Fluzoparib
Fluzoparib is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
107 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 4 | 18 | 5 | — | 2 | 28 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 4 | 10 | 4 | — | 1 | 18 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 12 | 3 | — | — | 17 |
| Triple negative breast neoplasms | D064726 | — | — | 4 | 7 | 2 | — | — | 11 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | 1 | 3 | 1 | — | — | 5 |
| Healthy volunteers/patients | — | — | — | 4 | — | 1 | — | — | 5 |
| Fallopian tube neoplasms | D005185 | — | — | — | 3 | 1 | — | — | 4 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | 1 | 1 | — | — | 3 |
| Neoadjuvant therapy | D020360 | — | — | — | 2 | 1 | — | — | 3 |
| Bone density | D015519 | EFO_0003923 | M85 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 11 | 3 | — | — | 1 | 14 |
| Prostatic neoplasms | D011471 | — | C61 | 2 | 5 | — | — | — | 7 |
| Lung neoplasms | D008175 | — | C34.90 | 2 | 3 | — | — | 1 | 5 |
| Sarcoma | D012509 | — | — | — | 5 | — | — | — | 5 |
| Small cell lung carcinoma | D055752 | — | — | 3 | 2 | — | — | 1 | 4 |
| Recurrence | D012008 | — | — | 2 | 1 | — | — | — | 3 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | 3 | — | — | — | 3 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 2 | — | — | — | 2 |
| Carcinoma | D002277 | — | C80.0 | — | 2 | — | — | — | 2 |
| Colorectal neoplasms | D015179 | — | — | — | 2 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | — | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Fluzoparib |
| INN | fuzuloparib |
| Description | Fluzoparib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. |
| Classification | Small molecule |
| Drug class | poly-ADP-ribose polymerase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2nc(C(F)(F)F)nc2C1 |
Identifiers
| PDB | — |
| CAS-ID | 1358715-18-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3930624 |
| ChEBI ID | — |
| PubChem CID | 56649297 |
| DrugBank | DB15637 |
| UNII ID | TWF0ML1CK8 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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19 adverse events reported
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