Amaryl, Avaglim(glimepiride)
Avaglim, Avandaryl, Duetact, Glimepiride, Tandemact (glimepiride) is a small molecule pharmaceutical. Glimepiride was first approved as Amaryl on 1995-11-30. It is used to treat type 2 diabetes mellitus in the USA. It has been approved in Europe to treat type 2 diabetes mellitus.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nutritional and metabolic diseases | D009750 |
| endocrine system diseases | D004700 |
Trade Name
FDA
EMA
Glimepiride (discontinued: Amaryl, Glimepiride)
CombinationsDuetact, Pioglitazone glimepiride (discontinued: Avandaryl, Rosiglitazone glimepiride)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Glimepiride
Glimepiride
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Pioglitazone hydrochloride
Glimepiride
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Rosiglitazone maleate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| AVANDARYL | SB Pharmco | N-021700 DISCN | 2005-11-23 | 5 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| duetact | New Drug Application | 2022-10-24 |
| glimepiride | ANDA | 2025-03-25 |
| glimepiride 3 mg | ANDA | 2024-08-20 |
| pioglitazone and glimepiride | NDA authorized generic | 2021-12-16 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| type 2 diabetes mellitus | EFO_0001360 | D003924 | E11 |
Agency Specific
FDA
EMA
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A10: Drugs used in diabetes
— A10B: Blood glucose lowering drugs, excl. insulins
— A10BB: Sulfonylureas for blood glucose lowering
— A10BB12: Glimepiride
— A10BD: Combinations of oral blood glucose lowering drugs
— A10BD04: Glimepiride and rosiglitazone
— A10BD06: Glimepiride and pioglitazone
HCPCS
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Clinical
Clinical Trials
270 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | 1 | — | — | 1 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | 1 | — | — | 1 |
Indications Phases 2
No data
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Glimepiride |
| INN | glimepiride |
| Description | Glimepiride is a sulfonamide, a N-acylurea and a N-sulfonylurea. It has a role as a hypoglycemic agent and an insulin secretagogue. |
| Classification | Small molecule |
| Drug class | antidiabetics |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCC1=C(C)CN(C(=O)NCCc2ccc(S(=O)(=O)NC(=O)N[C@H]3CC[C@H](C)CC3)cc2)C1=O |
Identifiers
| PDB | — |
| CAS-ID | 93479-97-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1481 |
| ChEBI ID | 5383 |
| PubChem CID | 3476 |
| DrugBank | DB00222 |
| UNII ID | 6KY687524K (ChemIDplus, GSRS) |
Target
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Variants
No data
Financial
Revenue by drug
$
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Estimated US medical usage
Glimepiride
Total medical expenditures per year (USD, in millions)
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Refill frequency
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Price per prescription (USD)
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Glimepiride
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Pioglitazone
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Glimepiride
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Rosiglitazone
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 8,331 documents
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Safety
Black-box Warning
Black-box warning for: Duetact, Pioglitazone and glimepiride
Adverse Events
Top Adverse Reactions
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10,391 adverse events reported
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