Gepotidacin
Gepotidacin is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
22 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | — | 2 | 4 | — | — | 6 |
| Communicable diseases | D003141 | — | — | — | 2 | 4 | — | — | 6 |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | 1 | 4 | — | — | 5 |
| Cystitis | D003556 | EFO_1000025 | N30 | — | 1 | 2 | — | — | 3 |
| Gonorrhea | D006069 | DOID_7551 | A54 | — | 1 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bacterial infections | D001424 | — | A49 | 7 | 2 | — | — | — | 9 |
| Bacterial skin diseases | D017192 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Respiratory tract infections | D012141 | — | J06.9 | 5 | — | — | — | — | 5 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Gepotidacin |
| INN | gepotidacin |
| Description | Gepotidacin (INN) is an experimental antibiotic that acts as a topoisomerase type II inhibitor. It is being studied for the treatment of uncomplicated urinary tract infection (acute cystitis) and infection with Neisseria gonorrhoeae (gonorrhea), including multidrug resistant strains.
|
| Classification | Small molecule |
| Drug class | antibiotics, DNA gyrase and topoisomerase IV inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=c1ccc2ncc(=O)n3c2n1C[C@H]3CN1CCC(NCc2cc3c(cn2)OCCC3)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 1075236-89-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3317856 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | DVF0PR037D (ChemIDplus, GSRS) |
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Safety
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Adverse Events
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