Ablavar, Ablavar (previously vasovist)(gadofosveset)
Ablavar, Vasovist (gadofosveset) is a small molecule pharmaceutical. Gadofosveset was first approved as Ablavar (previously vasovist) on 2005-10-03. It has been approved in Europe to treat magnetic resonance angiography.
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Commercial
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Drug Products
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Gadofosveset trisodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ABLAVAR | Lantheus Medical Imaging | N-021711 DISCN | 2008-12-22 | 2 products |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| vasovist | 2009-01-02 |
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Agency Specific
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HCPCS
Code | Description |
|---|---|
| A9583 | Injection, gadofosveset trisodium, 1 ml |
Clinical
Clinical Trials
22 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Peripheral arterial disease | D058729 | EFO_0004265 | — | 1 | — | 1 | 1 | — | 3 |
| Congenital heart defects | D006330 | — | Q24.9 | — | — | — | 2 | — | 2 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | — | 2 | — | 2 |
| Fibrosis | D005355 | — | — | — | — | — | 1 | 1 | 2 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | — | — | 1 | — | 1 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | — | — | — | 1 | — | 1 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | 1 | — | 1 |
| Arterial occlusive diseases | D001157 | EFO_0009085 | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Intracranial arteriosclerosis | D002537 | EFO_1000860 | I67.2 | — | — | 1 | — | — | 1 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | — | 1 | — | — | 1 |
| Peripheral vascular diseases | D016491 | EFO_0003875 | I73.9 | — | — | 1 | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | 1 | — | — | — | 2 | 3 |
| Intermittent claudication | D007383 | EFO_0003876 | I73.9 | 1 | — | — | — | 2 | 3 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronary artery disease | D003324 | — | I25.1 | — | — | — | — | 2 | 2 |
| Magnetic resonance imaging | D008279 | — | — | — | — | — | — | 2 | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 2 | 2 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | — | — | — | — | 1 | 1 |
| Hemangioma | D006391 | — | D18.0 | — | — | — | — | 1 | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | — | — | — | 1 | 1 |
| Coronary disease | D003327 | — | — | — | — | — | — | 1 | 1 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | — | — | 1 | 1 |
| Arteriosclerosis | D001161 | EFO_0009086 | I70 | — | — | — | — | 1 | 1 |
| Prostatic neoplasms | D011471 | — | C61 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Gadofosveset |
| INN | gadofosveset |
| Description | Gadofosveset (trade names Vasovist, Ablavar) is a gadolinium-based MRI contrast agent. It was used as the trisodium salt monohydrate form. It acts as a blood pool agent by binding to human serum albumin. The manufacturer (Lantheus Medical) discontinued production in 2017 due to poor sales.
|
| Classification | Small molecule |
| Drug class | phosphoro-derivatives; gadolinium derivatives (principally for diagnostic use) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 193901-90-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1908843 |
| ChEBI ID | — |
| PubChem CID | 11672461 |
| DrugBank | DB06705 |
| UNII ID | 9430ZR8ZAN (ChemIDplus, GSRS) |
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Additional graphs summarizing 783 documents
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Safety
Black-box Warning
Black-box warning for: Vasovist
Adverse Events
Top Adverse Reactions
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17 adverse events reported
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