GYKI-52466
Gyki-52466 is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target glutamate receptor 1, glutamate receptor 2, glutamate receptor 4, and glutamate receptor 3.
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Commercial
No data
Clinical
Clinical Trials
12 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | 1 | — | — | — | 3 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 1 | 3 | — | — | — | 3 |
| Dyskinesias | D020820 | HP_0002310 | G24 | 1 | 2 | — | — | — | 2 |
| Glioblastoma | D005909 | EFO_0000515 | — | — | 2 | — | — | — | 2 |
| Movement disorders | D009069 | HP_0100022 | — | 1 | 1 | — | — | — | 1 |
| Amyotrophic lateral sclerosis | D000690 | HP_0007354 | G12.21 | — | 1 | — | — | — | 1 |
| Central nervous system neoplasms | D016543 | — | — | — | 1 | — | — | — | 1 |
| Astrocytoma | D001254 | EFO_0000271 | — | — | 1 | — | — | — | 1 |
| Oligodendroglioma | D009837 | EFO_0000631 | — | — | 1 | — | — | — | 1 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | GYKI-52466 |
| INN | talampanel |
| Description | GYKI 52466 is a benzodiazepine. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1=NN=C(c2ccc(N)cc2)c2cc3c(cc2C1)OCO3 |
Identifiers
| PDB | — |
| CAS-ID | 102771-26-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL275006 |
| ChEBI ID | 79560 |
| PubChem CID | 3538 |
| DrugBank | — |
| UNII ID | CVS43XG1L5 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
GRIA1
GRIA1
GRIA2
GRIA2
GRIA4
GRIA4
GRIA3
GRIA3
Organism
Homo sapiens
Gene name
GRIA1
Gene synonyms
GLUH1, GLUR1
NCBI Gene ID
Protein name
glutamate receptor 1
Protein synonyms
AMPA 1, AMPA receptor subunit GluA1, AMPA-selective glutamate receptor 1, GluA1, gluR-1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA 1, glutamate receptor, ionotropic, AMPA 1
Uniprot ID
Mouse ortholog
Gria1 (14799)
glutamate receptor 1 (P23818)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 398 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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