Hexachlorophene
Pre-op (hexachlorophene) is a small molecule pharmaceutical. Hexachlorophene was first approved as Scrubteam surgical spongebrush on 1982-01-01. It is used to treat acne vulgaris and communicable diseases in the USA. It is known to target N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D.
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Pre-op (discontinued: Dial, E-z scrub, Gamophen, Germa-medica mg, Hexa-germ, Hexascrub, Phiso-scrub, Phisohex, Scrubteam surgical spongebrush, Septi-soft, Septisol, Soy-dome, Turgex)
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Hexachlorophene
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PRE-OP | Davis & Geck | N-017433 RX | 1982-01-01 | 1 products, RLD, RS |
| PRE-OP II | Davis & Geck | N-017433 RX | 1982-01-01 | 1 products, RLD |
Show 17 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| bd e-z scrub | C200263 | 2024-12-13 |
| bd e-z scrub 107 | ANDA | 2024-12-12 |
| bd e-z scrub clorhexidine gluconate antiseptic | New Drug Application | 2012-01-11 |
| benzethonium chloride solution | OTC monograph not final | 2015-12-01 |
| dial | OTC monograph not final | 2014-02-24 |
| dial acne | OTC monograph final | 2014-06-06 |
| dial acne control deep cleansing body wash | OTC monograph final | 2014-07-01 |
| dial acne control deep cleansing face wash | OTC monograph final | 2014-07-01 |
| dial advanced clean | C200263 | 2024-11-11 |
| dial aloe | OTC monograph not final | 2014-05-27 |
Show 54 more
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| acne vulgaris | EFO_0003894 | D000152 | L70 |
| communicable diseases | — | D003141 | — |
Agency Specific
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Clinical
Clinical Trials
1000 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 2 | 6 | 17 | 26 | 39 | 88 |
| Postoperative pain | D010149 | — | G89.18 | 2 | 5 | 3 | 11 | 41 | 61 |
| Surgical wound infection | D013530 | — | — | — | 5 | 11 | 18 | 27 | 59 |
| Communicable diseases | D003141 | — | — | 2 | 6 | 14 | 12 | 22 | 54 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 7 | 2 | 2 | 15 | 27 |
| Wounds and injuries | D014947 | — | T14.8 | — | 4 | 7 | 5 | 12 | 26 |
| Covid-19 | D000086382 | — | U07.1 | 5 | 8 | 1 | 6 | 7 | 25 |
| Wound infection | D014946 | — | — | — | 2 | 10 | 6 | 8 | 25 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | 2 | 3 | 17 | 22 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 3 | 2 | 4 | 10 | 18 |
Show 147 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative complications | D011183 | — | — | — | 1 | 4 | — | 11 | 16 |
| Neoplasms | D009369 | — | C80 | 1 | 2 | 2 | — | 5 | 9 |
| Lung neoplasms | D008175 | — | C34.90 | — | 2 | 2 | — | 4 | 8 |
| Retinal diseases | D012164 | — | H35.9 | 1 | 1 | 4 | — | 2 | 8 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | 4 | 4 | — | 2 | 8 |
| Ulcer | D014456 | MPATH_579 | — | — | 1 | 2 | — | 5 | 8 |
| Dental caries | D003731 | EFO_0003819 | K02 | 1 | 5 | 1 | — | — | 7 |
| Anterior cruciate ligament injuries | D000070598 | — | — | — | — | 1 | — | 6 | 7 |
| Obstetric labor complications | D007744 | — | — | — | — | 2 | — | 4 | 6 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 4 | 2 | — | 1 | 6 |
Show 66 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | — | 2 | — | — | 7 | 9 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | 1 | — | — | 4 | 6 |
| Carcinoma | D002277 | — | C80.0 | 1 | 2 | — | — | 3 | 6 |
| Kidney transplantation | D016030 | — | — | 1 | 2 | — | — | 2 | 5 |
| Coronary artery disease | D003324 | — | I25.1 | — | 1 | — | — | 4 | 5 |
| Rectal neoplasms | D012004 | — | — | — | 3 | — | — | 2 | 5 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | 2 | — | — | 1 | 4 |
| Pain management | D059408 | — | — | — | 1 | — | — | 2 | 3 |
| Head and neck neoplasms | D006258 | — | — | — | 1 | — | — | 2 | 3 |
| Spinal diseases | D013122 | — | M45-M49 | — | 1 | — | — | 2 | 3 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sepsis | D018805 | EFO_0001420 | A41.9 | 2 | — | — | — | 4 | 6 |
| Myopia | D009216 | EFO_0003927 | H52.1 | 1 | — | — | — | 2 | 3 |
| Rhinosinusitis | D000096825 | — | — | 1 | — | — | — | 1 | 2 |
| Disease | D004194 | EFO_0000408 | R69 | 1 | — | — | — | 1 | 2 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 1 | — | — | — | 1 | 2 |
| Dermatitis | D003872 | — | L30.9 | 1 | — | — | — | 1 | 2 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | 1 | — | — | — | 1 | 2 |
| Osteosarcoma | D012516 | — | — | 1 | — | — | — | — | 1 |
| Basal cell carcinoma | D002280 | — | — | 1 | — | — | — | — | 1 |
| Ingrown nails | D009263 | — | L60.0 | 1 | — | — | — | — | 1 |
Show 10 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fistula | D005402 | — | — | — | — | — | — | 9 | 9 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | — | — | — | — | 8 | 8 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | — | — | — | 6 | 6 |
| Pilonidal sinus | D010864 | — | L05 | — | — | — | — | 6 | 6 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 6 | 6 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | — | — | 6 | 6 |
| Shoulder pain | D020069 | — | M25.51 | — | — | — | — | 6 | 6 |
| Rupture | D012421 | — | — | — | — | — | — | 5 | 5 |
| Depression | D003863 | — | F33.9 | — | — | — | — | 5 | 5 |
| Intervertebral disc displacement | D007405 | EFO_1001800 | — | — | — | — | — | 5 | 5 |
Show 387 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Hexachlorophene |
| INN | hexachlorophene |
| Description | Hexachlorophene is an organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union. It has a role as an antiseptic drug, an acaricide, an antibacterial agent and an antifungal agrochemical. It is a polyphenol, a trichlorobenzene and a bridged diphenyl fungicide. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl |
Identifiers
| PDB | — |
| CAS-ID | 70-30-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL496 |
| ChEBI ID | 5693 |
| PubChem CID | 3598 |
| DrugBank | DB00756 |
| UNII ID | IWW5FV6NK2 (ChemIDplus, GSRS) |
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Hexachlorophene
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71,492 adverse events reported
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