Haloperidol
Haldol, Haloperidol (haloperidol) is a small molecule pharmaceutical. Haloperidol was first approved as Haldol on 1982-01-01. It is used to treat child behavior disorders, psychotic disorders, schizophrenia, schizophrenia spectrum and other psychotic disorders, and substance withdrawal syndrome amongst others in the USA. The pharmaceutical is active against D(3) dopamine receptor, D(4) dopamine receptor, 5-hydroxytryptamine receptor 2A, and D(2) dopamine receptor. In addition, it is known to target D(1A) dopamine receptor, G protein-activated inward rectifier potassium channel 2, D(1B) dopamine receptor, 5-hydroxytryptamine receptor 7, voltage-gated delayed rectifier potassium channel KCNH1; potassium voltage-gated channel subfamily H member 1, 5-hydroxytryptamine receptor 1D, 5-hydroxytryptamine receptor 2B, histamine H1 receptor, and 5-hydroxytryptamine receptor 1A.
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Commercial
Trade Name
FDA
EMA
Haloperidol (discontinued: Haldol, Haloperidol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Haloperidol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| HALDOL | Johnson & Johnson | N-015921 DISCN | 1982-01-01 | 6 products, RLD |
| HALDOL SOLUTAB | Johnson & Johnson | N-017079 DISCN | 1982-01-01 | 1 products |
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Haloperidol lactate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| HALDOL | Johnson & Johnson | N-015923 DISCN | 1982-01-01 | 1 products, RLD |
| HALDOL | Johnson & Johnson | N-015922 DISCN | 1982-01-01 | 1 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| haldol decanoate | New Drug Application | 2025-01-30 |
| haloperidol | ANDA | 2025-10-01 |
| haloperidol decanoate | ANDA | 2025-09-30 |
| haloperidol lactate | ANDA | 2024-12-30 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
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Clinical
Clinical Trials
198 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 1 | 1 | 2 | 2 | 6 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Psychotic disorders | D011618 | — | F20.81 | — | — | 1 | — | 1 | 2 |
| Mania | D000087122 | — | F30 | — | — | 2 | — | — | 2 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | 2 | — | — | 2 |
| Disease progression | D018450 | — | — | — | — | 1 | — | — | 1 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | — | 1 | — | — | 1 |
| Vascular dementia | D015140 | — | F01 | — | — | 1 | — | — | 1 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | — | 1 | — | — | 1 |
| Dementia | D003704 | EFO_0003862 | F03 | — | — | 1 | — | — | 1 |
| Problem behavior | D000066553 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
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Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 1 | 1 |
| Aggression | D000374 | EFO_0003015 | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Haloperidol |
| INN | haloperidol |
| Description | Haloperidol is a compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety. It has a role as a serotonergic antagonist, a first generation antipsychotic, a dopaminergic antagonist, an antidyskinesia agent and an antiemetic. It is a hydroxypiperidine, an organofluorine compound, an aromatic ketone, a tertiary alcohol and a member of monochlorobenzenes. |
| Classification | Small molecule |
| Drug class | antipsychotics (haloperidol type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 52-86-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL54 |
| ChEBI ID | 5613 |
| PubChem CID | 3559 |
| DrugBank | DB00502 |
| UNII ID | J6292F8L3D (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
KCNH1
KCNH1
Organism
Homo sapiens
Gene name
KCNH1
Gene synonyms
EAG, EAG1
NCBI Gene ID
Protein name
potassium voltage-gated channel subfamily H member 1
Protein synonyms
EAG channel 1, ether-a-go-go 1, Ether-a-go-go potassium channel 1, ether-a-go-go, Drosophila, homolog of, h-eag, hEAG1, potassium channel, voltage gated eag related subfamily H, member 1, potassium voltage-gated channel, subfamily H (eag-related), member 1, Voltage-gated potassium channel subunit Kv10.1
Uniprot ID
Mouse ortholog
Kcnh1 (16510)
potassium voltage-gated channel subfamily H member 1 (Q60603)
Variants
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Financial
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Estimated US medical usage
Haloperidol
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Trends
PubMed Central
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Additional graphs summarizing 42,805 documents
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Safety
Black-box Warning
Black-box warning for: Haldol decanoate, Haloperidol, Haloperidol decanoate, Haloperidol lactate
Adverse Events
Top Adverse Reactions
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27,764 adverse events reported
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