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Drug ReportsGallamine
Gallamine
Flaxedil (gallamine) is a small molecule pharmaceutical. Gallamine was first approved as Flaxedil on 1982-01-01. It is known to target muscarinic acetylcholine receptor M2 and acetylcholine receptor subunit alpha.
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New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Gallamine triethiodide
Tradename
Company
Number
Date
Products
FLAXEDILDavis & GeckN-007842 DISCN1982-01-01
2 products
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ATC Codes
M: Musculo-skeletal system drugs
— M03: Muscle relaxants
— M03A: Muscle relaxants, peripherally acting agents
— M03AC: Other quaternary ammonium compounds in atc, muscle relaxants, peripherally acting
— M03AC02: Gallamine
HCPCS
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Drug
General
Drug common nameGallamine
INNgallamine triethiodide
Description
Gallamine triethiodide (Flaxedil) is a non-depolarising muscle relaxant. It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine. Gallamine is a non-depolarising type of blocker as it binds to the acetylcholine receptor but does not have the biological activity of acetyl choline. Gallamine triethiodide has a parasympatholytic effect on the cardiac vagus nerve, which causes tachycardia and occasionally hypertension. Very high doses cause histamine release.[citation needed]
Classification
Small molecule
Drug class—
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Structure (InChI/SMILES or Protein Sequence)
CC[N+](CC)(CC)CCOc1cccc(OCC[N+](CC)(CC)CC)c1OCC[N+](CC)(CC)CC
Identifiers
PDB—
CAS-ID153-76-4
RxCUI—
ChEMBL IDCHEMBL360055
ChEBI ID—
PubChem CID6172
DrugBankDB00483
UNII IDQ3254X40X2 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CHRM2
CHRM2
CHRNA1
CHRNA1
Organism
Homo sapiens
Gene name
CHRM2
Gene synonyms
NCBI Gene ID
1129
Protein name
muscarinic acetylcholine receptor M2
Protein synonyms
7TM receptor, acetylcholine receptor, muscarinic 2, muscarinic M2 receptor
Uniprot ID
Q9P1X9
Mouse ortholog
Chrm2 (243764)
muscarinic acetylcholine receptor M2 (Q9ERZ4)
Variants
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706 adverse events reported
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