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Drug ReportsGentamicin
Gentamicin
Gentamicin, Pred (gentamicin) is a small molecule pharmaceutical. Gentamicin was first approved as Garamycin on 1982-01-01. It is used to treat bacterial eye infections, bacterial infections, bacterial skin diseases, central nervous system infections, and endocarditis amongst others in the USA. It is known to target transient receptor potential cation channel subfamily A member 1.
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Target
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Financial
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FDA approval date
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Study first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
musculoskeletal diseasesD009140
digestive system diseasesD004066
respiratory tract diseasesD012140
nervous system diseasesD009422
eye diseasesD005128
urogenital diseasesD000091642
cardiovascular diseasesD002318
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
Gentamicin (discontinued: Apogen, Bristagen, Garamycin, Genoptic, Gentacidin, Gentak, Gentamicin, U-gencin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Gentamicin sulfate
Tradename
Company
Number
Date
Products
GARAMYCINMerck & CoN-050039 DISCN1982-01-01
1 products, RLD
GARAMYCINMerck & CoN-050425 DISCN1982-01-01
1 products
GARAMYCINMerck & CoN-050505 DISCN1982-01-01
1 products, RLD
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Gentamicin sulfate
+
Prednisolone acetate
Tradename
Company
Number
Date
Products
PRED-GAllerganN-050586 DISCN1988-06-10
1 products, RLD
PRED-GAllerganN-050612 DISCN1989-12-01
1 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
amolg aunapproved drug other2019-03-15
celestone-gunapproved drug other2018-11-20
gentakANDA2024-06-12
gentamicinANDA2024-10-14
gentamicin sulfateANDA2025-06-12
gentamicin sulfate cream usp, 0.1%ANDA2021-05-25
gentamicin sulfate in sodium chlorideANDA2023-01-26
gentamicin sulfate opth solutionANDA2025-01-22
isotonic gentamicin sulfateANDA2009-06-25
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
respiratory tract infections—D012141J06.9
urinary tract infectionsEFO_0003103D014552N39.0
bacterial infections—D001424A49
pseudomonas infectionsEFO_0001076D011552A41.52
bacterial skin diseases—D017192—
escherichia coli infectionsEFO_1001318D004927B96.20
soft tissue infections—D018461—
bacterial eye infections—D015818—
staphylococcal infections—D013203A49.01
endocarditisEFO_0000465D004696I33
Show 35 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
D: Dermatologicals
— D06: Antibiotics and chemotherapeutics for dermatological use
— D06A: Antibiotics for topical use
— D06AX: Other antibiotics for topical use in atc
— D06AX07: Gentamicin
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01G: Aminoglycoside antibacterials
— J01GB: Other aminoglycosides in atc
— J01GB03: Gentamicin
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AA: Antibiotics, ophthalmologic
— S01AA11: Gentamicin
— S02: Otologicals
— S02A: Antiinfective drugs, otologic
— S02AA: Antiinfectives
— S02AA14: Gentamicin
— S03: Ophthalmological and otological preparations
— S03A: Antiinfectives, ophthalmologic and otologic
— S03AA: Antiinfectives
— S03AA06: Gentamicin
HCPCS
Code
Description
J1580
Injection, garamycin, gentamicin, up to 80 mg
Clinical
Clinical Trials
279 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PyodermaD011711—L08.0———1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameGentamicin
INNgentamicin
Description
Gentamicin is an antibiotic used to treat several types of bacterial infections. This may include bone infections, endocarditis, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, and sepsis among others. It is not effective for gonorrhea or chlamydia infections. It can be given intravenously, by intramuscular injection, or topically. Topical formulations may be used in burns or for infections of the outside of the eye. It is often only used for two days until bacterial cultures determine what specific antibiotics the infection is sensitive to. The dose required should be monitored by blood testing.
Classification
Small molecule
Drug classantibiotics (Micromonospora strains)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CNC(C)[C@@H]1CC[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H]2O)O1.CN[C@@H]1[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@H](C(C)N)CC[C@H]3N)[C@@H](N)C[C@H]2N)OC[C@]1(C)O.CN[C@@H]1[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H](N)C[C@H]2N)OC[C@]1(C)O
Identifiers
PDB—
CAS-ID1403-66-3
RxCUI1596450
ChEMBL IDCHEMBL3039597
ChEBI ID—
PubChem CID3467
DrugBankDB00798
UNII IDT6Z9V48IKG (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
TRPA1
TRPA1
Organism
Homo sapiens
Gene name
TRPA1
Gene synonyms
ANKTM1
NCBI Gene ID
8989
Protein name
transient receptor potential cation channel subfamily A member 1
Protein synonyms
ankyrin-like with transmembrane domains 1, Ankyrin-like with transmembrane domains protein 1, p120, Transformation-sensitive protein p120, Wasabi receptor
Uniprot ID
O75762
Mouse ortholog
Trpa1 (277328)
transient receptor potential cation channel subfamily A member 1 (Q8BLA8)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
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Estimated US medical usage
Gentamicin
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Price per prescription (USD)
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Gentamicin
+
Prednisolone
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 78,454 documents
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Safety
Black-box Warning
Black-box warning for: Gentamicin, Gentamicin sulfate in sodium chloride, Isotonic gentamicin sulfate
Adverse Events
Top Adverse Reactions
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9,203 adverse events reported
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