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Drug ReportsGlucagon
Glucagon, Baqsimi(glucagon)
Baqsimi, Glucagon, Gvoke, Ogluo (glucagon) is a protein pharmaceutical. Glucagon was first approved as Glucagon on 1982-01-01. It is used to treat anaphylaxis, bradycardia, cardiogenic shock, hypoglycemia, and hypotension in the USA. It has been approved in Europe to treat diabetes mellitus. The pharmaceutical is active against glucagon receptor. In addition, it is known to target glucagon-like peptide 2 receptor and glucagon-like peptide 1 receptor.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
nutritional and metabolic diseasesD009750
endocrine system diseasesD004700
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Baqsimi, Glucagon, Gvoke vialdx (discontinued: Glucagen, Glucagon, Gvoke vialdx)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Glucagon hydrochloride
Tradename
Company
Number
Date
Products
GLUCAGONFresenius KabiN-201849 RX2015-05-08
2 products, RLD, RS
Show 2 discontinued
Glucagon
Tradename
Company
Number
Date
Products
BAQSIMIAmphastar PharmaceuticalsN-210134 RX2019-07-24
1 products, RLD, RS
GVOKE PFSXeris PharmaceuticalsN-212097 RX2019-09-10
1 products, RLD, RS
GVOKE HYPOPENXeris PharmaceuticalsN-212097 RX2019-09-10
2 products, RLD, RS
GVOKE KITXeris PharmaceuticalsN-212097 RX2021-08-20
1 products, RLD, RS
GVOKE VIALDXXeris PharmaceuticalsN-212097 RX2025-03-14
1 products, RLD, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
baqsimiNew Drug Application2024-11-13
glucag0nNew Drug Application2022-12-09
glucagonNew Drug Application2025-03-31
glucagon glucagonNew Drug Application2019-05-22
gvoke hypopen gvoke kit gvoke pfsNew Drug Application2023-01-10
gvoke hypopen gvoke pfsNew Drug Application2021-07-15
gvoke hypopen gvoke kit gvoke pfsNew Drug Application2025-03-26
gvoke hypopen gvoke pfsNew Drug Application2019-09-10
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hypotensionEFO_0005251D007022I95
cardiogenic shock—D012770R57.0
anaphylaxis—D000707T78.2
hypoglycemia—D007003E16.2
bradycardia—D001919R00.1
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Glucagon, Baqsimi, Amphastar Pharms Inc
107656022039-09-23DP
108941332038-01-03DP
102134872036-02-16DPU-2604
Glucagon, Gvoke Hypopen, Xeris
96493642036-04-22DPU-2742
115902052036-04-22DPU-2742
ATC Codes
A: Alimentary tract and metabolism drugs
— A10: Drugs used in diabetes
— A10B: Blood glucose lowering drugs, excl. insulins
— A10BJ: Glucagon-like peptide-1 (glp-1) analogues
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H04: Pancreatic hormones
— H04A: Glycogenolytic hormones
— H04AA: Glycogenolytic hormones
— H04AA01: Glucagon
HCPCS
Code
Description
J1610
Injection, glucagon hydrochloride, per 1 mg
J1611
Injection, glucagon hydrochloride (fresenius kabi), not therapeutically equivalent to j1610, per 1 mg
Clinical
Clinical Trials
1917 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Diabetes mellitusD003920EFO_0000400E08-E13155143265138208877
Type 2 diabetes mellitusD003924EFO_0001360E11156100251169209866
ObesityD009765EFO_0001073E66.95656806867315
Type 1 diabetes mellitusD003922EFO_0001359E104474411865217
Healthy volunteers/patients———8457920123
OverweightD050177—E66.32622342317121
HypoglycemiaD007003—E16.223241883299
Fatty liverD005234EFO_0003934—8175161760
Weight lossD015431——2815171455
Non-alcoholic fatty liver diseaseD065626EFO_0003095K75.819195111454
Show 128 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Nutrition disordersD009748EFO_0001069—11210—124
HyperinsulinismD006946—E16.1753—516
Congenital hyperinsulinismD044903——663—415
NesidioblastosisD046768EFO_0007318E16.9663—415
StrokeD020521EFO_0000712I63.9—51—410
Alcoholic fatty liverD005235—K70.0351—210
Cystic fibrosisD003550EFO_0000390E84121—47
Parkinson diseaseD010300EFO_0002508G20151——7
Alzheimer diseaseD000544EFO_0000249F03—33—17
Endocrine system diseasesD004700EFO_0001379E34.91—2—36
Show 33 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AlcoholismD000437EFO_0003829F10.127——110
InsulinomaD007340——51——49
Alcohol drinkingD000428EFO_0004329——5——16
Smoking cessationD016540EFO_0004319—24———5
IschemiaD007511EFO_0000556——3——25
Cocaine-related disordersD019970—F1432———4
Digestive system diseasesD004066EFO_0000405K92.931———4
Exocrine pancreatic insufficiencyD010188—K86.81—1——23
Cerebral infarctionD002544—I63—2——13
Opioid-related disordersD009293EFO_0005611F1113———3
Show 63 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
GlucagonomaD005935——1———45
Physiological phenomenaD010829——1———12
Gastrointestinal diseasesD005767——2————2
Therapeutic equivalencyD013810——2————2
Carcinoid tumorD002276—D3A.001————1
Alcoholic intoxicationD000435——1————1
PintaD010874EFO_1001396A671————1
Common coldD003139EFO_0007214J001————1
Taste disordersD013651——1————1
Hormone replacement therapyD020249EFO_0003961Z79.8901————1
Show 11 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369—C80————55
Stomach neoplasmsD013274EFO_0003897C16————44
Respiratory aspiration of gastric contentsD063466——————44
Esophageal neoplasmsD004938—C15————33
MalnutritionD044342EFO_0008572E40-E46————33
GastroparesisD018589EFO_1000948K31.84————33
PancreatitisD010195EFO_0000278K85————22
Metabolically benign obesityD000067329——————22
Pituitary dwarfismD004393EFO_1001109E23.0————22
Blood circulationD001775——————22
Show 69 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameGlucagon
INNglucagon
Description
Glucagon is a 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence.
Classification
Protein
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)O)[C@@H](C)O
Identifiers
PDB—
CAS-ID9007-92-5
RxCUI—
ChEMBL IDCHEMBL266481
ChEBI ID5391
PubChem CID16132283
DrugBankDB00040
UNII ID76LA80IG2G (ChemIDplus, GSRS)
Target
Agency Approved
GCGR
GCGR
Organism
Homo sapiens
Gene name
GCGR
Gene synonyms
NCBI Gene ID
2642
Protein name
glucagon receptor
Protein synonyms
Uniprot ID
Q2M3M5
Mouse ortholog
Gcgr (14527)
glucagon receptor (Q8K0B5)
Alternate
GLP2R
GLP2R
GLP1R
GLP1R
Organism
Homo sapiens
Gene name
GLP2R
Gene synonyms
NCBI Gene ID
9340
Protein name
glucagon-like peptide 2 receptor
Protein synonyms
epididymis secretory sperm binding protein, GLP-2 receptor
Uniprot ID
Q4VAT3
Mouse ortholog
Glp2r (93896)
glucagon-like peptide 2 receptor (Q5SU65)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Glucagon – Amphastar Pharmaceuticals
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Gvoke – Xeris Biopharma Holdings
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Baqsimi – Eli Lilly
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Baqsimi – Amphastar Pharmaceuticals
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Estimated US medical usage
Glucagon
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 45 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,664 adverse events reported
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