1 | — | — | 4 | 6 |
| Kidney transplantation | D016030 | — | — | 1 | 2 | — | — | 2 | 5 |
| Head and neck neoplasms | D006258 | — | — | — | 1 | — | — | 4 | 5 |
| Renal insufficiency | D051437 | — | N19 | 1 | 1 | — | — | 4 | 5 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | 2 | — | — | 1 | 4 |
| Female genital neoplasms | D005833 | — | — | — | 1 | — | — | 3 | 4 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 2 | — | — | 2 | 4 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 1 | — | — | 3 | 4 |
Show 79 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Edema | D004487 | — | R60.9 | 1 | — | — | — | 3 | 4 |
| Myopia | D009216 | EFO_0003927 | H52.1 | 1 | — | — | — | 2 | 3 |
| Disease | D004194 | EFO_0000408 | R69 | 1 | — | — | — | 2 | 3 |
| Rhinosinusitis | D000096825 | — | — | 1 | — | — | — | 1 | 2 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 1 | — | — | — | 1 | 2 |
| Dermatitis | D003872 | — | L30.9 | 1 | — | — | — | 1 | 2 |
| Otomycosis | D059249 | — | — | 1 | — | — | — | 1 | 2 |
| Osteosarcoma | D012516 | — | — | 1 | — | — | — | — | 1 |
| Basal cell carcinoma | D002280 | — | — | 1 | — | — | — | — | 1 |
| Ingrown nails | D009263 | — | L60.0 | 1 | — | — | — | — | 1 |
Show 10 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fistula | D005402 | — | — | — | — | — | — | 9 | 9 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | — | — | — | — | 9 | 9 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | — | — | 8 | 8 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 7 | 7 |
| Shoulder pain | D020069 | — | M25.51 | — | — | — | — | 7 | 7 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | — | — | — | 6 | 6 |
| Pilonidal sinus | D010864 | — | L05 | — | — | — | — | 6 | 6 |
| Cesarean section | D002585 | — | — | — | — | — | — | 5 | 5 |
| Exercise | D015444 | EFO_0000483 | — | — | — | — | — | 5 | 5 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 5 | 5 |
Show 425 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Hexachlorophene |
| INN | hexachlorophene |
| Description | Hexachlorophene is an organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union. It has a role as an antiseptic drug, an acaricide, an antibacterial agent and an antifungal agrochemical. It is a polyphenol, a trichlorobenzene and a bridged diphenyl fungicide. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl |
Identifiers
| PDB | — |
| CAS-ID | 70-30-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL496 |
| ChEBI ID | 5693 |
| PubChem CID | 3598 |
| DrugBank | DB00756 |
| UNII ID | IWW5FV6NK2 (ChemIDplus, GSRS) |
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Hexachlorophene
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Safety
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72,180 adverse events reported
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