Fosmanogepix
Fosmanogepix is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mycoses | D009181 | — | B35-B49 | 5 | 1 | 2 | — | 1 | 9 |
| Candidemia | D058387 | EFO_1001282 | — | — | 2 | 1 | — | — | 3 |
| Invasive candidiasis | D058365 | EFO_1001283 | B37 | — | 1 | 1 | — | — | 2 |
| Invasive hydatidiform mole | D002820 | — | D39.2 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Invasive fungal infections | D000072742 | — | — | 1 | 1 | — | — | 1 | 3 |
| Covid-19 | D000086382 | — | U07.1 | — | 1 | — | — | — | 1 |
| Aspergillosis | D001228 | EFO_0007157 | B44 | — | 1 | — | — | — | 1 |
| Pulmonary aspergillosis | D055732 | EFO_1001834 | — | — | 1 | — | — | — | 1 |
| Candidiasis | D002177 | — | B37 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Leukemia | D007938 | — | C95 | 1 | — | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | — | 1 |
| Neutropenia | D009503 | — | D70 | 1 | — | — | — | — | 1 |
| Myeloid leukemia | D007951 | — | C92 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | — | — | — | — | 1 | 1 |
| Communicable diseases | D003141 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Fosmanogepix |
| INN | fosmanogepix |
| Description | Fosmanogepix is an experimental antifungal drug being developed by Amplyx Pharmaceuticals (now currently by Pfizer and Basilea) It is being investigated for its potential to treat various fungal infections including aspergillosis, candidaemia, and coccidioidomycosis.
|
| Classification | Small molecule |
| Drug class | phosphoro-derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1c(-c2cc(Cc3ccc(COc4ccccn4)cc3)no2)ccc[n+]1COP(=O)([O-])O |
Identifiers
| PDB | — |
| CAS-ID | 1169701-00-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297591 |
| ChEBI ID | — |
| PubChem CID | 44123754 |
| DrugBank | DB15183 |
| UNII ID | 1XQ871489P (ChemIDplus, GSRS) |
Target
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Variants
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Trends
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Safety
Black-box Warning
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Adverse Events
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10 adverse events reported
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