Haloperidol
Haldol, Haloperidol (haloperidol) is a small molecule pharmaceutical. Haloperidol was first approved as Haldol on 1982-01-01. It is used to treat child behavior disorders, psychotic disorders, schizophrenia, schizophrenia spectrum and other psychotic disorders, and substance withdrawal syndrome amongst others in the USA. The pharmaceutical is active against D(3) dopamine receptor, D(4) dopamine receptor, 5-hydroxytryptamine receptor 2A, and D(2) dopamine receptor. In addition, it is known to target D(1A) dopamine receptor, G protein-activated inward rectifier potassium channel 2, D(1B) dopamine receptor, 5-hydroxytryptamine receptor 7, voltage-gated delayed rectifier potassium channel KCNH1; potassium voltage-gated channel subfamily H member 1, 5-hydroxytryptamine receptor 1D, 5-hydroxytryptamine receptor 2B, histamine H1 receptor, and 5-hydroxytryptamine receptor 1A.
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Commercial
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Haloperidol (discontinued: Haldol, Haloperidol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Haloperidol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| HALDOL | Johnson & Johnson | N-015921 DISCN | 1982-01-01 | 6 products, RLD |
| HALDOL SOLUTAB | Johnson & Johnson | N-017079 DISCN | 1982-01-01 | 1 products |
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Haloperidol lactate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| HALDOL | Johnson & Johnson | N-015923 DISCN | 1982-01-01 | 1 products, RLD |
| HALDOL | Johnson & Johnson | N-015922 DISCN | 1982-01-01 | 1 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| haloperidol | ANDA | 2026-08-31 |
| haloperidol decanoate | ANDA | 2026-09-21 |
| haloperidol lactate | ANDA | 2026-07-14 |
Indications
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Agency Specific
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Clinical
Clinical Trials
200 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schizophrenia | D012559 | EFO_0000692 | F20 | 1 | 5 | 12 | 24 | 18 | 58 |
| Delirium | D003693 | — | R41.0 | — | 9 | 17 | 10 | 8 | 40 |
| Psychotic disorders | D011618 | — | F20.81 | 1 | 2 | 11 | 11 | 4 | 28 |
| Psychomotor agitation | D011595 | — | — | — | 2 | 8 | 10 | 7 | 26 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | 2 | 7 | 4 | 2 | 14 |
| Vomiting | D014839 | — | R11.1 | 1 | — | 3 | 5 | 4 | 13 |
| Nausea | D009325 | — | R11.0 | 1 | — | 1 | 5 | 4 | 11 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | 1 | 4 | 1 | 3 | 9 |
| Neoplasms | D009369 | — | C80 | — | 3 | 4 | 1 | 1 | 7 |
| Emergencies | D004630 | — | — | — | 1 | 1 | 4 | 1 | 7 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Recurrence | D012008 | — | — | — | 3 | 2 | — | 1 | 4 |
| Critical illness | D016638 | — | — | — | 1 | 1 | — | 2 | 4 |
| Hyperkinesis | D006948 | — | — | — | — | 2 | — | 1 | 3 |
| Anesthesia | D000758 | — | — | — | — | 1 | — | 1 | 2 |
| Dementia | D003704 | EFO_0003862 | F03 | — | — | 2 | — | — | 2 |
| Medication adherence | D055118 | EFO_0006344 | — | — | — | 1 | — | 1 | 2 |
| Hypokinesia | D018476 | — | — | — | — | 2 | — | — | 2 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | 1 | 1 | — | 1 | 2 |
| Heart arrest | D006323 | EFO_0009492 | I46 | — | — | 1 | — | 1 | 2 |
| Intellectual disability | D008607 | EFO_0003847 | F73 | — | 1 | 1 | — | — | 2 |
Show 26 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Artificial respiration | D012121 | — | — | — | 1 | — | — | 1 | 2 |
| Movement disorders | D009069 | EFO_0004280 | G25 | — | 1 | — | — | 1 | 2 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | 1 | — | — | — | 1 |
| Fallopian tube neoplasms | D005185 | — | — | 1 | 1 | — | — | — | 1 |
| Peritoneal neoplasms | D010534 | — | — | 1 | 1 | — | — | — | 1 |
| Intestinal obstruction | D007415 | — | K56.60 | 1 | 1 | — | — | — | 1 |
| Critical care | D003422 | — | — | — | 1 | — | — | — | 1 |
| Ventilator weaning | D015300 | — | — | — | 1 | — | — | — | 1 |
| Gambling | D005715 | EFO_1001926 | F63.0 | — | 1 | — | — | — | 1 |
| Drug overdose | D062787 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | 1 | 3 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | — | — | — | 1 | 2 |
| Therapeutic equivalency | D013810 | — | — | 2 | — | — | — | — | 2 |
| Placebos | D010919 | — | — | 1 | — | — | — | — | 1 |
| Body weight | D001835 | EFO_0004338 | — | 1 | — | — | — | — | 1 |
| Weight gain | D015430 | — | — | 1 | — | — | — | — | 1 |
| Pharmacogenomic testing | D000071185 | — | — | 1 | — | — | — | — | 1 |
| Huntington disease | D006816 | Orphanet_399 | G10 | 1 | — | — | — | — | 1 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | 1 | — | — | — | — | 1 |
| Tobacco use disorder | D014029 | — | F17 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Long qt syndrome | D008133 | HP_0001657 | I45.81 | — | — | — | — | 2 | 2 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | — | — | — | 2 | 2 |
| Dyslipidemias | D050171 | — | — | — | — | — | — | 2 | 2 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | — | — | — | — | 2 | 2 |
| Torsades de pointes | D016171 | EFO_0005307 | I47.21 | — | — | — | — | 1 | 1 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 1 | 1 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
| Drug interactions | D004347 | — | — | — | — | — | — | 1 | 1 |
| Female genital diseases | D005831 | EFO_0009549 | N85 | — | — | — | — | 1 | 1 |
| Sleep deprivation | D012892 | — | F51.12 | — | — | — | — | 1 | 1 |
Show 66 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Haloperidol |
| INN | haloperidol |
| Description | Haloperidol is a compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety. It has a role as a serotonergic antagonist, a first generation antipsychotic, a dopaminergic antagonist, an antidyskinesia agent and an antiemetic. It is a hydroxypiperidine, an organofluorine compound, an aromatic ketone, a tertiary alcohol and a member of monochlorobenzenes. |
| Classification | Small molecule |
| Drug class | antipsychotics (haloperidol type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 52-86-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL54 |
| ChEBI ID | 5613 |
| PubChem CID | 3559 |
| DrugBank | DB00502 |
| UNII ID | J6292F8L3D (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
KCNH1
KCNH1
Organism
Homo sapiens
Gene name
KCNH1
Gene synonyms
EAG, EAG1
NCBI Gene ID
Protein name
potassium voltage-gated channel subfamily H member 1
Protein synonyms
EAG channel 1, ether-a-go-go 1, Ether-a-go-go potassium channel 1, ether-a-go-go, Drosophila, homolog of, h-eag, hEAG1, potassium channel, voltage gated eag related subfamily H, member 1, potassium voltage-gated channel, subfamily H (eag-related), member 1, Voltage-gated potassium channel subunit Kv10.1
Uniprot ID
Mouse ortholog
Kcnh1 (16510)
potassium voltage-gated channel subfamily H member 1 (Q60603)
Variants
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Financial
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Haloperidol
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Trends
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Safety
Black-box Warning
Black-box warning for: Haloperidol, Haloperidol decanoate, Haloperidol lactate
Adverse Events
Top Adverse Reactions
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28,680 adverse events reported
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