Gramicidin
/ /, Neosporin (gramicidin) is an unknown pharmaceutical. Gramicidin was first approved as Neo-polycin on 1982-01-01. It is used to treat bacterial eye infections and gram-positive bacterial infections in the USA.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Combinations
Neomycin polymyxin b sulfates gramicidin, Neosporin (discontinued: Neo-polycin, Neomycin polymyxin b sulfates gramicidin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name
Status
Last Update
neomycin and polymyxin b sulfates and gramicidinANDA2024-09-18
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
R02: Throat preparations
R02A: Throat preparations
R02AB: Antibiotic throat preparations
R02AB30: Gramicidin
HCPCS
No data
Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Corneal ulcerD003320H16.011
HordeolumD006726EFO_0007315H00.0111
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PharyngitisD010612R07.0213
NasopharyngitisD009304J0011
Pharyngeal diseasesD01060811
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SepsisD018805EFO_0001420A41.911
InfectionsD007239EFO_000054411
Communicable diseasesD00314111
Infectious skin diseasesD01287411
Skin diseasesD012871L00-L9911
BlindnessD001766H53.1211
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameGramicidin
INNgramicidin s
Description
Gramicidin, also called gramicidin D, is a mix of ionophoric antibiotics, gramicidin A, B and C, which make up about 80%, 5%, and 15% of the mix, respectively. Each has 2 isoforms, so the mix has 6 different types of gramicidin molecules. They can be extracted from Brevibacillus brevis soil bacteria. Gramicidins are linear peptides with 15 amino acids. This is in contrast to unrelated gramicidin S, which is a cyclic peptide.
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Classification
Unknown
Drug classnatural antibiotics (undefined group)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Identifiers
PDB
CAS-ID1405-97-6
RxCUI
ChEMBL IDCHEMBL1201469
ChEBI ID
PubChem CID45267103
DrugBankDB00027
UNII ID5IE62321P4 (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
£
No data
Estimated US medical usage
Gramicidin
+
Neomycin
+
Polymyxin b
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 10,010 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,120 adverse events reported
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