Galantamine
Galantamine (galantamine) is a small molecule pharmaceutical. Galantamine was first approved as Razadyne on 2001-02-28. It is used to treat alzheimer disease in the USA. It is known to target acetylcholinesterase.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
| mental disorders | D001523 |
Trade Name
FDA
EMA
Galantamine, Zunveyl (discontinued: Galantamine, Razadyne)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Galantamine hydrobromide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| RAZADYNE | Johnson & Johnson | N-021169 DISCN | 2001-02-28 | 3 products, RLD |
| RAZADYNE | Johnson & Johnson | N-021224 DISCN | 2001-06-22 | 1 products |
| RAZADYNE ER | Johnson & Johnson | N-021615 DISCN | 2005-04-01 | 3 products, RLD |
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Benzgalantamine gluconate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ZUNVEYL | Alpha Cognition Inc. | N-218549 RX | 2024-07-26 | 3 products, RLD |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| galantamine | ANDA | 2025-10-03 |
| galantamine galantamine hydrobromide | ANDA | 2018-03-15 |
| galantamine hydrobromide | ANDA | 2025-09-12 |
| galantamine hydrobromide oral solution | ANDA | 2009-08-19 |
| razadyne | New Drug Application | 2010-11-11 |
| zunveyl | New Drug Application | 2025-02-18 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| alzheimer disease | EFO_0000249 | D000544 | F03 |
Agency Specific
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EMA
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Patent Expiration
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Clinical
Clinical Trials
115 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 3 | 3 | 21 | 15 | 13 | 55 |
| Dementia | D003704 | EFO_0003862 | F03 | — | 1 | 14 | 4 | 11 | 30 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | 4 | 5 | 3 | 2 | 12 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 5 | 3 | 3 | 1 | 11 |
| Cognition disorders | D003072 | — | — | — | 2 | 3 | 1 | 1 | 5 |
| Psychotic disorders | D011618 | — | F20.81 | — | 1 | 1 | 3 | — | 5 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | 1 | 2 | 1 | 4 |
| Mixed dementias | D000093902 | — | — | — | — | 1 | 1 | 1 | 3 |
| Depression | D003863 | — | F33.9 | — | — | 2 | 1 | — | 3 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 1 | — | 1 | 1 | 3 |
Show 16 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Brain diseases | D001927 | — | G93.40 | — | — | 2 | — | 2 | 4 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | — | 2 | — | 2 | 4 |
| Vascular dementia | D015140 | — | F01 | — | 1 | 3 | — | 1 | 4 |
| Nervous system diseases | D009422 | — | G00-G99 | — | — | 1 | — | 2 | 3 |
| Lewy body disease | D020961 | EFO_0006792 | G31.83 | — | — | 1 | — | 1 | 2 |
| Psychophysiologic disorders | D011602 | — | F45.9 | — | — | 1 | — | — | 1 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | 1 | — | — | 1 |
| Somatoform disorders | D013001 | — | F45 | — | — | 1 | — | — | 1 |
| Vascular ring | D000073872 | — | Q25.45 | — | 1 | 1 | — | — | 1 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | — | 1 | — | — | 1 |
Show 2 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tobacco use disorder | D014029 | — | F17 | — | 2 | — | — | 1 | 3 |
| Cocaine-related disorders | D019970 | — | F14 | — | 1 | — | — | 1 | 2 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | 1 | — | — | — | 1 |
| Inflammation | D007249 | MP_0001845 | — | — | 1 | — | — | — | 1 |
| Aids dementia complex | D015526 | EFO_0002608 | — | — | 1 | — | — | — | 1 |
| Traumatic brain injuries | D000070642 | — | S06 | — | 1 | — | — | — | 1 |
| Brain injuries | D001930 | — | S06.9 | — | 1 | — | — | — | 1 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | — | 1 | — | — | — | 1 |
| Traumatic stress disorders | D040921 | — | — | — | 1 | — | — | — | 1 |
| Hemorrhage | D006470 | MP_0001914 | R58 | 1 | 1 | — | — | — | 1 |
Show 5 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | 2 | — | — | — | — | 2 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Recurrence | D012008 | — | — | 1 | — | — | — | — | 1 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | 1 | — | — | — | — | 1 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | 1 | — | — | — | — | 1 |
| Oxidative stress | D018384 | EFO_1001905 | — | 1 | — | — | — | — | 1 |
| Smoking | D012907 | EFO_0004318 | — | 1 | — | — | — | — | 1 |
| Fasting | D005215 | EFO_0002756 | — | 1 | — | — | — | — | 1 |
| Postural orthostatic tachycardia syndrome | D054972 | — | G90.A | 1 | — | — | — | — | 1 |
| Tachycardia | D013610 | — | R00.0 | 1 | — | — | — | — | 1 |
Show 3 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Late onset disorders | D000067562 | — | — | — | — | — | — | 1 | 1 |
| Central nervous system diseases | D002493 | — | G96.9 | — | — | — | — | 1 | 1 |
| Neurodegenerative diseases | D019636 | EFO_0005772 | G31.9 | — | — | — | — | 1 | 1 |
| Tauopathies | D024801 | — | — | — | — | — | — | 1 | 1 |
| Caregiver burden | D000084802 | — | — | — | — | — | — | 1 | 1 |
| Addictive behavior | D016739 | EFO_0004347 | — | — | — | — | — | 1 | 1 |
| Aphasia | D001037 | — | R47.01 | — | — | — | — | 1 | 1 |
| Broca aphasia | D001039 | — | — | — | — | — | — | 1 | 1 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Galantamine |
| INN | galantamine |
| Description | Galanthamine is a benzazepine alkaloid isolated from certain species of daffodils. It has a role as an antidote to curare poisoning, an EC 3.1.1.7 (acetylcholinesterase) inhibitor, a cholinergic drug, an EC 3.1.1.8 (cholinesterase) inhibitor and a plant metabolite. It is an organic heterotetracyclic compound, a tertiary amino compound, a benzazepine alkaloid and a benzazepine alkaloid fundamental parent. It is a conjugate base of a galanthamine(1+). |
| Classification | Small molecule |
| Drug class | Acetylcholinesterase inhibitor |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc2c3c1O[C@H]1C[C@@H](O)C=C[C@@]31CCN(C)C2 |
Identifiers
| PDB | — |
| CAS-ID | 357-70-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL659 |
| ChEBI ID | 42944 |
| PubChem CID | 9651 |
| DrugBank | DB00674 |
| UNII ID | 0D3Q044KCA (ChemIDplus, GSRS) |
Target
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Galantamine
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Trends
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Safety
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Adverse Events
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5,428 adverse events reported
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