Gatifloxacin
Gatifloxacin, Zymaxid (gatifloxacin) is a small molecule pharmaceutical. Gatifloxacin was first approved as Zymar on 2003-03-28. It is used to treat bacterial conjunctivitis, bacterial infections, bacterial pneumonia, bronchitis, and cystitis amongst others in the USA.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Zymaxid (generic drugs available since 2013-08-28, discontinued: Zymar)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| gatifloxacin | ANDA | 2022-03-11 |
| pred-gati | unapproved drug other | 2018-02-22 |
| pred-gati-brom | unapproved drug other | 2018-02-22 |
| zymaxid | New Drug Application | 2016-09-26 |
Indications
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Agency Specific
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ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01M: Quinolone antibacterials
— J01MA: Fluoroquinolone antibacterials, systemic
— J01MA16: Gatifloxacin
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AE: Fluoroquinolone antiinfectives, ophthalmologic
— S01AE06: Gatifloxacin
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Clinical
Clinical Trials
39 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bacterial conjunctivitis | D003234 | EFO_1000829 | H10.0 | — | 1 | 4 | 1 | — | 6 |
| Conjunctivitis | D003231 | HP_0000509 | H10 | — | 1 | 4 | 1 | — | 6 |
| Cataract | D002386 | HP_0000518 | H26.9 | 1 | — | — | 2 | 2 | 5 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 1 | 1 | 1 | 1 | 1 | 4 |
| Infections | D007239 | EFO_0000544 | — | — | 1 | 2 | 1 | — | 4 |
| Communicable diseases | D003141 | — | — | — | 1 | 2 | 1 | — | 4 |
| Cataract extraction | D002387 | — | — | 1 | — | — | 1 | — | 2 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | 1 | — | 2 |
| Eye infections | D015817 | EFO_1001888 | — | — | — | 1 | 1 | — | 2 |
| Multidrug-resistant tuberculosis | D018088 | EFO_0007381 | — | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Keratitis | D007634 | HP_0000491 | H16 | — | 1 | 1 | — | — | 2 |
| Pulmonary tuberculosis | D014397 | EFO_1000049 | A15 | 1 | 1 | 1 | — | — | 2 |
| Inflammation | D007249 | MP_0001845 | — | — | — | 1 | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | — | — | 1 |
| Corneal injuries | D065306 | HP_0000559 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Retinal detachment | D012163 | EFO_0005773 | H33.2 | — | — | — | — | 2 | 2 |
| Capsule opacification | D058442 | — | H26.4 | — | — | — | — | 2 | 2 |
| Aortic dissection | D000784 | — | I71.0 | — | — | — | — | 1 | 1 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | — | — | — | 1 | 1 |
| Periapical diseases | D010483 | EFO_0010688 | — | — | — | — | — | 1 | 1 |
| Dissociative disorders | D004213 | — | F44.1 | — | — | — | — | 1 | 1 |
| Pterygium | D011625 | — | H11.0 | — | — | — | — | 1 | 1 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | — | 1 | 1 |
| Endophthalmitis | D009877 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Gatifloxacin |
| INN | gatifloxacin |
| Description | Gatifloxacin is a monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes. It has a role as an antiinfective agent, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor and an antimicrobial agent. It is a quinolinemonocarboxylic acid, a N-arylpiperazine, an organofluorine compound, a quinolone and a quinolone antibiotic. |
| Classification | Small molecule |
| Drug class | antibacterials (quinolone derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1c(N2CCNC(C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12 |
Identifiers
| PDB | — |
| CAS-ID | 112811-59-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL31 |
| ChEBI ID | 5280 |
| PubChem CID | 5379 |
| DrugBank | DB01044 |
| UNII ID | 81485Y3A9A (ChemIDplus, GSRS) |
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Estimated US medical usage
Gatifloxacin
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Additional graphs summarizing 5,490 documents
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Safety
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Adverse Events
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3,056 adverse events reported
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