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AboutPricing
Drug ReportsHexachlorophene
Hexachlorophene
Pre-op (hexachlorophene) is a small molecule pharmaceutical. Hexachlorophene was first approved as Scrubteam surgical spongebrush on 1982-01-01. It is used to treat acne vulgaris and communicable diseases in the USA. It is known to target N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D.
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Events Timeline
5D
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3M
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YTD
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2Y
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FDA approval date
EMA approval date
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Study first post date
Last update post date
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Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Pre-op (discontinued: Dial, E-z scrub, Gamophen, Germa-medica mg, Hexa-germ, Hexascrub, Phiso-scrub, Phisohex, Scrubteam surgical spongebrush, Septi-soft, Septisol, Soy-dome, Turgex)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Hexachlorophene
Tradename
Company
Number
Date
Products
PRE-OPDavis & GeckN-017433 RX1982-01-01
1 products, RLD, RS
PRE-OP IIDavis & GeckN-017433 RX1982-01-01
1 products, RLD
Show 17 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
bd e-z scrubC2002632024-12-13
bd e-z scrub 107ANDA2024-12-12
bd e-z scrub clorhexidine gluconate antisepticNew Drug Application2012-01-11
benzethonium chloride solutionOTC monograph not final2015-12-01
dialOTC monograph not final2014-02-24
dial acneOTC monograph final2014-06-06
dial acne control deep cleansing body washOTC monograph final2014-07-01
dial acne control deep cleansing face washOTC monograph final2014-07-01
dial advanced cleanC2002632024-11-11
dial aloeOTC monograph not final2014-05-27
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
acne vulgarisEFO_0003894D000152L70
communicable diseases—D003141—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
D: Dermatologicals
— D08: Antiseptics and disinfectants
— D08A: Antiseptics and disinfectants
— D08AE: Phenol and derivatives, antiseptics and disinfectants
— D08AE01: Hexachlorophene
HCPCS
No data
Clinical
Clinical Trials
1011 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InfectionsD007239EFO_0000544————1—1
Surgical wound infectionD013530—————1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameHexachlorophene
INNhexachlorophene
Description
Hexachlorophene is an organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union. It has a role as an antiseptic drug, an acaricide, an antibacterial agent and an antifungal agrochemical. It is a polyphenol, a trichlorobenzene and a bridged diphenyl fungicide.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl
Identifiers
PDB—
CAS-ID70-30-4
RxCUI—
ChEMBL IDCHEMBL496
ChEBI ID5693
PubChem CID3598
DrugBankDB00756
UNII IDIWW5FV6NK2 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
NAPEPLD
NAPEPLD
Organism
Homo sapiens
Gene name
NAPEPLD
Gene synonyms
C7orf18
NCBI Gene ID
222236
Protein name
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
Protein synonyms
NAPE-hydrolyzing phospholipase D
Uniprot ID
Q769K1
Mouse ortholog
Napepld (242864)
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (Q8BH82)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Hexachlorophene
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 42,384 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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71,492 adverse events reported
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