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Drug ReportsGlucagon
Glucagon, Baqsimi(glucagon)
Baqsimi, Glucagon, Gvoke, Ogluo (glucagon) is a protein pharmaceutical. Glucagon was first approved as Glucagon on 1982-01-01. It is used to treat anaphylaxis, bradycardia, cardiogenic shock, hypoglycemia, and hypotension in the USA. It has been approved in Europe to treat diabetes mellitus. The pharmaceutical is active against glucagon receptor. In addition, it is known to target glucagon-like peptide 2 receptor and glucagon-like peptide 1 receptor.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
nutritional and metabolic diseasesD009750
endocrine system diseasesD004700
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Baqsimi, Glucagon, Gvoke vialdx (discontinued: Glucagen, Glucagon, Gvoke vialdx)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Glucagon hydrochloride
Tradename
Company
Number
Date
Products
GLUCAGONFresenius KabiN-201849 RX2015-05-08
2 products, RLD, RS
Show 2 discontinued
Glucagon
Tradename
Company
Number
Date
Products
BAQSIMIAmphastar PharmaceuticalsN-210134 RX2019-07-24
1 products, RLD, RS
GVOKE PFSXeris PharmaceuticalsN-212097 RX2019-09-10
1 products, RLD, RS
GVOKE HYPOPENXeris PharmaceuticalsN-212097 RX2019-09-10
2 products, RLD, RS
GVOKE KITXeris PharmaceuticalsN-212097 RX2021-08-20
1 products, RLD, RS
GVOKE VIALDXXeris PharmaceuticalsN-212097 RX2025-03-14
1 products, RLD, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
baqsimiNew Drug Application2025-08-06
glucag0nNew Drug Application2022-12-09
glucagonANDA2025-08-04
glucagon glucagonNew Drug Application2019-05-22
gvoke hypopen gvoke kit gvoke pfsNew Drug Application2023-01-10
gvoke hypopen gvoke pfsNew Drug Application2021-07-15
gvoke hypopen gvoke kit gvoke pfsNew Drug Application2025-05-27
gvoke hypopen gvoke pfsNew Drug Application2019-09-10
gvoke vialdxNew Drug Application2025-03-01
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hypotensionEFO_0005251D007022I95
cardiogenic shock—D012770R57.0
anaphylaxis—D000707T78.2
hypoglycemia—D007003E16.2
bradycardia—D001919R00.1
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Glucagon, Baqsimi, Amphastar Pharms Inc
107656022039-09-23DP
108941332038-01-03DP
102134872036-02-16DPU-2604
Glucagon, Gvoke Hypopen, Xeris
96493642036-04-22DPU-2742
115902052036-04-22DPU-2742
ATC Codes
A: Alimentary tract and metabolism drugs
— A10: Drugs used in diabetes
— A10B: Blood glucose lowering drugs, excl. insulins
— A10BJ: Glucagon-like peptide-1 (glp-1) analogues
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H04: Pancreatic hormones
— H04A: Glycogenolytic hormones
— H04AA: Glycogenolytic hormones
— H04AA01: Glucagon
HCPCS
Code
Description
J1610
Injection, glucagon hydrochloride, per 1 mg
J1611
Injection, glucagon hydrochloride (fresenius kabi), not therapeutically equivalent to j1610, per 1 mg
Clinical
Clinical Trials
1308 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Type 2 diabetes mellitusD003924EFO_0001360E11116198549
ObesityD009765EFO_0001073E66.9810204—42
Diabetes mellitusD003920EFO_0000400E08-E13105173236
OverweightD050177—E66.368152—31
Metabolic diseasesD008659EFO_0000589E88.9——31—4
Metabolic syndromeD024821EFO_0000195E88.810——21—3
Body weightD001835EFO_0004338———21—3
Coronary artery diseaseD003324—I25.1——11—2
Psoriatic arthritisD015535EFO_0003778L40.5——11—2
ArthritisD001168EFO_0005856M05-M14——11—2
Show 5 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Type 1 diabetes mellitusD003922EFO_0001359E10514——9
HypoglycemiaD007003—E16.2323——7
Glucose metabolism disordersD044882————3——3
Endocrine system diseasesD004700EFO_0001379E34.9——3——3
Weight lossD015431————2—13
Non-alcoholic fatty liver diseaseD065626EFO_0003095K75.81—11——2
Fatty liverD005234EFO_0003934——11——2
Left ventricular dysfunctionD018487————1——1
Heart failureD006333EFO_0003144I50——1——1
Nutrition disordersD009748EFO_0001069———1——1
Show 9 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HyperglycemiaD006943—R73.911———1
Chronic renal insufficiencyD051436—N18—1———1
Kidney diseasesD007674EFO_0003086N08—1———1
BulimiaD002032—F50.2—1———1
Feeding and eating disordersD001068—F50—1———1
Binge-eating disorderD056912—F50.2—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———14————14
Common coldD003139EFO_0007214J001————1
Liver failureD017093—K72.91————1
Hepatic insufficiencyD048550——1————1
Chronic kidney failureD007676EFO_0003884N18.61————1
Renal insufficiencyD051437—N191————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
CarcinomaD002277—C80.0————11
Thyroid neoplasmsD013964EFO_0003841—————11
Neuroendocrine carcinomaD018278——————11
Papillary thyroid cancerD000077273——————11
Thyroid diseasesD013959—E00-E07————11
Diabetic nephropathiesD003928EFO_0000401—————11
InflammationD007249MP_0001845—————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameGlucagon
INNglucagon
Description
Glucagon is a 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence.
Classification
Protein
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)O)[C@@H](C)O
Identifiers
PDB—
CAS-ID9007-92-5
RxCUI—
ChEMBL IDCHEMBL266481
ChEBI ID5391
PubChem CID16132283
DrugBankDB00040
UNII ID76LA80IG2G (ChemIDplus, GSRS)
Target
Agency Approved
GCGR
GCGR
Organism
Homo sapiens
Gene name
GCGR
Gene synonyms
NCBI Gene ID
2642
Protein name
glucagon receptor
Protein synonyms
Uniprot ID
Q2M3M5
Mouse ortholog
Gcgr (14527)
glucagon receptor (Q8K0B5)
Alternate
GLP2R
GLP2R
GLP1R
GLP1R
Organism
Homo sapiens
Gene name
GLP2R
Gene synonyms
NCBI Gene ID
9340
Protein name
glucagon-like peptide 2 receptor
Protein synonyms
epididymis secretory sperm binding protein, GLP-2 receptor
Uniprot ID
Q4VAT3
Mouse ortholog
Glp2r (93896)
glucagon-like peptide 2 receptor (Q5SU65)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Baqsimi – Eli Lilly
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Baqsimi – Amphastar Pharmaceuticals
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Glucagon – Amphastar Pharmaceuticals
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Gvoke – Xeris Biopharma Holdings
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Estimated US medical usage
Glucagon
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 4,970 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,893 adverse events reported
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