Brand Name | Status | Last Update |
---|---|---|
adefovir dipivoxil | ANDA | 2024-09-17 |
hepsera | New Drug Application | 2009-10-27 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hepatitis b | D006509 | — | — | 5 | 18 | 24 | 50 | 20 | 114 |
Hepatitis | D006505 | HP_0012115 | K75.9 | 4 | 18 | 23 | 45 | 16 | 103 |
Chronic hepatitis b | D019694 | EFO_0004239 | B18.1 | 3 | 11 | 19 | 48 | 10 | 90 |
Hepatitis a | D006506 | EFO_0007305 | B15 | 3 | 15 | 22 | 37 | 14 | 88 |
Chronic hepatitis | D006521 | — | K73.9 | 2 | 5 | 14 | 26 | 7 | 53 |
Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | 1 | 1 | — | 3 | 4 | 8 |
Fibrosis | D005355 | — | — | 1 | 1 | — | 4 | 1 | 6 |
Carcinoma | D002277 | — | C80.0 | — | 1 | — | 2 | 2 | 5 |
Hepatocellular carcinoma | D006528 | — | C22.0 | — | 1 | — | 2 | 2 | 5 |
Liver neoplasms | D008113 | EFO_1001513 | C22.0 | — | 1 | — | 1 | 3 | 5 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hiv infections | D015658 | EFO_0000764 | B20 | 6 | 11 | 3 | — | 4 | 24 |
Infections | D007239 | EFO_0000544 | — | 1 | 2 | 3 | — | 1 | 7 |
Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 1 | — | 1 | — | 1 | 3 |
Chronic disease | D002908 | — | — | — | — | 1 | — | — | 1 |
Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | — | — | 1 | — | — | 1 |
Cytomegalovirus infections | D003586 | EFO_0001062 | B25 | — | — | 1 | — | — | 1 |
Communicable diseases | D003141 | — | — | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hepatitis b virus | D006515 | — | — | — | 2 | — | — | 1 | 3 |
Liver failure | D017093 | HP_0001399 | K72.9 | 1 | 1 | — | — | 1 | 2 |
Liver transplantation | D016031 | EFO_0010682 | — | 1 | 1 | — | — | 1 | 2 |
Hepatic insufficiency | D048550 | — | — | 1 | 1 | — | — | — | 1 |
Hepatitis c | D006526 | — | B19.2 | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Drug interactions | D004347 | — | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 2 | 2 |
Portal hypertension | D006975 | EFO_0000666 | K76.6 | — | — | — | — | 2 | 2 |
Sustained virologic response | D000072230 | — | — | — | — | — | — | 1 | 1 |
Esophageal and gastric varices | D004932 | EFO_0009545 | I85 | — | — | — | — | 1 | 1 |
Acute liver failure | D017114 | HP_0004448 | — | — | — | — | — | 1 | 1 |
Cardiac surgical procedures | D006348 | — | — | — | — | — | — | 1 | 1 |
Drug common name | Adefovir dipivoxil |
INN | — |
Description | Adefovir is a member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection. It has a role as a HIV-1 reverse transcriptase inhibitor, a drug metabolite, an antiviral drug, a nephrotoxic agent and a DNA synthesis inhibitor. It is a member of 6-aminopurines, an ether and a member of phosphonic acids. It is functionally related to an adenine. It is a conjugate acid of an adefovir(1-). |
Classification | Small molecule |
Drug class | antivirals |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | CC(C)(C)C(=O)OCOP(=O)(COCCn1cnc2c(N)ncnc21)OCOC(=O)C(C)(C)C |