Hepcidin
Hepcidin is a protein pharmaceutical. It is currently being investigated in clinical studies.
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Clinical
Clinical Trials
97 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anemia | D000740 | HP_0001903 | D64.9 | 3 | 3 | 2 | 5 | 21 | 33 |
| Iron deficiencies | D000090463 | — | — | — | 1 | — | 2 | 26 | 29 |
| Iron-deficiency anemia | D018798 | HP_0001891 | D50 | — | 1 | — | 2 | 21 | 24 |
| Metabolic diseases | D008659 | EFO_0000589 | E88.9 | — | — | — | 1 | 5 | 6 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.9 | 1 | 2 | — | 1 | 2 | 5 |
| Vitamin d deficiency | D014808 | EFO_0003762 | E55 | — | — | — | 2 | 1 | 3 |
| Colorectal neoplasms | D015179 | — | — | — | — | — | 2 | — | 2 |
| Inflammatory bowel diseases | D015212 | EFO_0003767 | — | — | — | — | 1 | 1 | 2 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | — | — | 1 | 1 | 2 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | — | — | 1 | — | 1 |
Show 6 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Polycythemia vera | D011087 | — | D45 | — | 2 | 2 | — | — | 4 |
| Polycythemia | D011086 | EFO_0005804 | D75.1 | — | 2 | 2 | — | — | 4 |
| Critical care | D003422 | — | — | — | — | 1 | — | 1 | 2 |
| Essential thrombocythemia | D013920 | — | D47.3 | — | — | 1 | — | — | 1 |
| Primary myelofibrosis | D055728 | — | D47.4 | — | — | 1 | — | — | 1 |
| Thrombocytosis | D013922 | HP_0001894 | D75.83 | — | — | 1 | — | — | 1 |
| Postoperative hemorrhage | D019106 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic renal insufficiency | D051436 | — | N18 | 3 | 4 | — | — | 2 | 7 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 3 | 4 | — | — | 2 | 7 |
| Iron overload | D019190 | — | — | — | 2 | — | — | 4 | 6 |
| Chronic disease | D002908 | — | — | 2 | 1 | — | — | 2 | 5 |
| Thalassemia | D013789 | EFO_1001996 | D56 | — | 2 | — | — | 2 | 4 |
| Hemochromatosis | D006432 | EFO_1000642 | E83.11 | — | 2 | — | — | 1 | 3 |
| Hemosiderosis | D006486 | — | — | — | 2 | — | — | 1 | 3 |
| Beta-thalassemia | D017086 | Orphanet_848 | D56.1 | — | 2 | — | — | 1 | 3 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | 1 | — | — | 1 | 2 |
| Disease | D004194 | EFO_0000408 | R69 | — | 1 | — | — | — | 1 |
Show 3 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Inflammation | D007249 | MP_0001845 | — | 1 | — | — | — | 9 | 10 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | 1 | 2 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Iron metabolism disorders | D019189 | — | E83.1 | — | — | — | — | 6 | 6 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 4 | 4 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | — | — | — | 4 | 4 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | — | — | — | 3 | 3 |
| Hepatitis c | D006526 | — | B19.2 | — | — | — | — | 2 | 2 |
| Hepatitis | D006505 | HP_0012115 | K75.9 | — | — | — | — | 2 | 2 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | — | — | — | — | 2 | 2 |
| Fibrosis | D005355 | — | — | — | — | — | — | 2 | 2 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | — | — | — | — | 2 | 2 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Hepcidin |
| INN | hepcidin |
| Description | Hepcidin is a protein that in humans is encoded by the HAMP gene. Hepcidin is a key regulator of the entry of iron into the circulation in mammals.
|
| Classification | Protein |
| Drug class | natural antibiotics (undefined group) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >3H0T:A|Fab fragment, Light chain
NFMLTQPHSVSESPGKTVTISCTRSSGSIASYYVQWYQQRPGSSPTTVIYEDSQRPSGVPDRFSGSIDSSSNSASLTISG
LKTEDEADYYCQSYDSSNVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVK
AGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
>3H0T:B|Fab fragment, Heavy chain
QVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWNWIRQSPSRGLEWLGRTYYRSKWFNDYAVSVQSRITINPDTSKN
QFSLQLNSVTPEDTAVYYCARGIVFSYAMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT
VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCAADEVDHHHHHH |
Target
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Variants
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Financial
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Trends
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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