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Drug ReportsGlucagon
Glucagon, Baqsimi(glucagon)
Baqsimi, Glucagon, Gvoke, Ogluo (glucagon) is a protein pharmaceutical. Glucagon was first approved as Glucagon on 1982-01-01. It is used to treat anaphylaxis, bradycardia, cardiogenic shock, hypoglycemia, and hypotension in the USA. It has been approved in Europe to treat diabetes mellitus. The pharmaceutical is active against glucagon receptor. In addition, it is known to target glucagon-like peptide 2 receptor and glucagon-like peptide 1 receptor.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
nutritional and metabolic diseasesD009750
endocrine system diseasesD004700
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Baqsimi, Glucagon, Gvoke (discontinued: Glucagen, Glucagon, Gvoke)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Glucagon hydrochloride
Tradename
Company
Number
Date
Products
GLUCAGONFresenius KabiN-201849 RX2015-05-08
2 products, RLD, RS
Show 2 discontinued
Glucagon
Tradename
Company
Number
Date
Products
BAQSIMIAmphastar PharmaceuticalsN-210134 RX2019-07-24
1 products, RLD, RS
GVOKE PFSXeris PharmaceuticalsN-212097 RX2019-09-10
1 products, RLD, RS
GVOKE HYPOPENXeris PharmaceuticalsN-212097 RX2019-09-10
2 products, RLD, RS
GVOKE KITXeris PharmaceuticalsN-212097 RX2021-08-20
1 products, RLD, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
baqsimiNew Drug Application2024-11-13
glucag0nNew Drug Application2022-12-09
glucagen 10-pack glucagen diagnostic kit glucagen hypokit2008-08-21
glucagen hypokitNew Drug Application2021-03-19
glucagonNew Drug Application2024-02-22
glucagon glucagonNew Drug Application2019-05-22
gvoke hypopen gvoke kit gvoke pfsNew Drug Application2023-01-10
gvoke hypopen gvoke pfsNew Drug Application2021-07-15
gvoke hypopen gvoke kit gvoke pfsNew Drug Application2025-03-26
gvoke hypopen gvoke pfsNew Drug Application2019-09-10
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Glucagon, Baqsimi, Amphastar Pharms Inc
107656022039-09-23DP
108941332038-01-03DP
102134872036-02-16DPU-2604
Glucagon, Gvoke Hypopen, Xeris
96493642036-04-22DPU-2742
115902052036-04-22DPU-2742
ATC Codes
A: Alimentary tract and metabolism drugs
A10: Drugs used in diabetes
A10B: Blood glucose lowering drugs, excl. insulins
A10BJ: Glucagon-like peptide-1 (glp-1) analogues
H: Systemic hormonal preparations, excl. sex hormones and insulins
H04: Pancreatic hormones
H04A: Glycogenolytic hormones
H04AA: Glycogenolytic hormones
H04AA01: Glucagon
HCPCS
Code
Description
J1610
Injection, glucagon hydrochloride, per 1 mg
J1611
Injection, glucagon hydrochloride (fresenius kabi), not therapeutically equivalent to j1610, per 1 mg
Clinical
Clinical Trials
1903 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Type 2 diabetes mellitusD003924EFO_0001360E112720621312129
Diabetes mellitusD003920EFO_0000400E08-E13201964109117
ObesityD009765EFO_0001073E66.9131218
Fatty liverD005234EFO_0003934112
Body weightD001835EFO_0004338112
Weight gainD015430112
Glucose intoleranceD018149HP_0000833R73.0322
Non-alcoholic fatty liver diseaseD065626EFO_0003095K75.8111
Knee osteoarthritisD020370EFO_0004616M1711
OsteoarthritisD010003EFO_0002506M15-M1911
Indications Phases 3
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Liver diseasesD008107EFO_0001421K70-K7711
Diabetes complicationsD04890911
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients12113
Common coldD003139EFO_0007214J0011
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
CarcinomaD002277C80.011
Thyroid neoplasmsD013964EFO_000384111
Neuroendocrine carcinomaD01827811
Papillary thyroid cancerD00007727311
Thyroid diseasesD013959E00-E0711
Diabetic nephropathiesD003928EFO_000040111
InflammationD007249MP_000184511
PancreatitisD010195EFO_0000278K8511
HyperlipidemiasD006949EFO_0003774E78.511
Peripheral nervous system diseasesD010523G6411
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameGlucagon
INNglucagon
Description
Glucagon is a 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence.
Classification
Protein
Drug class
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)O)[C@@H](C)O
Identifiers
PDB
CAS-ID9007-92-5
RxCUI
ChEMBL IDCHEMBL266481
ChEBI ID5391
PubChem CID16132283
DrugBankDB00040
UNII ID76LA80IG2G (ChemIDplus, GSRS)
Target
Agency Approved
GCGR
GCGR
Organism
Homo sapiens
Gene name
GCGR
Gene synonyms
NCBI Gene ID
Protein name
glucagon receptor
Protein synonyms
Uniprot ID
Mouse ortholog
Gcgr (14527)
glucagon receptor (Q8K0B5)
Alternate
GLP2R
GLP2R
GLP1R
GLP1R
Organism
Homo sapiens
Gene name
GLP2R
Gene synonyms
NCBI Gene ID
Protein name
glucagon-like peptide 2 receptor
Protein synonyms
epididymis secretory sperm binding protein, GLP-2 receptor
Uniprot ID
Mouse ortholog
Glp2r (93896)
glucagon-like peptide 2 receptor (Q5SU65)
Variants
No data
Financial
Revenue by drug
$
£
Gvoke Xeris Biopharma Holdings
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Baqsimi Eli Lilly
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Baqsimi Amphastar Pharmaceuticals
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Glucagon Amphastar Pharmaceuticals
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Tabular view
Estimated US medical usage
Glucagon
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 98,506 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,664 adverse events reported
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