Gramicidin
/ /, Neosporin (gramicidin) is an unknown pharmaceutical. Gramicidin was first approved as Neo-polycin on 1982-01-01. It is used to treat bacterial eye infections and gram-positive bacterial infections in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| eye diseases | D005128 |
Trade Name
FDA
EMA
Combinations
Neomycin polymyxin b sulfates gramicidin, Neosporin (discontinued: Neo-polycin, Neomycin polymyxin b sulfates gramicidin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| neomycin and polymyxin b sulfates and gramicidin | ANDA | 2026-02-04 |
Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
10 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Corneal ulcer | D003320 | — | H16.0 | — | — | 1 | — | — | 1 |
| Hordeolum | D006726 | EFO_0007315 | H00.01 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharyngitis | D010612 | — | R07.0 | 2 | 1 | — | — | — | 3 |
| Oral lichen planus | D017676 | — | — | — | 1 | — | — | — | 1 |
| Lichen planus | D008010 | — | L43 | — | 1 | — | — | — | 1 |
| Nasopharyngitis | D009304 | — | J00 | — | 1 | — | — | — | 1 |
| Pharyngeal diseases | D010608 | — | — | — | 1 | — | — | — | 1 |
| Aphthous stomatitis | D013281 | EFO_0003938 | K12.0 | — | 1 | — | — | — | 1 |
| Oral ulcer | D019226 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 1 | — | — | — | 1 | 2 |
| Communicable diseases | D003141 | — | — | 1 | — | — | — | 1 | 2 |
| Wounds and injuries | D014947 | — | T14.8 | 1 | — | — | — | — | 1 |
| Wound infection | D014946 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sepsis | D018805 | EFO_0001420 | A41.9 | — | — | — | — | 1 | 1 |
| Infectious skin diseases | D012874 | — | — | — | — | — | — | 1 | 1 |
| Skin diseases | D012871 | — | L00-L99 | — | — | — | — | 1 | 1 |
| Blindness | D001766 | — | H53.12 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Gramicidin |
| INN | gramicidin s |
| Description | Gramicidin, also called gramicidin D, is a mix of ionophoric antibiotics, gramicidin A, B and C, which make up about 80%, 5%, and 15% of the mix, respectively. Each has 2 isoforms, so the mix has 6 different types of gramicidin molecules. They can be extracted from Brevibacillus brevis soil bacteria. Gramicidins are linear peptides with 15 amino acids. This is in contrast to unrelated gramicidin S, which is a cyclic peptide.
|
| Classification | Unknown |
| Drug class | natural antibiotics (undefined group) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 1405-97-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201469 |
| ChEBI ID | — |
| PubChem CID | 45267103 |
| DrugBank | DB00027 |
| UNII ID | 5IE62321P4 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
Revenue by drug
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Estimated US medical usage
Gramicidin
+
Neomycin
+
Polymyxin b
Total medical expenditures per year (USD, in millions)
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Number of purchases
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,754 adverse events reported
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