Glyburide
Diabeta, Glyburide, Glynase (glyburide) is a small molecule pharmaceutical. Glyburide was first approved as Micronase on 1984-05-01. It is used to treat type 2 diabetes mellitus in the USA. The pharmaceutical is active against ATP-sensitive inward rectifier potassium channel 11. In addition, it is known to target ATP-sensitive inward rectifier potassium channel 8, cystic fibrosis transmembrane conductance regulator, and solute carrier organic anion transporter family member 2B1.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nutritional and metabolic diseases | D009750 |
| endocrine system diseases | D004700 |
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| glucovance | New Drug Application | 2012-04-23 |
| glyburase | 2006-09-19 | |
| glyburide | ANDA | 2024-11-11 |
| glyburide and metformin | ANDA | 2011-12-20 |
| glyburide and metformin hydrochloride | ANDA | 2024-11-08 |
| glyburide-metformin hydrochloride | ANDA | 2024-10-21 |
Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
No data
HCPCS
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Clinical
Clinical Trials
138 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Glyburide |
| INN | glibenclamide |
| Description | Glyburide is an N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group. It has a role as a hypoglycemic agent, an anti-arrhythmia drug, an EC 2.7.1.33 (pantothenate kinase) inhibitor and an EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor. It is a N-sulfonylurea and a member of monochlorobenzenes. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 10238-21-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL472 |
| ChEBI ID | 5441 |
| PubChem CID | 3488 |
| DrugBank | DB01016 |
| UNII ID | SX6K58TVWC (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
SLCO2B1
SLCO2B1
AKR1C1
AKR1C1
Organism
Homo sapiens
Gene name
SLCO2B1
Gene synonyms
KIAA0880, OATP2B1, OATPB, SLC21A9
NCBI Gene ID
Protein name
solute carrier organic anion transporter family member 2B1
Protein synonyms
OATP-B, OATP-RP2, OATP2B1, OATPRP2, Organic anion transporter B, Organic anion transporter polypeptide-related protein 2, Organic anion transporting polypeptide 2B1, solute carrier family 21 (organic anion transporter), member 9, Solute carrier family 21 member 9
Uniprot ID
Mouse ortholog
Slco2b1 (101488)
solute carrier organic anion transporter family member 2B1 (Q8BXB6)
Variants
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Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 19,065 documents
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Safety
Black-box Warning
Black-box warning for: Glyburide and metformin hydrochloride, Glyburide-metformin hydrochloride
Adverse Events
Top Adverse Reactions
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6,693 adverse events reported
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